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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia
Stefanus Lembar
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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KELUARGA DISULFIT PROTEIN ISOMERASE ANGGOTA 4(PDIA4) DI KANKER PAYUDARA DENGAN METASTASIS Stefanus Lembar; Sheella R. Bororing; Lilis Lilis
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 20, No 1 (2013)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v20i1.442

Abstract

Protein disulfide isomerase (PDI) is a member of thioredoxin superfamily that is secreted in the lumen of the endoplasmic reticulum (ER) in mammalian cells. PDI catalyzes disulfide bond formation, reduction, or isomerization of newly synthesized proteins in the lumen of the RE. PDIA4 is a member of the PDI family, which is also expressed in the mammary gland. Low expression of PDIA4 probably as a result of the stress of RE in hypoxic conditions. These conditions will enhance the ability of tumor cells in mammary tissue to divide aggressively and metastasize. A total of 61 breast cancer patients aged 23−90 years (60 women and 1 man) in Jakarta, Indonesia have participated in this study after signing the informed consent letter. The diagnosis of metastasis is confirmed by the examination of bone scanning. Measurement of PDIA4 concentration is performed by the quantitative enzyme-linked immunosorbent assay (ELISA) using a commercial kits. Based on the examination of the bone scanning, there were 23 (62.5%) subjects with metastatic and 38 (37.5%) subjects non-metastatic. The mean of age of the subjects with metastatic were significantly higher than non-metastatic subjects (p=0.028), which is 51.4 (45.9–56.8) and 44.2 (40.4–48.0). The median of PDIA4 concentrations in serum of subjects with metastatic, i.e. 7.7 (1.0–37.2) ng/ml was significantly lower than non-metastatic subjects (p=0.044), i.e. 9.4 (2.2–69. 6) ng/mL. The concentration of PDIA4 in serum of breast cancer patients with metastatic were significantly lower than non-metastatic patients. It shows that the concentration of PDIA4 have decreased in incidence of metastatic breast cancer.
ADRENOMEDULIN DI KARSINOMA PAYUDARA DENGAN METASTASIS Stefanus Lembar
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 21, No 2 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v21i2.1106

Abstract

Metastasis is the leading cause of mortality in patients with breast cancer. The molecular biology behind the metastasis is verycomplex and may require changes in the regulation of the cell cycle, protein that promotes autocrine growth loop, and the protein thatcauses epithelial to mesenchymal transition. More complex, it is clear that the biology of metastasis is partly governed by the non-tumourcells, including fibroblasts, endothelial cells and myoepithelial cells. Adrenomedullin is an autocrine growth factor produced by the renalcarcinoma cells. However, previous studies indicated that adrenomedullin can be secreted in various carcinoma tissue and carcinoma cells.Adrenomedullin may mediate immunosuppression, antiapoptosis, angiogenesis and proliferation, thus it is an important tumour cellsurvival factor underlying human carcinoma genesis. The role of adrenomedullin in the carcinoma genesis, invasion and metastasis hasbeen greatly focused. The aim of this study was to determine the concentration of adrenomedullin in patients with metastatic breast cancer.A total of 64 patients with breast cancer aged 21–90 years (63 women and 1 man) in Jakarta has been participated in this study aftersigning informed consent. Metastasis was confirmed by examination of bone scanning. Concentrations of adrenomedullin were measuredby EnzymeLinked Immunosorbent Assay (ELISA) using a commercial kit. Based on examination of bone scanning, there were 24 (37.5%)subjects with metastasis and 40 (62.5%) nonmetastasis. Mean of the concentrations of adrenomedullin in the subjects with metastasiswas 252.5 (205.0–299.9) pg/mL, while in the nonmetastasis was 203.1 (178.7–227.5) pg/mL. The concentrations of adrenomedullinwere significantly higher in subjects with metastasis than nonmetastasis (p=0.041). High concentration of adrenomedullin in the subjectswith metastasis suggests that adrenomedullin may be more likely to be involved in metastasis.
DISFUNGSI TIROID, ANTIBODI PEROKSIDASE DAN HORMON PERANGSANGNYA Stefanus Lembar; Benny Hartono
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 15, No 2 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v15i2.948

Abstract

Hypothyroid in the pregnancy particularly in first trimester can influence the development of brain and neurophysiologic system infoetus. The diagnose approach of hypothyroid with laboratory evaluation which measure AntiTPO, TSH, and FT4 is the recommendedchoice. Full attention should be paid towards the treatment and management of hypothyroid in the pregnancy in order to avoid anybad complication.
Penurunan Rasio Neutrofil terhadap Limfosit pada Pasien Tuberkulosis Sesudah Terapi Intensif Caroline Ciptasari; Mario Steffanus; Stefanus Lembar
JIMKI: Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Vol 6 No 1 (2018): JIMKI : Jurnal Ilmiah Mahasiswa Kedokteran Indonesia Volume 6.1 Edisi April - Sep
Publisher : BAPIN-ISMKI (Badan Analisis Pengembangan Ilmiah Nasional - Ikatan Senat Mahasiswa Kedokteran Indonesia)

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Tuberculosis is a health problem with a high incidence rate in Indonesia. This disease caused by bacterial infection of Mycobacterium tuberculosis, Bacterial infection will activate the body's immune response that will induce inflammatory process. Inflammation caused by bacterial infection is characterized by an increase in the number of neutrophils (neutrophilia) and a decrease in the number of lymphocytes (lymphocytopenia). Therapy is done to reduce the incidence of TB. TB therapy is divided into 2 phases, an intensive and continuous phase. This therapy was use to killing bacteria and suppressing the inflammatory response that occurs as a result of the bacterial infection. Objective: The purpose of this study was to determine the improvement of the body's immune response through the neutrophil to lymphocytes ratio (NLR) before and after intensive therapy in patients with tuberculosis. Method: The study was conducted at Atma Jaya Hospital, taking data was held from January 2017 to May 2017 with a total of 44 patients as samples. Data were collected secondary through medical record. The results were obtained using the wilcoxcon test.Result: The results of this study was NLR decrease after therapy and this result are parallel with the decrease in the number of neutrophils and the increase in the number of lymphocytes after intensive therapy. Conclusion: There is an improvement in the condition of the patient after undergoing intensive TB therapy
Co-Authors Benny Hartono Caroline Ciptasari Lilis Lilis Mario Steffanus Sheella R. Bororing