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Haeria Haeria
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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APLIKASI KIMIA KOMPUTASI DALAM HUBUNGAN STRUKTUR AKTIVITAS SENYAWA ANALOG TURUNAN QUINOLIN DARI Cinchona ledgeriana Moens SEBAGAI ANTIMALARIA Nur Syamsi Dhuha; Muhammad Aswad; Haeria Haeria
Jurnal Farmasi UIN Alauddin Makassar Vol 2 No 2 (2014): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v2i2.2199

Abstract

Study of QSAR explains quantitative relation between molecular structure and biological activity of molecule. QSAR analysis to the 16 analogues of quinoline compound as antimalarial agents had been done by using physicochemical properties like netto atom charge, total energy, binding energy, electronic energi, heat of formation, moment dipol, volume, hydration energi, log P, refractivity, polarisability, mass, HOMO energy, and LUMO energy as predictors. Calculation of the physicochemical properties was conducted with semiempirik AMI method, while the compound activity obtained from literature. Statistical analysis and the best valid equation based on statistical criteria of analytical regression and leave-one-out cross validation. The result showed that physicochemical properties of Quinoline Analogues which correlate to antimalarial activities are partial charge in several atoms and LUMO energy.
UJI AKTIVITAS PENGHAMBATAN FRAKSI NON POLAR EKSTRAK KLIKA ANAK DARA (Croton oblongusBURM F.) TERHADAP SEL KANKER HELA Nurshalati Tahar; Haeria Haeria; Hamdana Hamdana
Jurnal Farmasi UIN Alauddin Makassar Vol 3 No 3 (2015): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v3i3.2216

Abstract

Anak Dara (Croton oblongusBurm f.) merupakan tanaman asli Indonesia. Telah dilakukan penelitian Uji Aktivitas Penghambatan Fraksi Non Polar Ekstrak Klika Anak Dara (Croton oblongusBurm f.) terhadap Sel Kanker HeLa dengan tujuan untuk menentukan aktivitas penghambatan fraksi non polar ekstrak Klika Anak Dara (Croton oblongusBurm f.) terhadap sel kanker HeLa dengan metode MTT. Fraksi non polar ekstrak klika anak dara (Croton oblongus Burm f.)diperolehfraksi A, B dan C, dibuatdengankonsentasi 1000 ppm; 500 ppm; 250 ppm; 125 ppm; 62,5 ppm; 31,25 ppm; dan 15,625 ppm, sertadigunakankontrolseldankontrol MTT. SetiapfraksidiujikanterhadapselHeLadanditambahkan MTT untukmengetahuisel yang masihhidupdenganmengukurabsorbansinyapada ELISA Reader.Hasilanalisisprobitmenunjukkannilai IC50 fraksi A, B dan C yaitu218,776 µg/mL; 107,15 µg/mL; 281,838 µg/mL.Berdasarkanhasiltersebutdiketahuibahwafraksi non polar ekstrakKlikaAnak Dara (Croton oblongusBurm f.) memilikiaktivitaspenghambatanterhadapselkankerHeLapadakonsentrasitinggi, namuntidakdapatdigunakansebagaiobatantikanker.
Co-Authors Hamdana Hamdana Muhammad Aswad Nur Syamsi Dhuha Nurshalati Tahar