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All Journal Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Nursin Abd. Kadir
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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ANALISIS CD4 PADA PENATALAKSANAAN PASIEN KOINFEKSI HIV-TB Nursin Abd. Kadir; Nurhayana Sennang; Hardjoeno .
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 16, No 1 (2009)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v16i1.991

Abstract

The Human Immunodeficiency Virus (HIV) epidemic has increased the burden of tuberculosis (TB) among young adults, especially in populations where the prevalence of TB infection is high like Indonesia. TB is the most common opportunistic infection on HIV patients(50%) in developing countries. CD4 also known as T helper lymphocytes are coordinators of body`s immune response, and it has beendeclining in HIV infection and be worsened by TB infection. CD4 count are standard laboratory marker of disease progression to followupandprognosisantiretroviraltherapyinHIVinfection.AimstoseethevalueofCD4countofHIV-TBco-infectedpatientsbeforeandafterantituberculosistogetherwithantiretroviraltherapy.AlongitudinalstudywasconductedbycollectingsecondarydatafromthemedicalrecordandtheresultsofClinicalPathologyLaboratoryofHIV-TBco-infectedpatientsatWahidinSudirohusodoHospitalperiodJuly2007–August2008.DatawereanalyzedbyWilcoxonSignedRankTestandMannWhitneyTestwitha=0.05.Totalsamples(n)were20patients(14patientswithcontinoustherapyand6uncontinoustherapy).WefounddifferentmeansbetweenCD4countbeforeandafterTherapy.CD4countbeforetherapywas71.15±81.04andaftertherapywas114.95±109.71(p=0.089)withWilcoxonSignedRankTest.Theanalyzedwerecontinuedbydividedsamplesincontinousgroupcomparedwithuncontinousgrouptherapy.TheresultshowedtheCD4alterationincontinousgroupwas853.8%anduncontinousgroupwas-56.6%wherep=0.000(MannWhitneytest).CD4counthasincreasedsignificantlyinHIV-TBco-infectedpatients8.5foldfromCD4baselinewithcontinoustherapyandtheuncontinous one has decreased 0.5 fold from CD4 baseline.
FLAMING CELLS DI MULTIPLE MYELOMA Nursin Abd. Kadir; Hj. Darmawaty E.R,; Mansyur Arif
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 17, No 1 (2010)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v17i1.1091

Abstract

Multiple myeloma is a type of cancer on plasma cells which are system of immune cells in bone marrow that produce antibodies. A47 years old man precented with an excruciatingly painfull bone lytic lesion acompanied with compressive fracture in his Thorakal XIIand first Lumbar vertebral body since a week ago. A complete blood count on admission showed anemia normocytic normocrom withhemoglobin content of 5.3 mg/dL. The blood smear revealed clumping of red blood cells to bound "Rouleaux formations". Serum proteinelectrophoresis showed specific evidence of a M-spike. Bence-Jones proteinuria was positive and serum kreatinin arised 2.44 mg/dL.The bone marrow aspiration contained 45% plasma cells, many of which exhibited the morphology of flaming cells with an eccentricnucleus and violaceous cytoplasm. Plasma cells varied in size and shape and included flaming cells and myeloma cells. The patient wasdiagnosed as having flaming cells in multiple myeloma stage IIIB.
Co-Authors Hardjoeno . Hj. Darmawaty E.R, Mansyur Arif Nurhayana Sennang