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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML) Journal of Medicine and Health
Christine Sugiarto
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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LEUKOSITOSIS BER-FLAGGING BINTANG () BERPOTENSI ADANYA INTERFERENSI ALAT ANALISIS HEMATOLOGI OTOMATIS Christine Sugiarto; Leni Lismayanti; Nadjwa Zamalek Dalimoenthe
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 2 (2011)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i2.1026

Abstract

Leukocytosis is a condition in which there is an increasing number of white blood cell count in the peripheral blood compared to thenormal range based on age. Several conditions can amplify leukocyte count from haematological auto analyzers, not only those whichcorrespond to the pathologic and physiologic condition, but also with other factors, such as diluent and haematological auto analyzer’smethods. The information about these factors should be evaluated to lessen errors in the patient’s diagnosis and therapy. This casereport describes a leukocytosis in a 35-day old baby boy, diagnosed as duodenal obstruction, admitted in Paediatric Surgery Department,Hasan Sadikin Hospital, Bandung. Discrepancies occurred in this patient’s leukocyte count with some different haematological autoanalyzers. The leukocyte count from the auto analyzer by impedance method and ammonium salt diluent was 129.200/mm3 which wasindicated by a star-flagged (), while from the auto analyzer with light scatter method and anhydrous sodium sulphate and sodiumchloride diluent was 9.200/mm3, from manual count by the counting chamber with Turk diluent was 14.200/mm3 and the estimationby peripheral blood smear was 7.000–10.000/mm3. False leukocytosis by auto analyzer with impedance method was caused by thelimitation of the analyzer’s method and by the erythrocyte lysine reagent (diluent) using ammonium salt. As investigated in this case,the interferences were thought as being caused by the Lyses-resistant Red Blood Cells, thus the non-lysed/lyses cells which were enlargedin size were identified as leukocytes other than erythrocytes. It can be that the white blood concluded cell count examination which isindicated by star-flagged (), or white blood cell count >100.000/mm3 must be confirmed by manual examination (counting chamberand peripheral blood smear) or by another haematological auto analyzer method that has a different and more potent diluent
Correlation of Total Lymphocyte Count with CD4 Count in HIV/AIDS Patients Ardo Sanjaya; Christine Sugiarto; Ronald Jonathan
Journal of Medicine and Health Vol 1 No 1 (2015)
Publisher : Universitas Kristen Maranatha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.28932/jmh.v1i1.500

Abstract

HIV infection is a chronic infection of the immune system with a target of CD4 cells. Total lymphocyte count (TLC) can be done in resource-limited areas and are able to be used as a substitute to CD4 count. An increase in CD8 count can disturb the correlation between CD4 and TLC especially during the late clinical stage.Objective of this research is to find out the correlation of total lymphocyte count with CD4 count and to find out the influence of the clinical staging on the correlation of total lymphocyte count and CD4 count.This study is an observational, analytical and cross sectional study using the medical records of Klinik Teratai RSHS Bandung. The data is sorted according to the WHO clinical staging and are analyzed using Pearson’s correlation and Fisher’s transformation with α=0.05. The results showed that TLC have a correlation with CD4 count in all stadiums (r: 0,501-0,684, p<0,01). There is no significant difference of the correlation coefficients between the clinical stages (p>0.05). There is a correlation between TLC and CD4 count on HIV infected patients and there is no significant decrease of correlation of TLC and CD4 count on HIV infected patients with worsening of the WHO clinical stages. Keywords: CD4 count, total lymphocyte count, HIV/AIDS
Co-Authors Ardo Sanjaya Leni Lismayanti Nadjwa Zamalek Dalimoenthe Ronald Jonathan