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All Journal Eureka Herba Indonesia Jurnal Riset Rumpun Ilmu Kedokteran (JURRIKE) Sriwijaya Journal of Internal Medicine Crown: Journal of Dentistry and Health Research
Dewi Weni Sari
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Biochemistry, Genetics & Molecular Biology Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Veterinary

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Potential of Ethanol Extract of Red Gedi Leaves (Abelmoschus manihot L. Medik) Against Endogenous Antioxidant Activity in Rat Model of Diabetes Mellitus Amalia, Annora Rizky; Alfina Nurrahman; Dewi Weni Sari; Muhammad Firdaus
Eureka Herba Indonesia Vol. 5 No. 3 (2024): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v5i3.123

Abstract

Diabetes mellitus (DM) is characterized by chronic hyperglycemia and increased oxidative stress, contributing to disease complications. Red gedi leaves (Abelmoschus manihot L. Medik) are rich in bioactive compounds, including tannins, saponins, alkaloids and flavonoids, with antioxidant potential. This study aims to evaluate the effect of ethanol extract of red gedi leaves on endogenous antioxidant activity in rat model of DM induced by STZ-NA. Male rats were induced with DM with streptozotocin (STZ)-NA. Rats were divided into five groups: normal control (KN), DM control (KDM), glibenclamide positive control (KPG), and group treated with red gedi leaf extract at a dose of 100 mg/kgBW (GEDI 100), 200 mg/kgBW (GEDI 200), and 400 mg/kgBW (GEDI 400). The parameters observed included blood glucose levels, malondialdehyde (MDA) as a marker of oxidative stress, as well as the activity of the antioxidant enzymes superoxide dismutase (SOD), catalase (CAT), and glutathione peroxidase (GPx) in liver tissue. Data analysis used one-way ANOVA and Tukey's post hoc test (p<0.05). The results showed that the yield of ethanol extract from red gedi leaves was 6.984%. Administration of red gedi leaf extract at a dose of 400 mg/kgBW (GEDI 400) significantly reduced blood glucose levels (p<0.05) and MDA (p<0.05), and increased the activity of SOD (p<0.05), CAT (p<0.05), and GPx (p<0.05) in DM rats compared to the DM control group (KDM). The effect of GEDI 400 was comparable to the effect of glibenclamide as a positive control. The ethanol extract of red gedi leaves at a dose of 400 mg/kgBW was effective in increasing endogenous antioxidant activity and reducing oxidative stress in STZ-NA-induced DM rats, showing potential as an antioxidant and antidiabetic agent.
Antibacterial Potential of Dewandaru Leaves (Eugenia uniflora L.) Against Escherichia coli: In Vitro Study Setiyanto, Riyan; Annisa Diyan Meitasari; Sinta Cantika Natasya; Dewi Weni Sari
Sriwijaya Journal of Internal Medicine Vol. 2 No. 2 (2024): Sriwijaya Journal of Internal Medicine
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/sjim.v2i1.138

Abstract

Introduction: Escherichia coli is a pathogenic Gram-negative bacteria that commonly causes digestive tract infections, including diarrhea. Continuous use of antibiotics has led to an increase in bacterial resistance. Dewandaru leaves (Eugenia uniflora L.) have been known to have antibacterial activity against several pathogenic bacteria. This study aims to evaluate the antibacterial activity of dewandaru leaf extract against E. coli in vitro. Methods: Dewandaru leaves were extracted using the maceration method with 96% ethanol. The antibacterial activity test was carried out using the Kirby-Bauer disk diffusion method with gentamicin as a positive control and sterile NaCl as a negative control. The diameter of the inhibition zone was measured and analyzed statistically. Results: Dewandaru leaf extract shows antibacterial activity against E. coli with a significant zone of inhibition. An extract concentration of 80% showed moderate antibacterial activity, while concentrations of 40% and 60% did not show antibacterial activity. Conclusion: Dewandaru leaves have the potential to be a natural antibacterial agent against E. coli. Further studies are needed to isolate and identify the active compounds and evaluate the effectiveness and safety of dewandaru leaf extract in vivo.
Antibacterial Test of Cherry Leaves Ethanol Extract (Muntingia calabura L.) Against Streptococcus mutans Amalia, Annora Rizky; Riyan Setiyanto; Alfina Nurrahman; Ariska Rahmawati Utami; Dewi Weni Sari
Crown: Journal of Dentistry and Health Research Vol. 2 No. 1 (2024): Crown: Journal of Dentistry and Health Research
Publisher : Phlox Institute: Indonesian Medical Research Organization

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59345/crown.v2i1.128

Abstract

Introduction: Streptococcus mutans is a bacteria that plays an important role in the occurrence of dental caries. Use of antibiotics to treat infections Streptococcus mutans often causes side effects. Cherry leaves (Muntingia calabura L.) contain active compounds that have the potential to have antibacterial effects. This research aims to determine the inhibitory power of cherry leaf ethanol extract against Streptococcus mutans in vitro. Methods: This research uses an experimental method with a post-test-only control group design. Cherry leaf ethanol extract was made by maceration method using 96% ethanol solvent for 5 days. The antibacterial test was carried out using the paper disc diffusion method with varying concentrations of cherry leaf extract, namely 20%, 40%, and 60% w/v dissolved in 10% DMSO. The positive control used was the amoxicillin antibiotic disc, while the negative control used 10% DMSO. Results: The results of the antibacterial test of the ethanol extract of cherry leaves in this study showed that at a concentration of 20% it had an average inhibitory power of 9.16 mm, the extract with a concentration of 40% had an inhibitory power of 11.33 mm, and at a concentration of 60% it had an inhibitory power of 12. 16mm. The positive control amoxicillin had an inhibitory power of 18.67 mm. Conclusion: Cherry leaf ethanol extract has potential as an alternative therapy to overcome Streptococcus mutans bacterial infections.
Formulasi Sediaan Gel Variasi Konsentrasi Ekstrak dan Limbah Bunga Mawar Merah (Rosa damascena Mill.) Diyan Sakti Purwanto; Dewi Weni Sari; Diana Tanafasa
JURNAL RISET RUMPUN ILMU KEDOKTERAN Vol. 4 No. 1 (2025): April : Jurnal Riset Rumpun Ilmu Kedokteran
Publisher : Pusat riset dan Inovasi Nasional

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55606/jurrike.v4i1.5197

Abstract

Red roses (Rosa damascena Mill.) are known to contain active compounds such as flavonoids, tannins, and vitamin C, which have potential antioxidant and anti-inflammatory properties. However, the utilization of rose flower waste after extraction remains limited. This study aims to formulate and evaluate gel preparations based on red rose extract and post-extraction rose flower waste as an innovation in natural-based topical formulations. This research is an experimental laboratory study using a post-test only design. Three concentration variations were formulated for both the extract (F1, F2, F3) and rose flower waste (F4, F5, F6) using HPMC as the gel base. Physical evaluations included organoleptic testing, homogeneity, pH, adhesion, spreadability, and viscosity. Data were analyzed descriptively and statistically using the Kruskal–Wallis test to determine the effect of concentration variation on physical parameters. All formulations showed good organoleptic and homogeneity results. The pH values were within the safe range for skin (4.75–5.92). Adhesion times met the criteria of >1 second, with a tendency to increase alongside higher concentrations of active ingredients. Spreadability fell within the acceptable range (3–5 cm), decreasing as viscosity increased. The viscosity values ranged from 20,150 to 20,182 cps. There was a significant effect of concentration variation on pH (p < 0.05), adhesion in extract-based gels (p = 0.021), and spreadability in waste-based gels (p = 0.024). In conclusion, gel preparations made from red rose extract and its waste can be successfully formulated with good physical stability and meet standard criteria for topical formulations. Rose flower waste has potential as an alternative active ingredient in the development of natural-based gel products.
Co-Authors Alfina Nurrahman Amalia, Annora Rizky Annisa Diyan Meitasari Ariska Rahmawati Utami Diana Tanafasa Diyan Sakti Purwanto Muhammad Firdaus Riyan Setiyanto Setiyanto, Riyan Sinta Cantika Natasya