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All Journal journal of internal medicine Indonesian Journal of Rheumatology Jurnal Penyakit Dalam Udayana
Tjokorda Raka Putra
Rheumatology Division, Department Of Internal Medicine, Faculty Of Medicine, University Of Udayana, Sanglah Hospital
Immunology & microbiology Medicine & Pharmacology Public Health

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KORELASI KADAR MATRIX METALLOPROTEINASES 3 (MMP-3) DENGAN DERAJAT BERATNYA OSTEOARTRITIS LUTUT Eka Imbawan, IGN; Raka Putra, Tjokorda; Kambayana, Gede
journal of internal medicine Vol. 12, No. 3 September 2011
Publisher : journal of internal medicine

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (136.187 KB)

Abstract

Osteoarthritis (OA) is one type of arthritis which commonly found especially in elderly and become the common cause ofdisability in elderly people. Recently known that immunologic respons and homeostasis of cartilage metabolism have animportant role, and MMP-3 as one of degradative enzyme which has a pivotal role in OA patogenesis. Aim of this studyis to determine correlation between level of MMP-3 and radiographic grading of knee OA, in Sanglah Hospital, DenpasarBali. An analytical cross sectional study was carried out in Policlinic Sanglah Hospital, enrolled 76 samples with kneeOA. Of all sample, 32 (42.1%) were males and 44 (57.9%) famales. The mean of MMP-3 serum level is 25.2 ± 20.7ng/ml. Radiographic grading of knee OA based on Kelgren and Lawrence criteria 4 (5.3%) grade 1,29 (38.3%) grade 2,28 (36.8%) grade 3 and 15 (19.7%) grade 4. The mean level of MMP-3 on grade 1 group is (24.7 ng/ml), grade 2 (17.8ng/ml), grade 3 (28.3 ng/ml) and grade 4 is 32.8 ng/ml. Using Spearman!s analyses, there were signiÞ cant correlationbetween MMP-3 and radiographic grading of knee OA (r = 0.25 and p = 0.03).There were signiÞ cant positive correlation between MMP-3 and radiographic grading of knee OA.
The Relationship between Neutrophil Lymphocyte Ratio with Disease Activity in Systemic Lupus Erythematosus Gede Kambayana; I Gusti Agung Friskha Surya Putra; Pande Ketut Kurniari; Tjokorda Raka Putra
Indonesian Journal of Rheumatology Vol. 11 No. 1 (2019): Indonesian Journal of Rheumatology
Publisher : Indonesian Rheumatology Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ijr.v11i1.126

Abstract

Background. Systemic Lupus Erythematosus (SLE) is an Autoimmune inflammatory disease that is systemic and chronic inflammation with heterogeneous of history, clinical manifestations, and prognosis. The disease activity of SLE has been proven as a predictor of organ damage and death by evidenced of inflammatory markers involved in this disease. Neutrophil to Lymphocyte Ratio (NLR) is useful for estimating the activity of autoimmune disease and inflammation that easily obtained from blood test and low cost and measurable as new biomarker to assess inflammatory response or activity of SLE. This study aimed to determine the relationship between NRL and Disease Activity based on Mex-SLEDAI in patients SLE. Methods. This study is an analytic study with cross sectional design. It started from November 2016 until March 2017. Mex-SLEDAI and blood sampling used in this study. Result. Total sample in this study is 54 patients with median age was 28.5 years, with mostly female (85,2%). Result analysis with positive correlation between NLR with disease activity on SLE (r=0.399 p=0.003 n=54), thus the Scatter plot shows there is a correlation between NRL with Mex-SLEDAI. Conclusion. Positive correlation between NLR and disease activity of the SLE, the higher of the disease activity/Mex-SLEDAI will be followed by the increase of NLR.
Co-Authors A Halim Ali Djamhuri Gede Kambayana Hensen - I Gusti Agung Friskha Surya Putra I K Rina I Made Rama Putra I Wayan Dary IGN Eka Imbawan Indrawan, IGNM Budiana Ketut Andriyasa Pande Ketut Kurniari Tonny, Tonny