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All Journal HAYATI Journal of Biosciences Journal of Tropical Crop Science Jurnal Jamu Indonesia Jurnal Kedokteran Hewan Jurnal Tumbuhan Obat Indonesia
Taopik Ridwan
Biopharmaca Study Centre, Institute of Research and Community Services, Bogor Institute of Agriculture
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Earth & Planetary Sciences Immunology & microbiology Medicine & Pharmacology Public Health Veterinary Other

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Increasing Growth Rate and Production of Bioactive Compounds Curcuminoid and Xanthorrhizol in Javanese Turmeric (Curcuma xanthorrhiza Roxb.) Rhizomes with Biso Zyme Application Aziz, Sandra Arifin; Ridwan, Taopik; Batubara, Irmanida
Journal of Tropical Crop Science Vol 5 No 3 (2018): Journal of Tropical Crop Science
Publisher : Department of Agronomy and Horticulture, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (731.959 KB) | DOI: 10.29244/jtcs.5.3.103-110

Abstract

The bioactive compounds from Javanese turmeric (Curcuma xanthorrhiza Roxb.), curcuminoid and xanthorrhizol, have been used to treat human diseases. This research aims to study the Javanese turmeric growth, its curcuminoid and xanthorrhizol content using Biso Zyme with different concentration and interval spraying. Biso Zyme is is conjugated enzyme concentrate (CEC) produced by yeast extracts that can be applied to the plant to increase and improve plant yields. The treatments were arranged in a randomized block factorial design with three replications. The concentrations of Biso Zyme were 0.0, 0.1, and 0.05 %, with monthly spraying intervals at 1, 2, 3, 4 and 5 months after planting (MAP). The results showed that the highest leaf area index was 2.71 cm2g-1  followed by leaf area ratio which was 66.47 cm2.g-1 with 0.1% Biso Zyme application. Relative growth rate was 0.048 g.day-1while net assimilation rate was 0.00092 g.cm-2.day-1 without Biso Zyme application. The highest fresh and dry weight was those treated with 0.05% Biso Zyme applied at 4 to 5 MAP, i.e., 444.44 g and 68.72 g, respectively. The highest curcuminoid and xanthorrhizol contents were 0.435% and 1.505%, respectively, with 0.05% Biso Zyme spraying interval at 4 to 5 MAP, and 0.1%  Biso Zyme with sprayed at 1 to 5 MAP. Thin layer chromatography (TLC) analysis detected standard curcuminoid at Rf 0.23 and xanthorrhizol at Rf 0.66 with dichloromethane:chloroform eluents. Keywords: curcuminoid, Javanese turmeric, Leaf Area Index, organic fertilizer, xanthorrhizol 
PHENOLIC AND FLAVONOID PRODUCTION, PHYTOCHEMICAL PROFILE, AND ANTIOXIDANT CAPACITY OF Adenostemma platyphyllum AT DIFFERENT CONCENTRATIONS OF HYDROPONIC SOLUTIONS : Produksi Fenolik dan Flavonoid, Profil Fitokimia, dan Kapasitas Antioksidan Adenostemma platyphyllum pada Konsentrasi Larutan Hara Hidroponik Berbeda Tamsin, Aqlia Hanna Nurfatiha; Batubara, Irmanida; Ridwan, Taopik; Trivadila; Aziz, Sandra Arifin
Jurnal Tumbuhan Obat Indonesia Vol. 16 No. 1 (2023): July 2023
Publisher : Universitas Tidar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31002/jtoi.v16i1.552

Abstract

Adenostemma platyphyllum is considered a weed with various benefits but has not been widely cultivated. This work aims to obtain the optimum concentration of a nutrient solution (AB-mix) to produce optimum phenolic and flavonoid levels, antioxidant capacity and metabolite profiling in A. platyphyllum using a hydroponic wick system. Different AB-mix nutrient solution concentrations were employed in a one-factor randomized block design. The highest total phenolic, flavonoid concentrations and antioxidant capacity were found in plants without additional nutrient solutions. However, the highest phenolic and flavonoid productivity was found in plants with a nutrient solution concentration of 1100 mg/L. The phenolic/flavonoid group compounds were successfully identified by separating the components using thin-layer chromatography. The intensity of the bands produced from each treatment was quite varied. The untreated plant produced thicker phenolic/flavonoid bands than the other treatments. This was supported by the heatmap pattern produced by the untreated ones, which had high color intensity. Therefore, the optimum concentration of nutrient solution to produce optimum phenolic, flavonoid levels, and antioxidant capacity in A. platyphyllum cultivation by hydroponic wick system was the concentration of 1100 mg/L.
LC-HRMS-Based Metabolomics for Profiling the Metabolites in Different Plant Parts of Centella asiatica Rafi, Mohamad; Madya, Muhammad Miftahul; Karomah, Alfi Hudatul; Septaningsih, Dewi Anggraini; Ridwan, Taopik; Rohaeti, Eti; Aisyah, Siti; Idroes, Rinaldi
HAYATI Journal of Biosciences Vol. 31 No. 6 (2024): November 2024
Publisher : Bogor Agricultural University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.4308/hjb.31.6.1106-1115

Abstract

Centella asiatica, or pegagan in Indonesia, is a perennial plant used in Indonesian traditional medicine (jamu) and functional food with many biological activities. Those biological activities come from the bioactive metabolites present in C. asiatica. Differences in metabolite pathways in each part of the plant affect the accumulation of metabolites contained, thus impacting its biological activity. Therefore, this study aims to identify and evaluate differences in the distribution of metabolites in each part of C. asiatica, namely leaves, stems, stolons, and roots. Each plant part was extracted using methanol and sonicated for 30 minutes. The metabolites in the samples were separated and detected using UHPLC-Q-Orbitrap HRMS. Differences in the distribution of metabolites in each part of the plant were evaluated using chemometrics analysis. UHPLC-Q-Orbitrap HRMS analysis could positively identify 37 metabolites, most of which belong to the phenylpropanoid, triterpenoid, triterpenoid saponin, and flavonoid groups. Principal component analysis was able to clearly distinguish each part of the plant using the peak intensity of the overall chromatogram and the peak area of the identified metabolites. The different biosynthetic pathways of metabolites in plants could cause a difference in the distribution of metabolites in each plant.
Growth, Phenolic, and Flavonoid Production of Adenostemma platyphyllum at Different Dosages of Cow Manure Ridwan, Taopik; Ananda, Fira; Maulana, Faizal; Takemori, Hiroshi; Azis, Sandra; Batubara, Irmanida
Jurnal Jamu Indonesia Vol. 9 No. 3 (2024): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v9i3.318

Abstract

Adenostemma platyphyllum is a weed plant containing various secondary metabolites, such as phenolics and flavonoids, making it essential to cultivate properly. This study aims to determine the optimal cow manure dosage for plant growth, focusing on phenolic and flavonoid production in the cultivation of A. platyphyllum. The experiment employed a randomized complete block design (RCBD) with a single factor: cow manure doses of 0.5, 5, 10, 15, and 20 ton/Ha. Phenolic content was measured using the Folin Ciocalteu reagent, while flavonoid content was assessed using the AlCl₃ reagent. Results indicate that the highest phenolic and flavonoid production occurred in plants treated with 20 ton/Ha manure. This dosage also resulted in the best plant growth, yielding the highest crop, number of leaves, and branches compared to other treatments.
Optimizing Growth and Flavonoid Production in Kaempferia angustifolia Using Organic (Chicken and Cow Manure) and Inorganic Fertilizers Aziz, Sandra Arifin; Ridwan, Taopik; Iswantini, Dyah; Trivadila, Trivadila; Murni, Anggia; Rafi, Mohamad
Journal of Tropical Crop Science Vol. 12 No. 02 (2025): Journal of Tropical Crop Science
Publisher : Department of Agronomy and Horticulture, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jtcs.12.02.365-377

Abstract

Kaempferia angustifolia originated in Southeast Asia and is widely used for its medicinal properties. One of which is from its flavonoids. The research aims to determine the optimal dosage of organic and inorganic fertilizers for promoting the growth and flavonoid production of K. angustifolia. The study was laid out in a split-plot design using organic fertilizers as the main plots (chicken and cow manure at 10 t.ha-1) and inorganic fertilizers as the subplots, consisting of 19 combinations of urea, SP36, and KCl. Each treatment has three replications.  The results showed that there is no interaction between organic and inorganic fertilizers in affecting the growth of Kaempferia angustifolia. Plants treated with chicken manure at 10 tons per hectare have a higher fresh weight than those treated with cow manure. Plants without inorganic fertilizer application showed suppressed growth and yielded more rhizomes three months after planting. Inorganic fertilizer promoted more shoots and tillers, with the highest value obtained from 100 kg.ha-1 urea + 200 kg.ha-1 SP36 + 200 kg.ha-1 KCl application.   The range of total flavonoids in inorganic fertilizer applications is 39.30-131.51% higher than the control, with the highest value observed at 200 kg.ha-1 SP36 + 200 kg.ha-1 KCl application. The results of this study would be useful for producing K. angustifolia for the medicinal industry, using either organic or inorganic fertilizers.
INSTANT GRANULES OF Zingiber officinale AND Cajanus cajan LEAVES IMPROVED LIVER HISTOLOGICAL PROFILE IN DIABETIC MODEL RATS Manalu, Johanes Marojahan; Sadiah, Siti; Aziz, Sandra Arifin; Astawan, Made; Ridwan, Taopik; Wresdiyati, Tutik
Jurnal Kedokteran Hewan Vol 19, No 3 (2025): September
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v19i3.47330

Abstract

Diabetes mellitus can cause significant microstructural damage in liver tissue. This study evaluated the effectiveness of instant granules of Zingiber officinale and Cajanus cajan leaves on the liver histological profile in diabetic model rats. A total of 25 male Sprague Dawley rats were assigned into five groups. The group consist of negative control (NC), positive control (PC), metformin control group at a dose of 150 mg/kg BW (MET), and two treatment groups of instant granules of Z. officinale and C. cajan leaves at a dose of 300 mg/kg BW (T1) and 150 mg/kg BW (T2) for 28 days treatment. The diabetic condition was obtained by single induction of streptozotocin (35 mg/kg BW). The liver tissue was stained using hematoxylin-eosin staining to observe the cytoplasm intensity, central vein diameter, and nucleus intensity of liver cells in diabetic model rats. The results showed that administration of the instant granules significantly decrease liver microstructural damage (P0.01). The 150 mg/kg BW (T2) dose showed the most optimal effectiveness by successfully decreasing cytoplasmic intensity, reducing central vein dilation, and decreasing nuclear cell intensity. The research result indicate that instant granules have strong hepatoprotective properties that can repair liver microstructural damage caused by diabetes.
Co-Authors . TRIVADILA Ananda, Fira Anggia Murni Azis, Sandra Dyah Iswantini Eti Rohaeti Irmanida Batubara Karomah, Alfi Hudatul M. Rafi MADE ASTAWAN Madya, Muhammad Miftahul Manalu, Johanes Marojahan Maulana, Faizal Rinaldi Idroes Sandra Arifin Aziz Septaningsih, Dewi Anggraini Siti Aisyah Siti Sadiah Takemori, Hiroshi Tamsin, Aqlia Hanna Nurfatiha Tutik Wresdiyati