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Efek Pemberian Ekstrak Buah Salak (Salacca zalacca) dalam menurunkan kadar glukosa darah pada tikus model Diabetes melitus Olvie Syenni Datu; Julianri Sari Lebang; Elly Juliana Suoth
Jurnal MIPA Vol. 12 No. 1 (2023)
Publisher : Universitas Sam Ratulangi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/jm.v12i1.44267

Diabetes Mellitus is a chronic disease characterized by elevated blood glucose levels. Diabetes Mellitus is a global disease that affects 536.6 million people in the world and is predicted to increase to 643 million people in 2030 and 783.2 million people in 2045. Snake fruit is one of the fruits in North Sulawesi that has the potential to be developed. be an alternative to treatment. The aims of this study is was to examine the effect of snake fruit extract in rats with diabetes mellitus model. The study used 5 groups, negative control group was given NaCMC solution, the positive control group was given metformin and the treatment group was given snake fruit extract with concentrations of 10%, 20% and 40%. The parameters observed in this study were body weight and blood glucose profile. The study showed that the administration of snake fruit extract had a significant effect on blood glucose profiles and body weight with p < 0.05 and there were significant differences between each treatment group both in the glucose profile parameters and body weight of rats.

UJI EFEKTIVITAS GEL EKSTRAK BUAH TOMAT (Solanum lycopresicum L) TERHADAP LUKA SAYAT PADA TIKUS PUTIH JANTAN (Rattus novergicus) Stevani Febriyanti Supit; Widdhi Bodhi; Julianri Sari Lebang
PHARMACON Vol. 10 No. 4 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.37401

ABSTRACTTomato (Solanum lycopresicum L) are known to contain compounds such as solanine (0.007%), saponins, folic acid, bioflavonoids, protein, fat, and vitamins. The purpose of this study is to make a tomato fruit extract gel and to determine its effectiveness as wound healer in white rats. Gel was made using various concentrations of tomato extract 8%, 12% and 16%. Incision wounds on rats were treated with Bioplacenton (positive control), base gel preparations (negative control), and tomato gel with a concentration of 8%, 12% and 16%. The results showed a concentration of 16% had a healing time of 7 days with an average wound length of 0.06 cm. The statistical test using ANOVA One Way showed that there was a significant difference in the duration of wound healing between 5 treatment groups and the most effective was a concentration of 16% with a healing time of 7 days compared to negative controls and a concentration of 8%, 12%. It can be concluded that the gel preparation containing 16% of tomato fruit extract has good effectiveness in healing incisions.Â Keywords: Tomato Fruit (Solanum lycopresicum L), Wound Healing, Gel Â ABSTRAKBuah Tomat (Solanum lycopresicum L) diketahui memiliki kandungan senyawa seperti solanin (0,007%), saponin, asam folat, bioflavonoid,protein, lemak, dan vitamin. Tujuan penelitian untuk membuat sediaan gel ekstrak buah tomat serta mengetahui efektivitas penyembuhan luka sayat pada tikus putih. Ekstrak tomat dibuat menjadi sediaan gel dengan variasi konsentrasi ekstrak 8%, 12% dan 16%. Luka sayat pada tikus diolesi dengan Bioplacenton (kontrol positif), basis sediaan gel (kontrol negatif), dan gel ekstrak buah tomat konsentrasi 8%, 12% dan 16%. Hasil penelitian menunjukkan konsentrasi 16 % memiliki waktu penyembuhan 7 hari dengan panjang luka rerata 0,06 cm. Uji statistik menggunakan ANOVA One Way menunjukkan adanya perbedaan signifikan lamanya penyembuhan luka sayat diantara 5 kelompok perlakuan yang paling efektif konsentrasi 16% dengan waktu penyembuhan selama 7 hari dibandingkan kontrol negatif dan konsentrasi 8%, 12%. Dapat disimpulkan sediaan gel yang mengandung ekstrak buah tomat sebanyak 16% memiliki efektivitas baik terhadap penyembuhan luka sayat.Â Kata kunci : Buah Tomat (Solanum lycopresicum L), Penyembuhan Luka Sayat, Gel

UJI EFEKTIVITAS ANTIHIPERKOLESTEROLEMIA EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lam) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) Desy Intania Nurdin; Widdhi Bodhi; Julianri Sari Lebang
PHARMACON Vol. 10 No. 4 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.37417

ABSTRACTMoringa leaves (Moringa oleifera Lam) contain flavonoids, antioxidants, and alkaloids that can lower cholesterol levels, blood pressure and blood sugar levels. This study aims to determine the effectiveness of kelorterol leaf extract against male white rats (Rattus norvegicus). Test animals were induced by propylthiouracil and high fat diet for 14 days. Followed by administration of Na-CMC, Simvastatin, and Moringa leaf extract 3.6mg/200gBB, 7.2mg/200gBB, and 10.8mg/200gBB for 14 days. Cholesterol measurements were carried out on days 0, 14, and 28. The results showed that Moringa leaf extract at a dose of 10.8mg/200gBBÂ had cholesterol lowering activity greater than other doses with an average percentage of 27.58%. The results of statistical analysis using the ANOVA method (Î± = <0.05) showed that there was a significant difference between the negative control and the other treatment groups. Can be concluded that the most effective dose of extract to lower cholesterol was at a dose of 10.8 mg/200gBB.Â Keywords: Moringa leaves, antihypercholesterolemia, Propylthiouracil Â ABSTRAKDaun kelor (Moringa oleifera Lam) memiliki kandungan flavonoid, antioksidan, dan alkaloid yang dapat menurunkan kadar kolesterol, tekanan darah dan kadar gula darah. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak daun kelorterol terhadap tikus putih jantan (Rattus norvegicus). Hewan uji diinduksi propiltiourasil dan pakan tinggi lemak selama 14 hari. Dilanjutkan dengan pemberian Na-CMC, Simvastatin, dan ekstrak daun kelor 3,6mg/200gBB, 7,2mg/200gBB, dan 10,8mg/200gBB selama 14 hari. Pengukuran kolesterol dilakukan pada hari ke 0, 14, dan 28. Hasil penelitian yang diperoleh menunjukan bahwa ekstrak daun kelor dengan dosis 10,8mg/200gBB memiliki aktivitas penurunan kolesterol lebih besar dari dosis lain dengan rata-rata presentase 27,58%. Hasil analisa statistik dengan metode ANOVA (Î± = <0,05) menunjukkan terdapat perbedaan signifikan antara kontrol negatif dengan kelompok pemberian lainnya. Dapat disimpulkan bahwa dosis ekstrak yang paling efektif menurunkan kolesterol yaitu pada dosis 10,8 mg/200gBB.Â Kata kunci: Daun kelor, antihiperkolesterolemia, Propiltiourasil

KARAKTERISASI EKSTRAK ETANOL KULIT BUAH LEMON SUANGGI (Citrus limon L.) Anita Rahel Meilina Paendong; Fatimawali Fatimawali; Julianri Sari Lebang
PHARMACON Vol. 11 No. 1 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.11.2022.39141

ABSTRACTThe suanggi lemon peel has been widely used by the public for traditional medicine. Traditional medicinal raw materials need to be characterized in order to improve product status and ensure the pharmacological effects of herbs. This study aims to determine the characterization of the ethanol extract of the suanggi lemon peel. In this study, the extraction was carried out by the maceration method. The viscous extract obtained from the maceration of the suanggi lemon peel used 95% ethanol with a yield of 9.54%. Results of Specific parameters are the name of the plant is lemon suanggi (Citrus limon L), organoleptic testing show extract has thick consistency, dark green in color, distinctive smell of lemon suanggi, levels of water soluble compounds and ethanol (95% and 94%), respectively. Extract contain alkaloid, tannins, flavonoids, and saponins compounds. The results of non-specific parameters showed the value of drying shrinkage of 9.83%, moisture content 23.93%, specific density of 0.829 g/mL, ash content of 1.9%. From the results obtained, it can be concluded that except for the water content of the ethanol extract of suanggi lemon peel (Citrus limon L) fulfill the requirement based on the (Depkes RI) 2000.Keywords: Lemon suanggi (Citrus limon L), Maceration, CharacterizationABSTRAKKulit buah lemon suanggi telah banyak digunakan oleh masyarakat untuk pengobatan tradisional. Bahan baku obat tradisional perlu untuk dikarakterisasi agar meningkatkan status produk serta menjamin efek farmakologi herbal. Penelitian ini bertujuan untuk menentukan karakterisasi ekstrak etanol kulit buah lemon suanggi. Pada penelitian ini penyarian dilakukan dengan metode maserasi. Ekstrak kental yang diperoleh dari hasil maserasi kulit buah lemon suanggi menggunakan etanol 95% dengan perolehan rendemen 9,54%. Hasil Parameter spesifik menunjukan nama tanaman adalah buah lemon suanggi (Citrus limon L) pengujian organoleptik yaitu berkonsistensi kental, berwarna hijau pekat, berbau khas lemon suanggi, kadar senyawa larut air dan etanol masingmasing 95% dan 94%, dengan kandungan senyawa alkaloid, tanin, flavonoid, saponin. Hasil parameter non spesifik menunjukan nilai susut pengeringan 9,83%, kadar air 23,93%, bobot jenis 0,829 g/mL , kadar abu 1,9%. Dari hasil yang diperoleh dapat disimpulkan bahwa ekstrak etanol kulit buah lemon suanggi (Citrus limon L) memenuhi parameter spesifik dan parameter non spesifik berdasarkan Depkes RI 2000 kecuali kadar air.Kata kunci: Lemon Suanggi (Citrus Limon L), Maserasi, Karakterisasi

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