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All Journal Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Indonesian Journal of Clinical Pathology and Medical Laboratory (IJCPML)
Iskandar Zakaria
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Other

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NITRIT OKSIDA DAN VOLUME EDEMA OTAK PADA STROK PERDARAHAN DALAM OTAK DENGAN POLIMORFISME G894T (Nitric Oxide and Cerebral Edema Volume in Intracerebral Hemorrhagic Stroke with G894T Polymorphism) Iskandar Zakaria; Arif Faisal; Sri Sutarni; Ahmad Hamim Sadewa; Imran Imran
INDONESIAN JOURNAL OF CLINICAL PATHOLOGY AND MEDICAL LABORATORY Vol 22, No 1 (2015)
Publisher : Indonesian Association of Clinical Pathologist and Medical laboratory

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24293/ijcpml.v22i1.1229

Abstract

Nitric Oxide (NO) is a vasodilator that regulates vascular smooth muscle tone. Low levels of NO can cause vasoconstriction andhemodynamic disturbances. In stroke the levels of NO are increased. Endothelial nitric oxide synthase gene polymorphism (eNOS) isbelieved to reduce levels of NO in blood. NO levels decreased in stroke patients with G894T polymorphisms of eNOS gene. Mortality rateof hemorrhagic stroke are increased in case with increased peri focal edema volume. The mechanism of the increased of peri focal edemavolume completely unknown yet, suspected genetics factor. This study was conducted to know the correlation between the NO and perifocal edema volume in stroke with eNOS gene G894T polymorphism by determination. The study was conducted by comparing the levelsof NO and edema volume of intra cerebral hemorrhagic stroke of 46 subjects from Neurology department of dr. Zainoel Abidin generalhospital in Banda Aceh from September 2014 through January 2015 with comparison to ischemic stroke patients the same amount.NO levels checked with Cayman Systems kit following the protocol Griess. G894T polymorphism was determined by PCR-RFLP method.The volume of edema was measured with semi-automatic CT volumetry. Chi Square test was used for comparison of two variables andSpearman correlation test to assess the relationship between the NO and perifocal edema volume. The result is significant, if p valuewas <0.05. The results of these study were levels of NO decreases if there were polymorphism (p=0.001). Peri focal edema volume wasincreased if there were G894T polymorphism (p=0.038). The correlation between low levels of NO and increase of edema volume wasobtained p=0.040 and R=0.304. The researchers concluded that in intra cerebral hemorrhagic stroke the level of NO were decreasedand peri focal edema volume increased if there was G894T polymorphism of eNOS gene. There was a less correlation between low levelsof NO and peri focal edema volume.
DETEKSI DINI TUMOR PAYUDARA DENGAN SADARI DAN PENAPISAN DENGAN ULTRASONOGRAFI DI KOTA BANDA ACEH Teuku Muhammad Yus; Rima Novirianthy; Iskandar Zakaria; Nurul Machillah; Nurhayani Dwi Susanti; Zulkarnain Zulkarnain; Rachmad Suhanda
Jurnal Penelitian dan Pengabdian Kepada Masyarakat UNSIQ Vol. 12 No. 1 (2025): January
Publisher : Lembaga Penelitian, Penerbitan dan Pengabdian Masyarakat (LP3M) UNSIQ

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32699/ppkm.v12i1.7974

Abstract

Kanker payudara salah satu kanker yang paling banyak ditemui pada perempuan di seluruh dunia. Kemenkes RI melaporkan bahwa dari sekitar 26.550 wanita usia 30-50 tahun yang memiliki benjolan pada payudara, 17,64% diantaranya dicurigai kanker payudara. Sementara di Provinsi Aceh dari 1285 wanita usia yang sama dan memiliki keluhan benjolan payudara, 54,1% dicurigai kanker payudara. Kanker payudara menempati peringkat kedua kematian akibat kanker di Indonesia. Angka mortalitas tersebut diperparah dengan fakta bahwa dari 80% kasus kanker payudara di Indonesia terdeteksi saat stadium lanjut. Menanggapi permasalahan tersebut, kami menyelenggarakan penyuluhan metode pemeriksaan payudara sendiri (SADARI) dan dilanjutkan penapisan dengan pemeriksaan ultrasonografi. Tujuan kegiatan ini untuk meningkatkan pengetahuan dan kesadaran masyarakat terhadap pentingnya deteksi dini kanker payudara dan pemeriksaan ultrasonografi payudara. Kegiatan ini melibatkan residen Prodi Radiologi FK USK, Banda Aceh. Hasil pemeriksaan ultrasonografi 12 peserta, 41,67% dengan keluhan dan 58,33% tanpa keluhan, 25% memiliki lesi di payudara dan 75% tidak ditemukan lesi.
Co-Authors Ahmad Hamim Sadewa Arif Faisal Nurhayani Dwi Susanti Nurul Machillah Rachmad Suhanda Rima Novirianthy Sri Sutarni Teuku Muhammad Yus Wiwik Handayani Zulkarnain Zulkarnain