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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Jurnal Kedokteran Brawijaya MNJ (Malang Neurology Journal) Heart Science Journal Journal of Psychiatry Psychology and Behavioral Research (JPPBR) Engagement: Jurnal Pengabdian Kepada Masyarakat
Novi Kurnianingsih
Brawijaya Cardiovascular Research Center Department Of Cardiology And Vascular Medicine Faculty Of Medicine, Universitas Brawijaya Malang
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Modifying Effect of Anthocyanin from Purple Sweet Potatoes on Visceral Fat Tissue Inflammation and Liver Oxidative Stress in Psychological Stress-Induced Mice: Purple Sweet Potatoes on Psychological Stress Nia Kurnianingsih; Dian Artamevia; Antania Kashira Winarta; Andini Putri Wulandari; Dian Hasanah; Edwin Widodo; Retty Ratnawati
Journal of Tropical Life Science Vol. 13 No. 2 (2023)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.13.02.18

Abstract

Psychological stress generates inflammation and oxidative stress in various tissues. Visceral fat as the target site of inflammation is then correlated with stress-induced obesity. Redox imbalance following inflammation also has prominent impacts on hepatic tissue. Therefore, the development of anti-inflammatory and antioxidant properties from plant bioactive compounds is necessary to be investigated. Anthocyanin (ANC) from various plants is previously described as a powerful anti-inflammatory and antioxidant even though its effect in psychological stress remains underexplored. Purple sweet potatoes (PSP) has ANC as its natural pigment. Previous studies revealed the potential effect of ANC from PSP on behavior and an antidepressant candidate. Thus, this study was purposed to determine the effect of ANC from PSP on inflammation and oxidative stress in visceral fat and hepatic tissue respectively. A total of 25 adult male BALB/c mice were assigned into groups of control, stress, stress+ANC 10 mg/kgBW, stress+ANC 20 mg/kgBW and stress+ANC 40 mg/kgBW. Restraint stress was applied 2 hours/day for 14 days. Enzyme-linked immunoassay (ELISA) was conducted to measure level of IL-6 and IL-10 in visceral fat as well as SOD and MDA from hepatic tissue. The results demonstrated that the supplementation of ANC reduces the level of IL-6 cytokine (p=0.005), tends to increase IL-10 (p=0.612), reduces hepatic SOD (p=0.03), and does not significantly affect the level of hepatic MDA (p=0.432). Both ratios of IL-6/IL-10 and SOD/MDA were reduced following ANC administration. Total ANC extracts are suggested to have a potential role of resisting inflammation and oxidative stress in the psychologically stressed model. Further studies are necessary to evaluate the benefits of ANC from PSP in other peripheral organs under psychological stress exposure.
Co-Authors Adhika Prastya Wikananda Agustin Iskandar Andini Putri Wulandari Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Anna Fuji Rahimah Antania Kashira Winarta Ardian Rizal Aris Munandar Zulkifli Ismail Aris Widayati Ayu Asri Devi Adityawati Budi Satrijo Budi Satrijo Cholid Tri Tjahjono Davy Reyhanditya Dian Artamevia Dian Hasanah Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Djanggan Sargowo Dyah Ayu Ikeningrum Edwin Widodo Eko Suyanto Fahmy Rusnanta Fatchiyah Fatchiyah Fatchiyah Fatchiyah Heny Martini Indra Prasetya Indra Prasetya Irma Kamelia Irma Kamelia Liemena Harold Adrian Mohammad Ryan Ramadhan Mohammad Saifur Rohman Monika Sitio Muhammad Rizki Fadlan Mustika Dewi Oktafin Srywati Pamuna Putri Annisa Kamila Retty Ratnawati Riskawati, Yhusi Karina Safitri, Anna Sasmojo Widito Seprian Widasmara Veny Kurniawati Viona Faiqoh Hikmawati Zainal Fathurohim