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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Berkala Penelitian Hayati Hang Tuah Medical Journal
NUGROHO EKO WIRAWAN BUDIANTO
Bagian Farmakologi Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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ETHANOL EXTRACT TURMERIC (Curcuma domestica val) IN PREVENTING AN INCREASED GASTIC ACIDITY ON Rattus norvegicus WHICH INDUCED BY HISTAMINE Budianto, Nugroho Eko Wirawan
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 3, No 1 (2014): Edisi Maret 2014
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Gastric ulcer is one of the increase gastric acid causes which mediated by H2 reseptor. Tumeric is extracted using the ethanol 96% and it is tested using Rattus norvegicus Wistar strain to know the effect as anti gastritis. There’s a suspicion whether an ethanol extraction from tumeric which has anti H2 receptor effect can be use to prevent gastric ulcer causes from histamine release. Based on that, we want to study whether tumeric can be use to prevent the increase of histamine induce gastric acid and can also be use as gastric protective by looking at microscopic  image of gastric, gastric pH from Rattus norvegicus Wistar strain.Methods: Male Wistar rats were divided Into five groups: 1) Na CMC control group, 2) CMC Na io histamine plus 300 mg / kg ip groups, 3) ethanol turmeric extract 1000 mg / kg io histamine plus 300 mg / kg ip treated groups, 4) ethanol turmeric extract 2000 mg / kg io histamine plus 300 mg / kg ip treated groups. Rats were sacrified at 6 h after injection of histamine, and stomach tissues were harvested for free acid, total acid, organic acid, pH.Results: Giving P2 ethanol extract of tumeric intra oral decrease free acid level, total acid, organic acid and pH gastric acid which is induced by giving an intra peritoneal histamin. Ethanol extract of tumeric decrease incidence and preventable for ulcus gastric causes by histamin.Conclusion: an ethanol extract of tumeric decrease the levels of free acid, total acid, organic acid and pH gastric. Ethanol tumeric extract 2000 mg/kg is a recommended dosage 
Difference of Effectiveness Acarbose with Ethanol Extract Purple Eggplant’s Peel (Solanum melongena L) to Reduce Blood Sugar Levels in White Rat (Rattus norvegicus) Induced by Sucrose Budianto, Nugroho Eko Wirawan; Hairullah, Hairullah
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 6, No 2 (2017): EDISI SEPTEMBER 2017
Publisher : Universitas Wijaya Kusuma Surabaya

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Abstract

Acarbose is an oligosaccharide human made who is a competitive inhibitor acarbose and can inhibit the action of the enzyme α-glucosidase, causing a slowdown in the digestion of carbohydrate compounds. Purple eggplant skin is included in the flavonoid compound. Purple eggplant  skin as well as an antioxidant that can control blood glucose levels and prevent complications of diabetes. Purple eggplant skin contains flavonoid kaempferol and has the effect of inhibiting the enzyme alpha-glucosidase. Based on these researchers want to know the difference in effectiveness between the ethanol extract of purple eggplant skin  and acarbose to decrease blood sugar levels of mice. The study population using white rats with a total sample size of 30 rats. Research data analysis using One Way Anova Test. Methods: Male rats strain Wistar were divided into 5 groups. 1) Control (CMC Na 1 ml io), 2) Group 1  (The ethanol extract of 50 mg / kg in the CMC Na io),  3) Group 2  (The ethanol extract 100 mg / kg in CMC Na io), 4) Group 3  (the ethanol extract 200 mg / kg in the CMC Na io), 5) Group 4 (Acarbose 4.5 mg / kg in distillated water io). The result showed ethanol extract of purple eggplant skin in group 2 showed the best effectiveness in lowering blood sugar levels of white rats by oral sucrose injection. And there is no significant difference between the effectiveness of the ethanol extract of purple eggplant skin and acarbose in lowering blood sugar levels of white rats by oral sucrose injection.
EKSTRAK DAUN AVICENNIA ALBA DALAM MENCEGAH PENINGKATAN KEASAMAN LAMBUNG MUS MUSCULUS YANG DIINDUKSI ASPIRIN Budianto, Nugroho Eko Wirawan
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 8, No 1 (2019): EDISI MARET 2019 (available online since April 2019)
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (778.396 KB) | DOI: 10.30742/jikw.v8i1.525

Abstract

Daun mangrove diekstrak dengan menggunakan etanol 96% dan dipakai sebagai pencegahan peningkatan asam lambung dengan uji hewan coba Mus musculus. Tujuan penelitian untuk mengetahui potensi ekstrak daun Avicennia alba sebagai pencegahan peningkatan asam lambung karena induksi aspirin, dengan melihat kadar asam bebas, asam total, asam organik dan pH lambung Mus musculus. Metode penelitian Mus musculus dibagi dalam 5 kelompok 1). Kelompok kontrol negatif, 2). Kelompok kontrol positif, 3). 3 Kelompok perlakuan dengan dosis berbeda yaitu ekstrak daun Avicennia alba 1,3 mg/20 g BB, ekstrak daun Avicennia alba 2,6 mg/20 g BB, ekstrak daun Avicennia alba 5,2 mg/20 g BB. Hasil menunjukan bahwa Pemberian ekstrak etanol Avicennia alba P2 yang diberikan secara intra oral mencegah peningkatan kadar asam bebas, asam total, asam organik dan pH asam lambung yang diinduksi oleh aspirin yang diberikan secara intra oral. Kesimpulan penelitian adalah ekstrak etanol Avicennia alba mencegah peningkatan kadar asam bebas, asam total, asam organik dan pH lambung. Ekstrak etanol Avicennia alba 2,6 mg/ 20 g BB merupakan dosis yang dianjurkan
Potential improvement in the safety and quality of traditional fermented soybean products: A narrative review Budhi Setiawan; Nugroho Eko Wirawan Budianto; Masfufatun Masfufatun
JURNAL PENELITIAN BIOLOGI BERKALA PENELITIAN HAYATI Vol 28 No 1 (2022): December 2022
Publisher : The East Java Biological Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23869/bphjbr.28.1.20222

Abstract

Soybeans are one of the most significant crops in the world due to their nutritionally valuable. It has been converted to produce a variety of fermented soybean products. During conventional soybean fermentation, microorganisms are involved, biochemical reactions occur, and bioactive components are produced. With the rise of people's living standards, customers are paying more attention not only to the flavor and nutrition of fermented soybean meals, but also to their safety and quality. Mycotoxins, biogenic amine production, and high salt content are among the public health concerns associated with fermented soybean foods. This paper reviews the prevalent concerns about the safety and quality of fermented soybean foods, as well as potential improvements. Attempts and methods have been proposed to ensure the safety of the fermentation process and food quality. Official regulations, the employment of suitable microbes, the use of high-quality cultivars, and the administration of chemicals are all viable options for improving safety and quality. We conclude that implementing international food standards, guidelines, and codes of practice such as the Codex Alimentarius for fermented soybean products and the application of scientific novel methods (e.g., starter combination, high-pressure processing, or low-dose gamma irradiation, additive usage, low salt fermentation technique) are the potential solutions to mitigate the issues and improve the safety and quality of the products.
DAYA HAMBAT DAN DAYA BUNUH EKSTRAK SERBUK BATANG SIWAK TERHADAP BAKTERI STREPTOCOCCUS PYOGENES NUGROHO EKO WIRAWAN BUDIANTO
HANG TUAH MEDICAL JOURNAL Vol 18 No 1 (2020): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

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Abstract

ABSTRACT Background: One of the most growing plants in the Middle East is siwak, which was used to clean teeth. Currently, we have toothpaste that contains siwak as its active ingredient. Previous studies have shown that siwak has anti-bacterial power on Streptococcus faecalis and Streptococcus mutans. This study aims to prove whether the extract of siwak stem powder can be used to inhibit the growth of Streptococcus pyogenes bacteria, one of which can cause pharyngitis. Methods: In this study, the Only Post Test Control Group Design method was used. This study used 24 samples divided into four repetitions (replications) and six treatments. The research used siwak stem extract at a concentration of 100%, 75%, 50% and 25%. Results: It was found that the zone of inhibition of siwak stem powder extract against the growth of Streptococus pyogenes. The mean inhibition zone of the concentrations of 100%, 75%, 50% and 25% was 10.77 mm, 9.77 mm, 8.47 mm and 0 mm. The results of statistical tests showed that the diameter of the bacterial inhibition zone in the K1 group was significantly different against K3, K4, K5, K6, and between the K2 groups against K3, K4, K5, K6 with Pvalue, <0.05. There is no significant difference between K1 and K2 and K3 with K4 and K4 with K5, because the value of Pvalue is> 0.05. Conclusion: The higher the concentration of siwak extract, the wider the inhibition zone will be. At a concentration of 50% the ethanol extract of the siwak stem powder can provide inhibitory power on the growth of the Streptcicoccus pyogenes bacteria. At concentrations of 75% and 100% the inhibition power also increased. At a concentration of 100% it was statistically significant different from the inhibition of amoxicillin.
Ethanol Extract Turmeric (Curcuma domestica val) In Preventing an Increased Grastic Acidity on Rattus norvegicus Which Induced by Histamine Nugroho Eko Wirawan Budianto
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 3, No 1 (2014): Edisi Maret 2014
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (54.862 KB) | DOI: 10.30742/jikw.v3i1.47

Abstract

Gastric ulcer is one of the increase gastric acid causes which mediated by H2 reseptor. Tumeric is extracted using the ethanol 96% and it is tested using Rattus norvegicus Wistar strain to know the effect as anti gastritis. There’s a suspicion whether an ethanol extraction from tumeric which has anti H2 receptor effect can be use to prevent gastric ulcer causes from histamine release. Based on that, we want to study whether tumeric can be use to prevent the increase of histamine induce gastric acid and can also be use as gastric protective by looking at microscopic  image of gastric, gastric pH from Rattus norvegicus Wistar strain.Methods: Male Wistar rats were divided Into five groups: 1) Na CMC control group, 2) CMC Na io histamine plus 300 mg / kg ip groups, 3) ethanol turmeric extract 1000 mg / kg io histamine plus 300 mg / kg ip treated groups, 4) ethanol turmeric extract 2000 mg / kg io histamine plus 300 mg / kg ip treated groups. Rats were sacrified at 6 h after injection of histamine, and stomach tissues were harvested for free acid, total acid, organic acid, pH.Results: Giving P2 ethanol extract of tumeric intra oral decrease free acid level, total acid, organic acid and pH gastric acid which is induced by giving an intra peritoneal histamin. Ethanol extract of tumeric decrease incidence and preventable for ulcus gastric causes by histamin.Conclusion: an ethanol extract of tumeric decrease the levels of free acid, total acid, organic acid and pH gastric. Ethanol tumeric extract 2000 mg/kg is a recommended dosage 
Analisis Pengaruh Pemberian Ekstrak Etanol Buah Rambusa (Passiflora foetida L.) Terhadap Zona Hambat Pertumbuhan Bakteri Escherichia coli Nugroho Eko Wirawan Budianto; Nugrahadi Dwi Pasca Budiono
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 5 No 01 (2023): HERCLIPS VOL 05 NO 1
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v5i01.6205

Abstract

Tumbuhan yang salah satunya berkhasiat di Indonesia adalah Rambusa (Passiflora foetida L.). Buah Rambusa terkandung beberapa zat kimia diantaranya flavonoid, alkaloid, triterpenoid dan steroid yang memberi efek sebagai antibakteri. Tanaman ini bagi masyarakat awam sebagai antibakteri jarang digunakan. Tujuan dari penelitian ini untuk mengetahui aktivitas dan konsentrasi antibakteri yang efektif dari ekstrak buah rambusa terhadap pertumbuhan bakteri Escherechia coli. Metode penelitian ini merupakan penelitian Eksperimental yang menggunakan metode Only Post Test Control Group Design. Uji antibakteri dilakukan dengan menggunakan disc diffusion dengan menggunakan Media Agar Mueller Hinton dengan besar sampel yang diambil adalah 24 sampel dengan masing-masing sampel terdapat 4 kali pengulangan yang terdiri 6 kelompok yaitu konsentrasi uji 20%, 40%, 80%, 100%, kontrol positif (Chloramphenicol) dan kontrol negatif (Aquabidest). Hasil penelitian ini yaitu konsentrasi hambat minimal terhadap pertumbuhan bakteri Escherichia coli di konsentrasi 20% dan 40% adalah 0 mm sedangkan di konsentrasi 80% rata-rata diameter zona hambat 11,75 mm dan juga di konsentrasi 100% rata-rata diameter zona hambat 11,65 mm. Bagian dari kontrol negatif dengan rata-rata diameter zona hambat 0 mm sedangkan kontrol positif dengan rata-rata diameter zona hambat 35,25 mm. Kata kunci: Passiflora foetida L, Escherichia coli, Antibakteri.
Routine hematology description and D-dimer COVID-19 patients at Sidoarjo Regional Hospital Nugroho Eko Wirawan Budianto; Budhi Setiawan; Nugrahadi Dwi Pasca Budiono
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol 13, No 1 (2024): March 2024
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v13i1.3537

Abstract

Background: COVID-19, caused by the SARS-COV-2 virus, is a contagious and potentially fatal disease that is commonly diagnosed using real-time reverse polymerase chain reaction (RT-PCR) assay. Studies have shown that the D-dimer level and the features of hematological exams can offer important prognostic value of the patients. This study aimed to describe data about the routine hematology features and D-Dimer levels of hospitalized COVID-19 patients in Sidoarjo Regional Hospital. Methods: This study used a retrospective, cross sectional, observational approach with descriptive analysis. Medical records of 167 COVID-19 patient were collected based on the criteria. The outcomes of the D-dimer and complete blood count of the patients were summarized. Results: According to the findings, the number of the patients with COVID-19, 53 (31.7%) were between the ages of 31 and 35, and at least 36 (21.6%) were between the ages of 17 and 30. Prominent hematology routine outcomes were the number of patients with anemia (103 or 61.7%), neutrophilia (105 or 62.9%), and lymphocytopenia (129 or 77.2%). The D-dimer value increased by 93 (55.7%) patients among 167 COVID-19 patients. Conclusion: Therefore, monitoring the patient's routine hematological presentation and D-dimer level during treatment is essential for preventing mortality and morbidity.
Efek Pemberian Ekstrak Buah (Passiflora foetida L) Pada Pertumbuhan Bakteri Staphylococcus aureus Budianto, Nugroho Eko Wirawan; Furkani, Agusniar; Budiono, Nugrahadi Dwi Pasca
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol 5 No 02 (2024): HERCLIPS VOL 05 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v5i02.6894

Abstract

Tumbuhan Rambusa (Passiflora foetida L) dapat digunakan sebagai obat. Sebagai antibiotik alami, buah Rambusa memiliki metabolit sekunder yang mengandung flavonoid, alkaloid, tannin, dan saponin, menurut fitokimia. Studi ini mencoba mengetahui apakah ekstrak etanol dari buah rambusa dapat membantu mencegah pertumbuhan bakteri Staphylococcus aureus. Setelah tes penelitian eksperimental ini, desain grup kontrol hanya digunakan. Metode disc diffusion dengan Media Agar Mueller Hinton digunakan untuk melakukan uji antimikroba. Dua puluh empat sampel diambil dan diulang empat kali, dan enam kelompok konsentrasi digunakan untuk menguji kendali positif (Ciprofloxacin), kendali negatif (Aquadest), Konsentrasi uji 20%, 40%, 80%, dan 100%. Hasil penelitian menunjukkan bahwa zona hambat sebesar 32,625 mm pada kendali positif, 0 mm untuk kendali negatif, 0 mm pada konsentrasi 20%, sedangkan pada konsentrasi 40% zona hambat sebesar 11,125 mm, namun untuk zona hambat sebesar 12,875 mm ada pada konsentrasi 100%. Kata kunci : Metabolit Sekunder, Zona Hambat, Ekstrak Buah Rambusa, dan Staphylococcus aureus.
Uji Efektivitas Ekstrak Kunyit Putih (Curcuma Zedoaria Rosc.) dalam Menghambat Bakteri Staphylococcus epidermidis: Uji Efektivitas Ekstrak Kunyit Putih (Curcuma Zedoaria Rosc.) dalam Menghambat Bakteri Staphylococcus epidermidis Budianto, Nugroho Eko Wirawan; Bawahab, Alivia Putri
Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Vol. 6 No. 02 (2025): HERCLIPS VOL 06 NO 02
Publisher : Universitas Muhammadiyah Gresik

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30587/herclips.v6i02.8044

Abstract

Masalah kesehatan di negara tropis salah satunya indonesia yang tidak pernah dapat diobati secara tuntas adalah penyakit infeksi. Penyakit infeksi akibat bakteri yang paling sering dijumpai di lingkungan sekitar adalah jerawat. Staphylococcus epidermidis adalah salah satu bakteri paling banyak menyebabkan penyebab jerawat setelah Propionibacterium acne. Kunyit putih (Curcuma Zedoaria Rosc.) merupakan tanaman yang berkhasiat untuk penyembuhan infeksi. Sebagai obat alami, kunyit putih memiliki kandungan senyawa aktif seperti kurkumin, flavonoid, minyak atsiri, fenolik, dan alkaloid menurut fitokimia. Penelitian ini mencoba untuk mengetahui apakah ekstrak etanol dari kunyit putih mampu mencegah pertumbuhan bakteri Staphylococcus epidermidis. Metode penelitian eksperimental dengan desain post test only control group design menggunakan Metode sumuran. Hasil penelitian menunjukkan bahwa zona hambat sebesar 30,78 mm pada kontrol positif, 0 mm pada kontrol negatif, 34,18 mm pada konsentrasi 20%, 35,38 mm pada konsentrasi 40%, 37,95 mm pada konsentrasi 60%, 41,27 mm pada konsentrasi 80%, dan 36,87 mm pada konsentrasi 100%. Konsentrasi tertinggi yaitu 80% dengan diameter hambat 41,27 mm. Ekstrak kunyit putih (Curcuma Zedoaria Rosc.) dengan konsentrasi (20%, 40%, 60%, 80%, dan 100%) memiliki efektivitas antibakteri terhadap pertumbuhan Staphylococcus epidermidis
Co-Authors Bawahab, Alivia Putri Budhi Setiawan Furkani, Agusniar Hairullah Hairullah, Hairullah Masfufatun Masfufatun Nugrahadi Dwi Pasca Budiono