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All Journal Jurnal Kesehatan dr. Soebandi Indonesian Pharmacopeia Journal (IPJ)
Aliyah Purwanti
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Chemistry Health Professions Medicine & Pharmacology Nursing Public Health

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The Patch Formulation of Rambusa (Passiflora foetida) Leave Extract as Anti-Inflammatory Agent: An In Vitro and In Vivo Study Setyaningrum, Lindawati; Aliyah Purwanti; Widaddhiya Zahra Anggraini; Adelia Royan Suryani; Tolak Haris; Lubis Nuril Ubaidilla
Jurnal Kesehatan dr. Soebandi Vol 12 No 1 (2024): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v12i1.712

Abstract

Rambusa leaves are known to have health benefits, including anti-inflammatory, antitumor, anticancer, antihepatotoxicity and antimicrobial. Rambusa leaves contain active compounds including alkaloids, tannins, saponins, and steroids which have anti-inflammatory effects. So it was developed as a transdermal route preparation in the form of a patch to overcome the problem of side effects from using oral medications on the gastrointestinal tract. Rambusa leaves are formulated into additional ingredients in the form of HPMC, methyl paraben, propylene glycol, 96% ethanol, distilled water and made into ready-to-use patches. Furthermore, an evaluation of the physical quality of the formula was carried out and its anti-inflammatory effectiveness was determined through in vitro and in vivo tests. The results show that each formula produces physical properties that meet the requirements. Apart from that, the results of the in vitro test using sodium diclofenac as a standard show that formulas 100, 200 and 300 are able to penetrate the membrane from the results of the cumulative amount of active ingredients that have been tested, whereas in the in vivo test using wistar rat test, the results of % edema were analyzed using ANOVA and the results of % inhibition were carried out in a post hoc test with LSD. The highest effectiveness was obtained in formula 300, this shows that the formula is capable of inhibiting inflammation. From these results it can be concluded that rambusa leave extract can be developed into a transdermal patch formula for anti-inflammation.
ANTIBACTERIAL ACTIVITY OF ETHANOL EXTRACT OF EDAMAME PEEL AND SEEDS (Glycine max (L.) Merr) AGAINST THE GROWTH OF Staphylococcus aureus Rahmadaniah Affelia; aliyah purwanti; Dhina Susanti
Indonesian Pharmacopeia Journal Vol. 1 No. 2 (2024): July
Publisher : LPPM Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/ipj.v1i2.16

Abstract

Staphylococcus aureus is the cause of acne disease that is resistant to antibiotics in the long term. Edamame is one of the natural ingredients used as an alternative treatment. Edamame seeds have the potential as antibacterial because they contain saponin compounds, in addition edamame peel waste can also be developed as an antibactetrial. The study aims to identify the profile of compound content from edamame peel and seeds extracts, to identify and analyze the antibacterial activity of the extract against Staphylococcus aureus bacteria. Ethanol extract of edamame peel and seeds were obtained from the Ultrasonic Assisted Extraction (UAE) method using 96% ethanol. Each extract was screened for phytochemicals and than made into concentrations of 10%, 20% and 30% to test antibacterial activity using the well diffusion method. Then continued with the One Way Anova test. Ethanol extracts of edamame peel and seeds obtained an average yield of 17,31%±0,57 and 17,10%±0,51. Edamame peel and seeds extracts contain saponins, tannins, steroids, terpenoids, flavonoids dan phenols but edamame seeds do not contain steroid compounds. Edamame peel extract at concentration of 10%, 20% and 30% can inhibit Staphylococcus aureus with an average inhibition zone diameter of 10,13mm±0,54; 12,80mm±0,67 and 14,74mm±0,78 while ethanol extract of edamame seeds produces an average inhibition zone diameter of 9,32mm±0,67; 11,55mm±0,83 and 13,83mm±0,96. The one way Anova test produced a value (Sig.) 0,000 followed by the Post Hoc LSD test showing that there were significant differences between each group. Edamame peel and seeds extracts contain phytochemical compounds such as flavonoids,steroids, phenols, tannins, terpenoidsa and saponins where each compound has a mechanism of inhibiting the growth of Staphylococcus aureus. The antibacterial activity of edamame peel extract is classified as strong at each concentration, while edamame seed extract is classified as strong at concentration of 20% and 30%, than at the concentration of 10% it is classified as moderate.
Co-Authors Adelia Royan Suryani Dhina Susanti lindawati setyaningrum Lubis Nuril Ubaidilla Rahmadaniah Affelia Tolak Haris Widaddhiya Zahra Anggraini