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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Tofan W Utami
Department of Obstetrics and Gynecology Faculty of Medicine University of Indonesia Jakarta
Health Professions Medicine & Pharmacology Public Health

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Prevalence of High-Risk Human Papillomavirus (HPV) among Negative Visual Inspection of Acetic Acid (VIA): Prevalensi Human Papillomavirus (HPV) Risiko Tinggi pada Hasil Inspeksi Visual dengan Asam Asetat (IVA) yang Negatif Tofan W Utami; Muhammad F Aziz; Gatot Purwoto; Alexander AW Peters; Gert J Fleuren; Vivian Spaans; Sigit Purbadi
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 3, July 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (110.835 KB) | DOI: 10.32771/inajog.v2i3.398

Abstract

Objective: Persistence of high-risk HPV infection is known to be the major cause of cervical cancer. It is important to differentiate the genotype of HPV infection, whether it is high, intermediate or low risk. The aim of this study was to assess the prevalence of high-risk HPV types among Indonesian women with negative VIA. Method: We analyzed cervical swabs from 1,214 patients with negative VIA. By using INNO-Lipa HPV DNA test, we detected the HPV DNA and its genotype. Result: From the 1,214 women with negative VIA, 48 (3.95%) samples were confirmed to have positive HPV DNA by using PCR and electrophoresis. However, hybridization test were not able to detect HPV genotypes in 9 samples. These 9 samples were tested again with PCR and electrophoresis and resulted in negative HPV DNA. Among the remaining 39 samples (3.21%), we detected 19 types of HPV, consisting of 13 types of high-risk HPV, 5 types of low-risk HPV, and 1 type of unknown HPV (type X). Conclusion: Among patients with negative VIA, 3.21% was found to be positive for HPV DNA. From this percentage, the prevalence of high-risk HPV is higher than the low-risk and unknown HPV. Therefore we cannot ignore results of negative VIA, particularly in highrisk group, because there is a slight possibility that presence of HPV can be identified, especially the high risk ones which have a tendency to be persistent. We support the importance of HPV DNA test as cervical cancer screening method. Keywords: cervical cancer, high-risk HPV, negative VIA
Visual Inspection of Acetic Acid (VIA) as a Promising Standard for Cervical Cancer Screening: Inspeksi Visual dengan Asam Asetat (IVA) sebagai Standar Metode Skrining Kanker Serviks yang Menjanjikan Tofan W Utami; Laila Nuranna; Marendra Mahathir; Alexander AW Peters; Gert J Fleuren; Michelle Osse; Sigit Purbadi
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 4, October 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.103 KB) | DOI: 10.32771/inajog.v2i4.411

Abstract

Objective: To evaluate the "false negative" of VIA in our study population compared to HPV DNA test as the reference test or gold standard. Method: We processed the cervical swab from 1,279 patients with negative VIA and detected the HPV DNA by using INNO-Lipa HPV DNA test. Result: From 1,279 women with negative VIA, 65 samples were excluded because of incomplete data and duplicate examination. From the remaining 1,214 women with negative VIA, 39 samples were confirmed to be positive for HPV DNA by both PCR and hybridization, leading to a "false negative" result of 3.21%. Conclusion: This study shows VIA as a very effective method for cervical cancer screening. VIA gives an excellent result, particularly for ectocervix, with minimal cost. Therefore, it is very suitable to be used as cervical cancer screening in developing countries like Indonesia. Keywords: cervical cancer, HPV DNA, negative VIA, screening, VIA
Co-Authors Alexander AW Peters Alexander AW Peters Gatot Purwoto Gert J Fleuren Gert J Fleuren Laila Nuranna Marendra Mahathir Michelle Osse Muhammad F Aziz Sigit Purbadi Sigit Purbadi Vivian Spaans