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All Journal PHARMACON Jurnal Ilmu Kefarmasian Indonesia
Widdhi Bodhi
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Variasi Basis Salep Minyak Kemiri (Aleurites moluccana) dan Uji Daya Penyembuhannya Pada Luka Kelinci Paulina Veronika Yamlean; Edwin De Queljoe; Widdhi Bodhi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 2 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (416.905 KB) | DOI: 10.35814/jifi.v17i2.647

Abstract

Candlenut plant in Indonesia is still limited to traditional uses such as cooking spices and traditional medicines. Only a few research has been done on Candlenut oil. The purpose of this study is to make ointment base variations toward the quality of Candlenutoil ointment with 12.5% concentration andits healing potential teston open wounds in rabbits infected with the Staphylococcus aureus bacteria. This research method is a laboratory experiment using 3 variations of base ointment namely hydrocarbon base, absorption base and water soluble base with Candlenut oil test solution of 12.5%. The results showed the quality test of the ointment with three variations of ointment base fulfilled the requirements of organoleptic test, homogeneity test, and pH test, but Candlenutoil ointment of 12.5% with hydrocarbon base did not meet the scattering power requirement. The results of the ANOVA test showed no significant difference between the base variations of the ointment and the size of wound healing. This shows that the three variations of the 12.5% Candlenut oil ointment base can be used in healing open wounds on rabbits (Oryctolagus cuniculus) infected with the Staphylococcus aureus bacteria.
Antibacterial Activity Test of African Leaf Extract (Vernonia amygdalina) Against Staphylococcus aureus and Pseudomonas aeruginosa Bacteria Growth. Trifosa Sarijowan; Widdhi Bodhi; Julianri Lebang
PHARMACON Vol. 11 No. 4 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Abstract

African leaves (Vernonia amygdalina) are known to be one part of the plant that has antibacterial activity that has the potential to be developed as a traditional medicine. This study aims to determine antibacterial activity, the effect of increasing extracts and the most effective concentration on the inhibitory power of the growth of Staphylococcus aureus and Pseudomonas aeruginosa bacteria. The antibacterial activity of african leaf ethanol extract with concentrations of 5%, 10%, 20%, 40%, 80% was tested using the disc diffusion method by observing the diameter of the inhibitory zone compared to Ciprofloxacin as a positive control and CMC as a negative control. The results of measurements of the diameter of the inhibition zone concentrations of 5% (7.0 mm), 10% (9.2 mm), 20% (11.5 mm), 40% (13.8 mm), 80% (15.7 mm) in S. aureus bacteria, 5% (8.1 mm), 10% (9.1 mm), 20% (11.6 mm), 40% (13.1 mm), 80% (15.1 mm) in P. aeruginosa bacteria have provided activity to inhibit the growth of test bacteria. The results were analyzed using One Way ANOVA and continued with the Duncan test. Research shows that the higher the concentration of the extract, the greater the diameter of the inhibitory zone of bacterial growth. An extract concentration of 80% is the most effective concentration for inhibiting S. aureus and P. aeruginosa bacteria.
ANTIDIABETIC ACTIVITY TEST OF BITTER GOURD EXTRACT (Momordica charantia) AS AN INHIBITOR OF α - GLUCOSIDASE ENZYME BY IN SILICO Kezya Wowor; Widdhi Bodhi; Olvie Datu; Axl Windah
PHARMACON Vol. 11 No. 4 (2022): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

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Abstract

ABSTRACTDiabetes mellitus (DM) is a metabolic disorder that interferes with the metabolism of carbohydrates, fats, and proteins. This study aims to determine the types of bioactive compounds contained in bitter melon extract and to analyze interaction of targeted compounds against the α -glucosidase enzyme using the in silico approach. The results of the analysis using Gas Chromatography- Mass Spectrometer (GCMS) used to obtain information on bioactive compounds that will be used as ligands to be attached to the α-glucosidase enzyme. Furthermore, the potential ability of each compound as antidiabetic was test using PyRx application and Acarbose was its control. The results of the GCMS analysis of this study contained 23 compounds detected in the methanol extract of bitter melon. This research proves that the compound Spirost-8-en-11 one, 3 hydroxy, (3ß,5a,14ß, 20ß, 22ß, 25R) with a binding affinity of -9.0 kcal/mol and Cholesta-8,24-dien -3-ol, 4-methyl-, (3ß,4a)- with a binding affinity of -8.3 kcal/mol have a good conformation. This research can be concluded that the two compounds can be developed as antidiabetic.  Keywords: Bitter Melon (Momordica charantia), antidiabetic, α - Glucosidase enzyme, molecular docking
UJI EFEKTIVITAS GEL EKSTRAK BUAH TOMAT (Solanum lycopresicum L) TERHADAP LUKA SAYAT PADA TIKUS PUTIH JANTAN (Rattus novergicus) Stevani Febriyanti Supit; Widdhi Bodhi; Julianri Sari Lebang
PHARMACON Vol. 10 No. 4 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.37401

Abstract

ABSTRACTTomato (Solanum lycopresicum L) are known to contain compounds such as solanine (0.007%), saponins, folic acid, bioflavonoids, protein, fat, and vitamins. The purpose of this study is to make a tomato fruit extract gel and to determine its effectiveness as wound healer in white rats. Gel was made using various concentrations of tomato extract 8%, 12% and 16%. Incision wounds on rats were treated with Bioplacenton (positive control), base gel preparations (negative control), and tomato gel with a concentration of 8%, 12% and 16%. The results showed a concentration of 16% had a healing time of 7 days with an average wound length of 0.06 cm. The statistical test using ANOVA One Way showed that there was a significant difference in the duration of wound healing between 5 treatment groups and the most effective was a concentration of 16% with a healing time of 7 days compared to negative controls and a concentration of 8%, 12%. It can be concluded that the gel preparation containing 16% of tomato fruit extract has good effectiveness in healing incisions. Keywords: Tomato Fruit (Solanum lycopresicum L), Wound Healing, Gel  ABSTRAKBuah Tomat (Solanum lycopresicum L) diketahui memiliki kandungan senyawa seperti solanin (0,007%), saponin, asam folat, bioflavonoid,protein, lemak, dan vitamin. Tujuan penelitian untuk membuat sediaan gel ekstrak buah tomat serta mengetahui efektivitas penyembuhan luka sayat pada tikus putih. Ekstrak tomat dibuat menjadi sediaan gel dengan variasi konsentrasi ekstrak 8%, 12% dan 16%. Luka sayat pada tikus diolesi dengan Bioplacenton (kontrol positif), basis sediaan gel (kontrol negatif), dan gel ekstrak buah tomat konsentrasi 8%, 12% dan 16%. Hasil penelitian menunjukkan konsentrasi 16 % memiliki waktu penyembuhan 7 hari dengan panjang luka rerata 0,06 cm. Uji statistik menggunakan ANOVA One Way menunjukkan adanya perbedaan signifikan lamanya penyembuhan luka sayat diantara 5 kelompok perlakuan yang paling efektif konsentrasi 16% dengan waktu penyembuhan selama 7 hari dibandingkan kontrol negatif dan konsentrasi 8%, 12%. Dapat disimpulkan sediaan gel yang mengandung ekstrak buah tomat sebanyak 16% memiliki efektivitas baik terhadap penyembuhan luka sayat. Kata kunci : Buah Tomat (Solanum lycopresicum L), Penyembuhan Luka Sayat, Gel
UJI EFEKTIVITAS ANTIHIPERKOLESTEROLEMIA EKSTRAK ETANOL DAUN KELOR (Moringa oleifera Lam) PADA TIKUS PUTIH JANTAN (Rattus norvegicus) Desy Intania Nurdin; Widdhi Bodhi; Julianri Sari Lebang
PHARMACON Vol. 10 No. 4 (2021): PHARMACON
Publisher : UNIVERSITAS SAM RATULANGI

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35799/pha.10.2021.37417

Abstract

ABSTRACTMoringa leaves (Moringa oleifera Lam) contain flavonoids, antioxidants, and alkaloids that can lower cholesterol levels, blood pressure and blood sugar levels. This study aims to determine the effectiveness of kelorterol leaf extract against male white rats (Rattus norvegicus). Test animals were induced by propylthiouracil and high fat diet for 14 days. Followed by administration of Na-CMC, Simvastatin, and Moringa leaf extract 3.6mg/200gBB, 7.2mg/200gBB, and 10.8mg/200gBB for 14 days. Cholesterol measurements were carried out on days 0, 14, and 28. The results showed that Moringa leaf extract at a dose of 10.8mg/200gBB  had cholesterol lowering activity greater than other doses with an average percentage of 27.58%. The results of statistical analysis using the ANOVA method (α = <0.05) showed that there was a significant difference between the negative control and the other treatment groups. Can be concluded that the most effective dose of extract to lower cholesterol was at a dose of 10.8 mg/200gBB. Keywords: Moringa leaves, antihypercholesterolemia, Propylthiouracil  ABSTRAKDaun kelor (Moringa oleifera Lam) memiliki kandungan flavonoid, antioksidan, dan alkaloid yang dapat menurunkan kadar kolesterol, tekanan darah dan kadar gula darah. Penelitian ini bertujuan untuk mengetahui efektivitas ekstrak daun kelorterol terhadap tikus putih jantan (Rattus norvegicus). Hewan uji diinduksi propiltiourasil dan pakan tinggi lemak selama 14 hari. Dilanjutkan dengan pemberian Na-CMC, Simvastatin, dan ekstrak daun kelor 3,6mg/200gBB, 7,2mg/200gBB, dan 10,8mg/200gBB selama 14 hari. Pengukuran kolesterol dilakukan pada hari ke 0, 14, dan 28. Hasil penelitian yang diperoleh menunjukan bahwa ekstrak daun kelor dengan dosis 10,8mg/200gBB memiliki aktivitas penurunan kolesterol lebih besar dari dosis lain dengan rata-rata presentase 27,58%. Hasil analisa statistik dengan metode ANOVA (α = <0,05) menunjukkan terdapat perbedaan signifikan antara kontrol negatif dengan kelompok pemberian lainnya. Dapat disimpulkan bahwa dosis ekstrak yang paling efektif menurunkan kolesterol yaitu pada dosis 10,8 mg/200gBB. Kata kunci: Daun kelor, antihiperkolesterolemia, Propiltiourasil
Co-Authors Axl Windah Desy Intania Nurdin Edwin De Queljoe Julianri Lebang Julianri Sari Lebang Kezya Wowor Olvie Datu Paulina yamlean Stevani Febriyanti Supit Trifosa Sarijowan