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All Journal Jurnal Farmasi Indonesia Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Diyan Sakti Purwanto
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health Veterinary

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Pengaruh Purifikasi Terhadap Kandungan Zat Aktif dan Aktivitas Antioksidan Ekstrak Etanol 50% Daun Kelor (Moringa oleifera L.) Diyan Sakti Purwanto; Hari Susanti; Nining Sugihartini
Jurnal Farmasi Indonesia Vol 18 No 2 (2021): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v18i2.1232

Abstract

Purification extract ethanol 50% of Moringa dry leaves was carried out to increase the active substance content of flavonoids, β-carotene, saponins and tannins which have antioxidant activity. The purpose of this study was to determine the optimal solvent between ethyl acetate and n-hexane in the ethanol extract fractionation of 50% Moringa leaves. The viscous extract obtained was then purified by fractionation. Fractionation was carried out by dissolving the viscous ethanol extract of 50% Moringa leaves (E1) in aquadest of 70ºC and then adding ethyl acetate to a separating funnel to obtain ethyl acetate (E2) fraction. In addition, the viscous ethanol extract of 50 % Moringa leaves (E1) was fractured with n-hexane (E3). The extract and fraction were evaluated for the parameters including the water level of the extract with gravimetry, levels the β-carotene by HPLC and the antioxidant activity with DPPH . Data were analyzed statistically with a confidence level of 95%. The results the water level of the ethanol extract of 50% Moringa leaves is 4.16 with a CV of 4.62%. The β-carotene level on fractured with n-hexane (E3) then ethyl acetate fraction (E2) and ethanol extract 50 % (E1) that is 1.48 ± 0.01%, 1.19 ± 005% and 0.73 ± 0.01%. While antioxidant activity (IC50) were the most optimal in the n-hexane fraction(E3) then ethanol extract 50 % (E1) and ethyl acetate fraction (E2) that is 40.83 ± 0.04 ug/ml, 47.75 ± 0.09 ug/ml and 58.79 ± 0.10ug/ml. The ethanol extract of 50% Moringa leaves and n-hexane fraction were included in the very strong category while the ethyl acetate fraction was included in the strong category so that it has the potential to be an antioxidant.
Penentuan Nilai SPF (Sun Protection Factor) Limbah Destilasi Rimpang Jahe Emprit (Zingiber officinale Var Amarum) dengan Metode Spektrofotometri UV-VIS Nila Ulliyatun Nur Syarofa; Berliansyah Rahmadani Putrianto; Tarisa Martha Sari; Bima Tutus Widiyanto; Selly Agustina; Ulvi Rohmawati; Diyan Sakti Purwanto
Jurnal Ilmu Kedokteran dan Kesehatan Indonesia Vol. 5 No. 3 (2025): November : Jurnal Ilmu Kedokteran dan Kesehatan Indonesia
Publisher : Pusat Riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jikki.v5i3.8148

Abstract

Zingiber officinale Var. Amarum (commonly known as jahe emprit) is a local ginger variety recognized for its richness in bioactive compounds, including flavonoids, phenolics, tannins, saponins, and terpenoids, which are widely reported to possess antioxidant properties and the ability to absorb ultraviolet (UV) radiation. These characteristics highlight its potential as a natural source of photoprotective agents. The present study was conducted to evaluate the Sun Protection Factor (SPF) of ginger rhizome distillation waste and to perform phytochemical screening in order to identify its secondary metabolite content. Distillation was performed on 250 grams of fresh ginger rhizomes using a solvent ratio of 1:2 (b/v). The process yielded 130 mL of liquid waste with a 52% recovery rate and retained the distinctive aromatic profile of ginger. Phytochemical analysis revealed the presence of flavonoids, phenolics, saponins, and phytosterols, while alkaloids were detected only in trace amounts, suggesting the waste still contains valuable bioactive constituents despite undergoing distillation. Determination of SPF was carried out using the Mansur spectrophotometric method, which measures absorbance within the wavelength range of 290–320 nm at 5 nm intervals. The extract demonstrated an average SPF value of 39.29, which is categorized as ultra protection, indicating a very high level of photoprotective capacity. These results confirm that ginger rhizome distillation waste retains compounds with strong UV absorption and antioxidant potential, supporting its use as an active ingredient in sunscreen formulations. Beyond its functional efficacy, the utilization of this by-product also promotes sustainability by reducing waste from the essential oil industry and contributing to eco-friendly cosmetic innovation. In conclusion, the study provides scientific evidence that ginger distillation waste can be valorized into high-value products, offering both environmental and economic benefits while meeting the growing demand for natural and safe alternatives in skincare formulations.
Formulasi Sediaan Gel Variasi Konsentrasi Ekstrak dan Limbah Bunga Mawar Merah (Rosa damascena Mill.) Diyan Sakti Purwanto; Dewi Weni Sari; Diana Tanafasa
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5197

Abstract

Red roses (Rosa damascena Mill.) are known to contain active compounds such as flavonoids, tannins, and vitamin C, which have potential antioxidant and anti-inflammatory properties. However, the utilization of rose flower waste after extraction remains limited. This study aims to formulate and evaluate gel preparations based on red rose extract and post-extraction rose flower waste as an innovation in natural-based topical formulations. This research is an experimental laboratory study using a post-test only design. Three concentration variations were formulated for both the extract (F1, F2, F3) and rose flower waste (F4, F5, F6) using HPMC as the gel base. Physical evaluations included organoleptic testing, homogeneity, pH, adhesion, spreadability, and viscosity. Data were analyzed descriptively and statistically using the Kruskal–Wallis test to determine the effect of concentration variation on physical parameters. All formulations showed good organoleptic and homogeneity results. The pH values were within the safe range for skin (4.75–5.92). Adhesion times met the criteria of >1 second, with a tendency to increase alongside higher concentrations of active ingredients. Spreadability fell within the acceptable range (3–5 cm), decreasing as viscosity increased. The viscosity values ranged from 20,150 to 20,182 cps. There was a significant effect of concentration variation on pH (p < 0.05), adhesion in extract-based gels (p = 0.021), and spreadability in waste-based gels (p = 0.024). In conclusion, gel preparations made from red rose extract and its waste can be successfully formulated with good physical stability and meet standard criteria for topical formulations. Rose flower waste has potential as an alternative active ingredient in the development of natural-based gel products.
Co-Authors Berliansyah Rahmadani Putrianto Bima Tutus Widiyanto Dewi Weni Sari Diana Tanafasa Hari Susanti Nila Ulliyatun Nur Syarofa Nining Sugihartini Selly Agustina Tarisa Martha Sari Ulvi Rohmawati