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All Journal PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Molekul: Jurnal Ilmiah Kimia
Dhadhang Wahyu Kurniawan
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Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology

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No Acute Toxicity Tests of Purwoceng (Pimpinella pruatjan Molk.) Ethanolic Extract on Male Albino Rat by Determined Hepatorenal Function Test and Histopathology Fitranto Arjadi; Dhadhang Wahyu Kurniawan; Yudhi Wibowo; Wahyu Siswandari; Lantip Rujito
Molekul Vol 14, No 2 (2019)
Publisher : Universitas Jenderal Soedirman

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (474.961 KB) | DOI: 10.20884/1.jm.2019.14.2.542

Abstract

Pimpinella pruatjan Molkis a local indegineuos plant speciescommonly used  aphrodisiac.This studywas performed to analyze the effect of acute administration of purwoceng (Pimpinella pruatjan Molk.) roots ethanol extract to liver and kidney histological damagein rats. The study used an experimental approachusing post test only with control group design. Rats were randomly divided into five groups; 3 rats in each group. Group A as a control group received aquadest, group B, C, D, and E were given purwoceng roots ethanol extract dose of 5 mg/kgBW, 50 mg/kgBW, 300 mg/kgBW, and 2000 mg/kgBW respectively.Liver histological damage was assessed by a modification of the Roenigk score, whereaskidney damage was by the semiquantitative scoring of proximal tubular necrosis. UV test was used to quantify the AST and ALT levels, the measurement of blood urea levels was using the Urease-GLDH method, and Jaffe methodwas used to access the creatinine levels.Kruskal-Wallis test showed that liver and kidney histologicalparameterswere not significantly affected, as well as theblood urea and creatinine levels (p>0.05).Meanwhile,ALT level wasonly parameters which showed the significant test (p <0.05)among groups. Study concluded that the liver and kidney histological appearance, AST, blood urea, and creatinine levels in the male albino rat were not significantly affected by acute administration of Purwoceng roots in various dosesbut  the ALT level was significantly affected
FORMULASI GEL ANTIOKSIDAN DARI EKSTRAK ETANOL BUNGA BROKOLI (Brassica oleracea L. var. italica) DENGAN MENGGUNAKAN METHOCEL K15M PREMIUM EP Eka Puspita; Teuku Nanda Saifullah Sulaeman; Dhadhang Wahyu Kurniawan
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 09 No. 01 April 2012
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pji.v9i1.690

Abstract

ABSTRACT Broccoli is one kind of plant variety compounds antioxidant unit that inhibited potentially damaging of body’s tissues and organ cause of over amount of free radical accumulation. New research in USA indicated that broccoli can help skin cell against the damaging effect caused of UV light radiation. This research used laboratorium experimental design, scoring technique and quantitative descriptive analysis. The purpose of this research is to explored that broccoli ethanol extract (Brasicca oleracea var Italica) could be formulated as an antioxidant gel by Metocel K15M Premium EP base, produced a good physical characteristic and still has an antioxidant activity. This research is done by extraction, extract characterisation, gel formulation by four variation of extract and evaluated the formulation of gel. Extraction is done by maseration with ethanol 70%, characterisation is done by organoleptic observation envelope in colour, smell, taste and form of extract. Gel formulation is made by four formulas of gel which is added by an ethanol extract of broccoli with different concentration. Evaluated gel is done by physical stability test and antioxidant activity test with DPPH methods. The result of this research indicated that gel formulation produced formula 1, formula 2, formula 3 and formula 4. The most optimal gel formulation was formula 2 which is detemined from physical stability aspect based on changes in physical appearance, colour, odor, pH and viscosity during 28 days storage periods. Antioxidant activity is determined by DPPH (1,1-Diphenyl-2-Picryl Hidrazyl) testing method. This test showed that IC50 of broccoli (Brasicca oleracea var Italica) ethanol extract is 12,479 mg/mL. Key words: Gel formulation, antioxidant, broccoli ethanol extract, Methocel K15M Premium EP.
Co-Authors Eka Puspita Fitranto Arjadi Lantip Rujito Teuku Nanda Saifullah Sulaeman Wahyu Siswandari Yudhi Wibowo