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All Journal Indonesian Journal of Obstetrics and Gynecology (Majalah Obstetri dan Ginekologi Indonesia)
Sigit Purbadi
Faculty of Medicine, University of Indonesia, Jakarta
Health Professions Medicine & Pharmacology Public Health

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Human Papillomavirus Genotypes and its Prevalence in Normal Population: Genotip Human Papillomavirus dan Prevalensinya pada Populasi Normal Tofan W Utami; Andrijono Andrijono; Laila Nuranna; Darrell Fernando; Alexander AW Peters; Gert J Fleuren; Ekaterina S Jordanova; Sigit Purbadi
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 4, October 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (112.681 KB) | DOI: 10.32771/inajog.v2i4.410

Abstract

Objective: Over 200 types of human papillomavirus (HPV) have been recognized on the basis of DNA sequence. Multiple infection is more prone to be persistent than single infection. The purpose of this study is to assess the variation of HPV types and their prevalence among negative VIA as normal population in Indonesian women. Method: We processed cervical swabs from 1,214 patients with negative VIA. HPV DNA and its genotypes were detected using PCR based INNO-Lipa HPV DNA test. We also classified whether each infection is single or multiple. Result: From 1,214 women with negative VIA, 39 (3.21%) samples were positive for HPV DNA. Among them, we detected 19 types of HPV, consisting of 13 types of high-risk HPV, 5 types of low-risk HPV, and 1 type of unknown HPV (type X). The most prevalent type was HPV type 52 (18.31%), followed by type 39 and X with the same proportion (9.86%), and HPV type 16, 18, and 74 (each 8.45%). Of the total 39 HPV-positive samples, 17 (43.6%) showed multiple-type infection and 22 (56.4%) showed single-type infection. The majority of single infection involves high-risk-HPV. The remaining were type 6, 44, 18, 51 and 66, with each single-type infection showing a prevalence of 4.54%. Conclusion: Our study shows that single HPV infection among the negative VIA population are dominated by high-risk type HPV (types 52, 39, 16, and 18). Single infection was more often encountered than multiple infection. Keywords: HPV DNA, HPV genotypes, multiple infection, negative VIA, single infection
Visual Inspection of Acetic Acid (VIA) as a Promising Standard for Cervical Cancer Screening: Inspeksi Visual dengan Asam Asetat (IVA) sebagai Standar Metode Skrining Kanker Serviks yang Menjanjikan Tofan W Utami; Laila Nuranna; Marendra Mahathir; Alexander AW Peters; Gert J Fleuren; Michelle Osse; Sigit Purbadi
Indonesian Journal of Obstetrics and Gynecology Volume. 2, No. 4, October 2014
Publisher : Indonesian Socety of Obstetrics and Gynecology

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (104.103 KB) | DOI: 10.32771/inajog.v2i4.411

Abstract

Objective: To evaluate the "false negative" of VIA in our study population compared to HPV DNA test as the reference test or gold standard. Method: We processed the cervical swab from 1,279 patients with negative VIA and detected the HPV DNA by using INNO-Lipa HPV DNA test. Result: From 1,279 women with negative VIA, 65 samples were excluded because of incomplete data and duplicate examination. From the remaining 1,214 women with negative VIA, 39 samples were confirmed to be positive for HPV DNA by both PCR and hybridization, leading to a "false negative" result of 3.21%. Conclusion: This study shows VIA as a very effective method for cervical cancer screening. VIA gives an excellent result, particularly for ectocervix, with minimal cost. Therefore, it is very suitable to be used as cervical cancer screening in developing countries like Indonesia. Keywords: cervical cancer, HPV DNA, negative VIA, screening, VIA
Co-Authors Alexander AW Peters Andrijono Andrijono Darrell Fernando Ekaterina S Jordanova Gert J Fleuren Laila Nuranna Marendra Mahathir Michelle Osse Tofan W Utami Tofan W Utami