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All Journal Jurnal Ilmiah Kedokteran Wijaya Kusuma Journal of Herbal, Clinical and Pharmaceutical Science (HERCLIPS) Berkala Penelitian Hayati Hang Tuah Medical Journal Prosiding Seminar Nasional COSMIC Kedokteran Jurnal Widya Medika
NUGROHO EKO WIRAWAN BUDIANTO
Bagian Farmakologi Fakultas Kedokteran Universitas Wijaya Kusuma Surabaya
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Dentistry Environmental Science Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Medicine & Pharmacology Nursing Physics Public Health

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HUBUNGAN USIA DENGAN TINGKAT KECEMASAN PADA PENINGKATAN TEKANAN DARAH Juwono, Benedictus Prayogi Putera; Rianti, Emillia Devi Dwi; Budianto, Nugroho Eko Wirawan
Prosiding Seminar Nasional COSMIC Kedokteran Vol 4 (2026): Edisi 2026
Publisher : Lembaga Penelitian Dan Pengabdian Kepada Masyarakat Universitas Wijaya Kusuma Surabaya

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Abstract

Latar belakang: Usia mempunyai hubungan dengan peningkatan tekanan darah, di mana risiko hipertensi dan kecemasan akan semakin bertambah seiring dengan bertambahnya usia. Tujuan: mengetahui hubungan usia dengan tingkat kecemasan pada peningkatan tekanan darah. Metode: Penelitian dengan kuantitatif menggunakan metode analitik observasional dan rancangan cross sectional, metode pengambilan sampel dengan cara incidental sampling yaitu atas pertimbangan jumlah peserta yang datang berobat pada pemeriksaan posyandu lansia, sampel sebanyak 33. Hasil : responden mempunyai tekanan darah terkontrol yaitu sebanyak 22 orang (66,7%) responden dan sebanyak 11 orang (33,3%) responden lainnya mempunyai tekanan darah tidak terkontrol. Hasil uji chi square diperoleh nilai signifikansi sebesar 0,000 < 0,05, sehingga ada hubungan antara usia dengan tekanan darah. Untuk tingkat kecemasan berdasarkan hasil uji chi square diperoleh nilai signifikansi sebesar 0,606 > 0,05, sehingga tidak ada hubungan antara kecemasan dengan tekanan darah. Kesimpulan: penelitian ini terdapat hubungan usia dengan tingkat kecemasan pada peningkatan tekanan darah di posyandu lansia. Salah satu cara untuk menurunkan tekanan darah pada lansia yang disertai kecemasan ialah pihak posyandu lansia melakukan penyuluhan rutin dan tepat sasaran.
EFFECTIVENESS OF TOMATO LEAF EXTRACT (SOLANUM LYCOPERSICUM) AGAINST THE GROWTH OF STAPHYLOCOCCUS AUREUS Pradipta, Rafly; Budianto, Nugroho Eko Wirawan
JURNAL WIDYA MEDIKA Vol. 12 No. 2 (2026): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwm.v12i2.8250

Abstract

Staphylococcus aureus is a Gram-positive bacterium that commonly causes infections in humans. The increasing prevalence of antibiotic resistance necessitates the exploration of alternative natural antibacterial agents. Tomato (Solanum lycopersicum) leaves contain bioactive compounds such as alkaloids, flavonoids, and phenolics that may exhibit antimicrobial properties. This study aimed to determine the antibacterial effectiveness of tomato leaf extract against S. aureus. A true experimental design was conducted using the disk diffusion method. Tomato leaf extract was prepared in concentrations of 25%, 50%, and 75%. The treatments included a positive control (antibiotic) and a negative control (Aquadest). Inhibition zones were measured after incubation, and data were analyzed statistically to determine significance among groups. The tomato leaf extract demonstrated inhibitory activity against S. aureus at all tested concentrations. The 75% concentration exhibited the strongest inhibition with an average diameter of 20.86 mm (categorized as very strong), followed by 50% (7.86 mm, moderate) and 25% (6.47 mm, moderate). Statistical analysis showed significant differences among all treatment groups (p < 0.05). Tomato (Solanum lycopersicum) leaf extract effectively inhibits the growth of Staphylococcus aureus, with the highest antibacterial activity observed at a 75% concentration. These findings suggest the potential of tomato leaf extract as a promising natural alternative for antibacterial therapy, particularly against antibiotic-resistant strains.
Antibacterial Effectiveness of White Champaca Flower (Michelia alba dc) Against Growth of Corynebacterium diphtheriae Putri, Tiara Nandita; Budianto, Nugroho Eko Wirawan; Tjandra, Lusiani
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 14 No. 1 (2025): MARET 2025
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v14i1.3923

Abstract

Background: Corynebacterium diphtheriae is a bacterium that attacks the respiratory tract, especially the larynx, tonsils, and throat. These bacteria can release toxins that can cause diphtheria. One of the nutritious plants that people often use is the white Champaca flower, or Michelia alba. Objective: This study aimed to examine the antibacterial effectiveness of white champaca flower (Michelia alba dc) against the growth of Corynebacterium diphtheriae. Methods: Experimental research method with post-test only control group design using Cup-plate technique of ethanol extract of white Champaca flower (Micheia alba) in various concentrations (20%, 40%, 60%, 80%, and 100%) and Erythromycin as a positive control and aquades as a negative control. Results: The results of this research are that the minimum inhibitory concentration against the growth of Corynebacterium diphtheriae bacteria at a 20% concentration is 42.16 mm, the concentration of 40% is 47.21 mm, the concentration of 60% is 51.66mm, while at the concentration of 80% the average diameter of the inhibitory zone is 54.49 mm and also at the concentration of 100% the average diameter of the inhibition zone is 54.69 mm which is the average diameter of the largest inhibition zone. The negative control with an inhibitory zone diameter of 0 mm, while the positive control with an inhibitory zone diameter of 44.21 mm. Conclusion: White Champaca flower extract (Michelia alba dc) had antibacterial effectiveness against the growth of Corynebacterium diphtheriae and at a concentration of 100% it is the most effective concentration in inhibiting the growth of Corynebacterium diphtheriae bacteria. 
Effect of Basil Seed Extract (Ocimum basillicum L) on Salmonella Typhi Growth Inhibition Atika Putri Salsabilah; Budianto, Nugroho Eko Wirawan; Yunitati Maria Margaretha Sutandio
Jurnal Ilmiah Kedokteran Wijaya Kusuma Vol. 15 No. 1 (2026): March 2026
Publisher : Universitas Wijaya Kusuma Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30742/jikw.v15i1.4645

Abstract

Background: Basil seeds are a traditional spice with the name Ocimum basalicum L. Basil seed extract contains secondary metabolite compounds such as alkaloids, flavonoids and polyphenols which have the potential to act as antibacterials for Salmonella typhi. The aim of this research was to determine the antibacterial effectiveness of basil seed extract (Ocimum basalicum L) against the growth of Salmonella typhi bacteria. Objective: the aim of the research. Methods: The experimental research method was a post test only control group design using the well diffusion method. Result: The research results showed that the diameter of the inhibition zone formed at successive concentrations of 10%, 20%, 40% and 80% was 27.5 mm, 30.3 mm, 35.6 mm, 40.7 mm against Salmonella typhi. In the One-way Anova test, a p value of 0.000 <0.05 was obtained for the inhibition of the growth of Salmonella typhi bacteria. Conclusion: There is a potential anti-microbial effect of Salmonella typhi bacteria with an optimal concentration of 80%.
Co-Authors Atika Putri Salsabilah Bawahab, Alivia Putri Budhi Setiawan Budiono, Nugrahadi Dwi Pasca Emillia Devi D.Rianti, Emillia Devi Furkani, Agusniar Hairullah Hairullah, Hairullah Juwono, Benedictus Prayogi Putera Lusiani Tjandra Masfufatun Masfufatun Pradipta, Rafly Putri, Tiara Nandita Yunitati Maria Margaretha Sutandio