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All Journal Molekul: Jurnal Ilmiah Kimia BioEksakta : Jurnal Ilmiah Biologi Unsoed Jurnal Impresi Indonesia
Hernayanti Hernayanti
Universitas Jenderal Soedirman
Religion Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Economics, Econometrics & Finance Education Immunology & microbiology Law, Crime, Criminology & Criminal Justice Social Sciences Veterinary

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Anti-inflammatory Test of Centella Asiatica Extract on Rat Induced by Cadmium Hernayanti Hernayanti; Sri Lestari; Saryono Saryono; Puji Lestari
Molekul Vol 16, No 3 (2021)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (228.654 KB) | DOI: 10.20884/1.jm.2021.16.3.775

Abstract

Cadmium is  a toxic heavy metal. The present of cadmium caused inflammation in liver. This study aims to know the anti inflammatory of Centella asiatica extract on rat induced by cadmium. This research was an experimental study using post test only control group design. Twenty four rats divided into six groups  with four replications, i.e group of healthy control (C1), negative control induced by CdSO4 with dosage 56 mg/kg for 14 days and treatment (C3-C6) with dosage of 100, 200 ,300 and 400 mg/kg of C. asiatica. The blood Cd, GST, GSH, TNF- α and COx2 were measured after a 21 days administration of C. asiatica. The data were analyzed by ANOVA test followed by Duncan test with a significance level of 5%. The result showed that administrating C.asiatica can neutralized cadmium, improve inflammation in liver.The conclusion of our research that C.asiatica extract can decrease Cd level, TNF-α and COx2 levels and increase GST and GSH level in rat induced by cadmium. A 200 mg/kg was the effective dosage to reduce Cd, TNF-α and COx2 levels and increase GST and GSH levels. Key words : anti inflammatory, Cd, Centella asiatica, GST, COX2
POTENSI EKSTRAK ETIL ASETAT Coprinus comatus TERHADAP KADAR UREUM DAN KREATININ PADA TIKUS PUTIH MODEL DIABETES Anik Laeli Perdanawati; Nuniek Ina Ratnaningtyas; Hernayanti Hernayanti
BioEksakta : Jurnal Ilmiah Biologi Unsoed Vol 3 No 3 (2021): BioEksakta
Publisher : Fakultas Biologi Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20884/1.bioe.2021.3.3.4239

Abstract

Coprinus comatus or chicken drumstick mushrooms has potential as antioxidant and antidiabetic. Hyperglycemia in people with diabetes mellitus causes an increase in Reactive Oxygen Species (ROS). Pancreatic β cells have less antioxidants than other organs. This causes oxidative stress which triggers a chain reaction of lipid peroxidation which damages the kidneys and disturbs the glomerular filtration rate. Impaired glomerular filtration rate is characterized by increased levels of urea and creatinine. Flavonoids in C. comatus are able to donate H + and stop lipid peroxidation reactions in the kidneys, so that urea and creatinine levels decrease.This study aims to determine the effect of C. comatus ethyl acetate extract on blood urea and creatinine levels in diabetic rats and to determine the effective dose of C. comatus ethyl acetate extract on blood urea and creatinine levels in diabetic rats. This study used an experimental method based on a completely randomized design (CRD). The data obtained from the measurement of urea and creatinine levels were analyzed using the one way Anova statistical test at the 95% confidence level and followed by Duncan's test at an error rate of 5%. The results of this study indicated that the ethyl acetate extract of C. comatus affected the blood urea and creatinine levels of diabetic rats. C. comatus extract at a dose of 500 mg/kgBW is an effective dose that has an effect on reducing levels of blood urea and creatinine in the amount of 16,66 ± 0,00 mg/dL dan 0,40 ± 0,12 mg/dL.
Assessment of Greenhouse Gas (GHG) Emissions in the Coal Mining Services Operations of PT Antareja Mahada Makmur Deni Rahman Saputra; Probo Hardini; Hernayanti Hernayanti
Jurnal Impresi Indonesia Vol. 5 No. 4 (2026): Jurnal Impresi Indonesia
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/jii.v5i4.7730

Abstract

The mining industry plays a substantial role in driving the increase of greenhouse gas (GHG) emissions in Indonesia, particularly through deforestation and the intensive use of fossil fuels. Consequently, evaluating GHG emissions from mining companies is essential for determining appropriate mitigation strategies. This study aims to assess the greenhouse gas emission profile within the coal mining service operations of PT Antareja Mahada Makmur. The assessment provides important insights into the environmental footprint of coal mining activities, which serve as a basis for guiding sustainable operational practices and ensuring compliance with environmental regulations. The findings indicate a notable escalation in total emissions from both mobile sources over the period from January 2025 to December 2025. Carbon dioxide (CO?) was identified as the predominant greenhouse gas emitted, especially from mobile equipment operations. These results underscore the urgency of implementing targeted mitigation measures, including enhancing energy efficiency and integrating renewable energy alternatives, to reduce the sector’s overall emission levels. Furthermore, this research offers valuable contributions in identifying emission-related challenges and proposing improvements that support corporate efforts toward achieving GHG reduction targets.
Co-Authors Anik Laeli Perdanawati Deni Rahman Saputra Nuniek Ina Ratnaningtyas Probo Hardini Puji Lestari Saryono Saryono Sri Lestari