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Sudewi Sudewi
Program Studi Farmasi, Fakultas Farmasi, Universitas Tjut Nyak Dhien
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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UJI AKTIVITAS ANTIBAKTERI SEDIAAN OBAT KUMUR EKSTRAK ETANOL BUAH KAPULAGA (Amomum compactum Sol. ex Maton) TERHADAP PERTUMBUHAN BAKTERI Staphylococcus aureus DAN Streptococcus mutans Vriezka Mierza; Sudewi Sudewi
Journal of Pharmaceutical and Sciences Vol 3 No 1 (2020): JPS Volume 3 Nomor 1 (2020)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v3i1.45

Abstract

Local cardamom (Amomumcompactum Sol. Ex Manton) is able to inhibit the growth of fungi and cineol compounds. Local cardamom which is anti-fungal and contains antibacterial properties. This study aims to determine the ethanol extract of cardamom fruit which is formulated into a mouthwash that can inhibit the growth of bacteria Staphylococcus aureusand Streptococcus mutans at certain concentrations. The method of this research is to test the antibacterial activity of Staphylococcus aureus and Streptococcus mutansfrom the ethanol extract of cardamom mouthwash. The preparation was evaluated for physical stability of storage for 4 weeks, pH test and antibacterial test. All cardamom fruit ethanol extract mouthwash preparations have a good physical form and are stable. At 4 weeks of storage, do not have the appropriate pH and antibacterial activity of cardamom fruit ethanol extract mouthwash against Staphylococcus aureus and Streptococcus mutans 2%, 4%, and 6% for Streptococcus mutans, the inhibition diameter was 9 mm, and 8 mm, while Staphylococcus aureus had the inhibition diameter 12 mm, 11 mm, and 10 mm, respectively. The results of this study concluded that the ethanol extract of cardamom fruit can be formulated into mouthwash with concentrations of 2%, 4%, and 6% which have moderate inhibition against Streptococcus mutans bacteria and have strong category inhibition against Staphylococcus aureus bacteria.
UJI EFEKTIVITAS SEDATIF EKSTRAK ETANOL DAUN RAMBUSA (Passiflora foetida L.) TERHADAP MENCIT JANTAN (Mus musculus) muharni saputri; Sudewi Sudewi; Nurul Karimah; Syarifah Nadia
Journal of Pharmaceutical and Sciences Vol 4 No 2 (2021): JPS Volume 4 Nomor 2 (2021)
Publisher : Fakultas Farmasi Universitas Tjut Nyak Dhien

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36490/journal-jps.com.v4i2.80

Abstract

A common sleep disorder is insomnia, which occurs when a person has difficulty sleeping. One way to deal with insomnia is by giving sedative-hypnotic drugs. One of the plants used as ingredients in traditional medicine is the Rambusa (Passiflora foetida L.) plant. The ethanol extract of rambusa leaves contains alkaloid compounds, saponins, tannins, and steroids. These compounds can provide a sedative effect. This research was conducted to determine the sedative effect of rambusa leaf extract (Passiflora foetida L.) on mice (Mus musculus). This research is an experimental study with a maceration extraction method using 30 mice and divided into 5 groups. Group I (negative control) CMC 0.5%, group II (positive control) Diazepam, groups III, IV, V (treatment) of ethanol extract of rambusa leaves with a dose of 0.16 g / kgBB, 0.34 g / kgBB, 0, 68 g / kgBB. Giving to mice orally and observing body turning reflex, turning time and falling time using the Traction Test. The sedative effect test for each group was statistically analyzed using the SPSS 18.0 Post-Hoc Duncan test method. The results of the One Way ANOVA statistical test showed a significant difference between the treatment groups and the value P=0.000 (P<0.05). In Duncan's Post-Hoc test, doses II and III were not significantly different from diazepam. Doses II and III had the same sedative effect as diazepam. So it can be concluded that the ethanol extract of Rambusa leaves has a sedative effect.
Co-Authors Nurul Karimah Saputri, Muharni Syarifah Aini Vriezka Mierza