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All Journal Pharmaciana: Jurnal Kefarmasian Jurnal 'Aisyiyah Medika Babul Ilmi Jurnal Ilmiah Multi Science Kesehatan Jurnal Farmasi Sains dan Praktis Jurnal Pengabdian
Galih Pratiwi
STIKES ‘Aisyiyah Palembang
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Optimization transdermal patch of polymer combination of chitosan and HPMC-loaded ibuprofen using factorial designs Shaum Shiyan; Misirti Maulidia Anis Marketama; Galih Pratiwi
Pharmaciana Vol 11, No 3 (2021): Pharmaciana
Publisher : Universitas Ahmad Dahlan

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (872.374 KB) | DOI: 10.12928/pharmaciana.v11i3.19935

Abstract

Ibuprofen is a non-steroidal anti-inflammatory drug that has a disadvantage in its oral use, such as gastrointestinal disorders, nausea, vomiting and gastric ulcers. Transdermal patch dosage forms are an alternative in overcoming this weakness. The transdermal patch is formulated using a special membrane that can control drug release in a matrix system. Therefore, this study optimizes chitosan and HPMC as polymers using a factorial design approach. The parameters tested included weight uniformity, patch thickness, swelling index, in vitro release rate, folding resistance, ibuprofen uniformity, surface pH, and moisture content. The interactions between the components were evaluated using Fourier transform infrared spectrophotometry-attenuated total reflectance (FTIR-ATR). The optimum concentration of chitosan was 0.5% and HPMC 6% with CV values for weight uniformity of 0.003 ± 1.202%; humidity 0.543 ± 5.595%; swelling index 4.611 ± 23,657%; thickness 0.052 ± 2.428%; surface pH 5; durability is less than 300 times and the uniformity of ibuprofen levels is 1.52 ± 2.99%. The design approach using the FFD22 obtained an effective and efficient mathematical-statistical model to determine the optimal polymer combination in the formula. As an additional instrument in design evaluation, the chemometric approach is constructive in modeling and optimization.
EVALUATION OF RESPONSE CORELLATION USING CHEMOMETRICS ANALYSIS FOR PRE-OPTIMIZATION QUERCETIN – SELF EMULSION FORMULATION Shaum Shiyan; Jessica Nathasia; Galih Pratiwi
Jurnal Farmasi Sains dan Praktis Vol 8 No 2 (May-August 2022)
Publisher : Universitas Muhammadiyah Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31603/pharmacy.v8i2.6660

Abstract

The optimization approach using the simplex lattice design (SCD) has many advantages, including a minimized number of experiments and a good description of the interactions between components. However, modeling with the SCD approach has not evaluated between responses. Therefore, this study aims to apply chemometric analysis to evaluate the response from the optimization stage using the quercetin – self emulsion formulations (quercetin-SEFs) as a model. SEFs were prepared using grapeseed oil, croduret, and PEG 400. The evaluated responses included emulsification time and transmittance. Both responses were developed in endurance test by centrifugation method and stability test using freeze-thaw. Chemometric analysis on CA produced a dendrogram, while PCA produced score plots, loading plots, scree plots, and biplots. Emulsification time has a positive correlation with transmittance value. The quercetin-SEFs formula in SCD was classified into three groups based on the similarity of characters. Chemometric analysis was successfully applied in evaluating the response to the quercetin-SEFs optimization modeling.
EVALUASI PENGGUNAAN ANTIBIOTIK PADA PASIEN DEMAM TIFOID DENGAN METODE ATC/DDD Galih Pratiwi; Meri Rosita; Khoirin Khoirin
Babul Ilmi Jurnal Ilmiah Multi Science Kesehatan Vol 14, No 2 (2022): Babul Ilmi Jurnal Ilmiah Multi Science Kesehatan
Publisher : STIKES 'Aisyiyah Palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36729/bi.v14i2.958

Abstract

Latar Belakang: Antibiotik merupakan obat yang paling banyak diresepkan di rumah sakit. Kejadian resistensi penggunaan antibiotik pada terapi tifoid dapat terjadi akibat penggunaan antibiotik yang tidak tepat. WHO menggunakan ATC (Chemical Therapeutic Chemical) dan DDD (Daily Dosis Defined) sebagai standar global untuk studi penggunaan obat, salah satu penggunaan antibiotik menggunakan metode ATC / DDD untuk digunakan. Tujuan: Mengevaluasi penggunaan antibiotik pasien demam tipoid dikaji dari segi kuantitas penggunaannya. Metode: Metode retrospektif dilakukan secara cross sectional, populasi seluruh data rekam medis pasien demam tifoid dirawat inap pada bulan Januari-Juni tahun 2021 sebanyak 32 orang, pengambilan sampel menggunakan teknik purposive sampling berjumlah 32 responden. Penelitian ini dilaksanakan di Ruang Rekam Medis RSUD Pratama Lubai Ulu bulan Mei - Juli tahun 2021. Analisis data menggunakan analisis dekriptif memberikan gambaran dari hasil penelitian yang diperoleh. Pengumpulan data secara univariat. Hasil: Lama perawatan > 0,96 hari, terdapat dua jenis antibiotik dengan penggunaan tertinggi adalah antibiotik Ceftriaxone (59%), dan Cefotaxim (41%), Nilai DDD 100 patients-days antibiotika yang melebihi ketetapan WHO yaitu Ceftriaxone 50,1 dan Cefotaxim 20,2 ada ketidakrasionalan penggunaan antibiotik RSUD Pratama Lubai Ulu Saran: Agar menjadi bahan pertimbangan dalam menetapkan pengobatan pada pasien demam tifoid . Kata Kunci: Antibiotika, Demam tipoid, metode DDD
PENYULUHAN TENTANG BEYOND USE DATE (BUD) PADA OBAT-OBATAN Galih Pratiwi; Aninditha Rachmah Ramadhiani; Yudi Arina; Ulik Alta; Mayang Tari; Onny Indriani; Gerry Nugraha; Suprayetno
Jurnal Pengabdian Vol. 2 No. 1 (2023): Januari-Juni
Publisher : Bengkulu Institute

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58222/jp.v2i1.214

Abstract

Beyond use date (BUD) is the time limit for using a medicinal product after it has been prepared/prepared or afte the primary packaging has been opened/damaged. Primary packaging here means packaging that is in direct contact with medicinal ingredients, such as: bottles, ampoules, vials, blisters, etc. This community service activity aims to provide information and education to the public through outreach activities about Beyond Use Date (BUD). The methods used in this activity were counseling, material presentation, and distribution of leaflets/brochures to all the people who attended the BUD counseling event. It is hoped that service activities can be developed in several other places and that people can use drug rationally.      
EFEKTIVITAS KOMBINASI EKSTRAK DAUN SIRIH HIJAU (PIPER BETLE) DAN DAUN MINT (MENTHA PIPERITA) PADA UJI DAYA HAMBAT BAKTERI STAPHYLOCOCCUS AUREUS Yudi Arina; Galih Pratiwi; Ulik Alta
Jurnal 'Aisyiyah Medika Vol 8, No 2: Agustus 2023 Jurnal 'Aisyiyah Medika
Publisher : stikes 'aisyiyah palembang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36729/jam.v8i2.1107

Abstract

ABSTRAKLatar belakang: Kesehatan rongga mulut memegang peran penting dalam mendapatkan kesehatan umum dan kualitas hidup. Salah satu bakteri yang terdapat dalam rongga mulut adalah bakteri Staphylococcus aureus, Sebagian besar efek antibakteri daun sirih adalah karena daun sirih mengandung 4.2% minyak atsiri yang komponen utamanya terdiri dari bethel phenol dan turunannya yang berkhasiat sebagai antibakteri. Daun mint mengandung minyak atsiri 1-2 %, mentol 80-90 %, menthon, d-pipirition, heksanol fenilasetat, etil amilkarbinol, dan neomentol.Tujuan: Untuk mengetahui ekstrak Daun Sirih (Piper betle) dan  daun (Mentha piperita) memiliki efek antibakteri terhadap pertumbuhan bakteri S.a dengan metode difusi cakram. Metode: Jenis penelitian eksperiment dengan metode difusi cakram dilaksanakan pada bulan Juni-Agustus 2021 di Laboratorium Mikrobiologi Stikes ‘Aisyiyah Palembang. Ekstraksi maserasi di peroleh ekstrak daun sirih hijau 23,9913 g hasil rendemen 23,9913% dan daun mint ekstrak kental 25,4451 g dengan rendemen 25,4451 %. Selanjutnya akan di ujikan pada bakteri S.a   dengan metode difusi cakram. Hasil: Ekstrak tunggal daun mint 7,88±1,379 mm, ekstra tunggal daun sirih hijau 6,64±1,561 mm, dan ekstrak kombinasi 12,44±1,857 mm, Terdapat pengaruh ekstrak tunggal daun mint, ekstrak tunggal daun sirih hijau dan kombinasi memiliki efektivitas antibakteri pada bakteri S.a, dilihat dari hasil zona hambat tersebut. Saran : Perlu dilakukan peneliti lebih lanjut dengan menggunakan berbagai antibiotik yang berbeda. Kata Kunci : Ekstrak, Daun Sirih Hijau, Daun Mint, Staphylococcus aureus
Co-Authors Gerry Nugraha Jessica Nathasia Khoirin Khoirin Mayang Tari Meri Rosita Misirti Maulidia Anis Marketama Onny Indriani Ramadhiani, Aninditha Rachmah Shaum Shiyan Suprayetno Ulik Alta Ulik Alta Yudi Arina Yudi Arina