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All Journal Jurnal Ilmiah Farmasi Jurnal Kesehatan Journal of Pharmaceutical and Medicinal Sciences JURNAL FARMASI GALENIKA Jurnal Mandala Pharmacon Indonesia Jurnal Ilmiah Farmasi Farmasyifa ad-Dawaa : Journal of Pharmaceutical Sciences Jurnal farmasi UIN Alauddin Makassar Eureka Herba Indonesia JURNAL PENGABDIAN MASYARAKAT YAMASI Jurnal Farmasi Galenika Halal Science
Nur Syamsi Dhuha
Universitas Islam Negeri Alauddin Makassar
Religion Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health

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UJI EFEK IMUNOMODULATOR EKSTRAK DAUN KEMANGI (Ocimum basilicum. L) DENGAN PARAMETER AKTIVITAS DAN KAPASITAS FAGOSITOSIS SEL MAKROFAG PADA MENCIT (Mus musculus) JANTAN Haeria, Haeria; Dhuha, Nur Syamsi; Hasbi, Muhammad Ikram
JURNAL FARMASI GALENIKA Vol 4 No 1 (2017): Jurnal Farmasi Galenika Volume 4 No 1, 2017
Publisher : Sekolah Tinggi Farmasi Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (346.492 KB)

Abstract

Telah dilakukan penelitian tentang Uji Efek Imunomodulator Ekstrak  Daun Kemangi (Ocimum    Basilicum.  L)  dengan  Parameter   Aktivitas   dan   Kapasitas  Fagositosis Sel Makrofag Pada  Mencit   (mus musculus) Jantan. Penelitian ini bertujuan untuk mengetahui efek imunomodulator dari ekstrak daun kemangi (Ocimum basilicum. L) yang berdasarkan pada aktivitas dan kapasitas fagositosis sel makrofag dari mencit jantan dengan pemberian variasi dosis. Pada Kelompok I diberi control positif Imboost force® 0,795 mg/kg BB mencit dan kelompok II diberi Na CMC 1 %, Kelompok III, IV dan V masing-masing diberi perlakuan dengan memberikan dosis acuan ekstrak yang berbeda sebanyak 200 mg/kg BB, 400 mg/kg BB, dan 800 mg/kg BB. Proses perlakuan di berikan selama 7 hari dan  pada hari ke-8 mencit di induksi bakteri Stapylococcus aureus secara Intraperitoneal, lalu dibedah dan diambil cairan peritoneumnya. Selanjutnya diamati di bawah mikroskop dengan bantuan alat hemositometer. Berdasarkan analisis statistik aktivitas fagositosis sel makrofag, pada dosis 400 mg/kg BB dan 800 mg/kg BB tidak beda nyata atau dikatakan memiliki efek yang sama dengan kontrol positif Imboost Force. Sedangkan pada analisis statistik kapasitas fagositosis sel makrofag tidak berbeda nyata antara 3 variasi dosis dengan kontrol positif Imboost force.
Studi potensi ubi kelapa (Dioscorea alata. L) sebagai bahan penghancur tablet Haeria Doloking; Nur Syamsi Dhuha; Pratiwi Ningsi
Jurnal Ilmiah Farmasi Vol. 15 No. 1 (2019): Jurnal Ilmiah Farmasi
Publisher : Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/jif.vol15.iss1.art1

Abstract

IntisariLatar Belakang: Salah satu upaya untuk mewujudkan kemandirian produksi bahan baku farmasi Indonesia adalah dengan memanfaatkan pabrik sebagai sumber. Dioscorea alata L sebagai salah satu sumber pati perlu dipelajari untuk pengembangan potensial sebagai tablet disintegran.Tujuan: Tujuan penelitian ini adalah untuk mengetahui karakteristik pati Dioscorea alata L. dan mengetahui potensi sebagai bahan disintegran tablet.Metode: Analisis karakteristik meliputi proksimat, kandungan amilosa, morfologi granular, kristalinitas, kekuatan pengembangan, dan pengikatan kapasitas air. Studi potensial sebagai disintegran dilakukan dengan merumuskan tablet piroksikam menggunakan pati Dioscorea alata dibandingkan dengan pati jagung. Evaluasi sifat-sifat disintegran dilakukan dengan uji disintegrasi, uji kerapuhan, uji kekerasan, dan uji disolusi tablet.Hasil: Berdasarkan studi karakteristik pati Dioscorea alata L., kadar air, abu, protein, dan lemak masing-masing adalah 13,08%, 0,23%, 1,43%, dan 0,81%. Kemudian, Amilosa adalah 18,08%. Daya bengkak dan pengikatan kapasitas air menunjukkan 1,21 dan 3,31. Analisis morfologi granular menunjukkan bentuk ellipsoid dan bola. Kristal pati menunjukkan bentuk semikristal dengan pola kristal ortorombik. Uji disintegrasi tablet menunjukkan bahwa formula I dan II, memiliki waktu hancur 3,50 dan 4,25. Uji kelayakan formula I dan formula II adalah 0,011% dan 0,008%. Uji kekerasan Formula I dan Formula II menunjukkan 5kg dan 6kg. Uji disolusi Formula I dan Formula II menunjukkan 88,85% dan 85,58%.Kesimpulan: Dari hasil tersebut, pati Dioscorea alata L. berpotensi sebagai bahan penghancur tabletKata kunci: Dioscorea alata L., tablet, disintegrant, pati, bahan baku Potential Study of Ubi Kelapa (Dioscorea Alata. L) Starch as Tablet Desintegrant MaterialAbstract Background: One of the efforts to realize the sovereignty of Indonesia's pharmaceutical raw material production is to utilize the plant as a source. Dioscorea alata L as one of the starch sources needs to be studied for potential development as a tablet disintegrant.Objective: The aims of the research are to determine  the characteristic of Dioscorea alata L. starch and to find out the potential as tablet disintegrant material.Method: Characteristic analysis include are proximate, amylose content, granular morphology, crystallinity, swelling power, and water capacity binding. The potential study as disintegrant  was performed by formulating a piroxicam tablet using  Dioscorea alata starch compared to corn starch. Evaluation of the disintegrant properties was performed by disintegration test, friability test, hardness test, and dissolution test of the tablets.Results: Based on the characteristic study of Dioscorea alata L. starch, water, ash, protein, and fat contents are 13.08%, 0.23%, 1.43%, and 0.81%, respectively. Then, Amylose is 18.08%. Swelling power and water capacity binding  shows 1.21 and 3.31. Glanular morphology analysis shows ellipsoid and spherical form. The crystallinity of the starch shows as semicrystal form with orthorhombic crystal pattern. Tablet disintegration test shows that formula I and II, has disintegration time 3.50 and 4.25. Friability test of formula I and formula II is 0.011% and 0.008%. Hardness test of Formula I and Formula II shows 5kg and 6kg.  Dissolution test of Formula I and formula II shows 88.85% and 85.58%.Conclusion: Over the results, the Dioscorea alata L. starch has the potential as the tablet disintegrant materialKeywords: Dioscorea alata L., tablet, disintegrant, starch, raw material
STUDI AKTIVITAS INHIBITOR TIROSINASE DAN KADAR FENOLIK TOTAL EKSTRAK METANOL JAMUR TIRAM PUTIH (Pleurotus ostreatus) Nur Syamsi Dhuha; Nur Suci Suci Wahdaniya; Syamsuri Syakri
Jurnal Kesehatan THE 2nd ALAUDDIN PHARMACEUTICAL CONFERENCE AND EXPO (ALPHA-C) 2020
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i1.18166

Abstract

Oyster mushroom (Pleurotus ostreatus) contains vitamin B, vitamin C and carbohydrates such as β-glucans, monoterpenoids, triterpenoids, potential sources of lignin and phenols. The presence of phenolic compounds indicates the ability of oyster mushrooms as potential antioxidants and anti-tyrosinases. Searching for depigmentation agents in cosmetics is necessary to ensure safety and reduce side effects. The aims of this study are to determine the inhibitory activity of tyrosinase and total phenolic levels of Pleurotus ostreatus methanol extract. Tyrosinase inhibitor activity was measured using the Enzyme Linked Immunosorbent Assay (ELISA) method at 490 nm with various concentrations, which were 55 ppm, 65 ppm, 75 ppm, 85 ppm and 95 ppm. Determination of total phenolic levels at a concentration of 100 ppm using a UV-Vis Spectrophotometer at 744.8 nm. Based on the research, the percentage of tyrosinase inhibitor of Pleurotus ostreatus methanol extracts at concentrations of 55 ppm, 65 ppm, 75 ppm, 85 ppm and 95 ppm were 17.6%, 19.5%, 22.2%, 25.9%, and 35.7%, respectively. The result of the IC50 and total phenolic content are 9.06% and 1.13%. These results exhibit that the methanol extract of Pleurotus ostreatus has a very strong tyrosinase inhibitor power.
THE POTENTIAL OF SORGHUM BICOLOR L. AS A BLOOD GLUCOSE LOWERING AGENT : A REVIEW Dwi Wahyuni Leboe; Nur Syamsi Dhuha; Munifah Wahyuddin; Nur Rezky Rutami A
Jurnal Kesehatan THE 2nd ALAUDDIN PHARMACEUTICAL CONFERENCE AND EXPO (ALPHA-C) 2020
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/kesehatan.v1i1.18181

Abstract

The increasing mortality rate in Indonesia due to diabetes mellitus is a health problem in the world, especially in Indonesian. Evidenced by prevalence of diabetes mellitus which increases every year and is estimated in 2030 achieved 21,3 million according by WHO. Pharmacological therapy which cost is relatively expensive and can caused side effects from the use of chemical drugs. For this reason, the importance of finding new alternative therapy. Sorghum bicolor L. is a cereal that has high nutritional value and phytochemical compounds. This research purpose to know contain of Sorghum bicolor L. and the mechanisme   Sorghum bicolor L. as a blood glucose lowering agent. In this research is the literature study method based on primary and secondary data obtained. The database obtained is from Google scholar, Science direct, Research gate, NCBI, MDPI by using keywords. And the analysis of 43 journals obtained were scanned and analyzed in more detail by introduction, method, result, and conclusion of each journal . And the made in the data analysis table. Shows that Sorghum bicolor L. can be used as a blood glucose lowering agent because contain antidiabetic compounds, namely is phenolic compounds of phenolic acid, flavanoids, and tannin. And has a low glycemic index value and high fiber. Which can provide hypoglycemic effects and reduce postprandial blood glucose levels because it a slor digestion, slow gastric emptying, can inhibit the activity of digestive enzymes, namely the activity of α-glucosidase and  α- amylase, increasen insulin sensitivity, and inhibits the process of glucogenesis in the liverblood pressure, broken bones, diabetes, malaria, ulcers, vomiting blood, bleeding, appendicitis and lungs.
Aktivitas Inhibisi Pertumbuhan Plasmodium falciparum dan Micobacterium tuberculosis dari Ekstrak dan Partisi Klika Kayu Jawa (Lannea coromandelica [Houtt.] Merr.) Nursalam Hamzah; Nurhidayah Wahid; Muh Ihsan; Nur Syamsi Dhuha; Karnila Amir Tahir; Alifia Putri Febrianti; Isriany Ismail
Jurnal Farmasi dan Ilmu Pengobatan Vol 2 No 2 (2017): JPMS
Publisher : STIFA Makassar

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Abstract

Malaria and tuberculosis are two diseases with high prevalence in Indonesia. The treatment has a problem because some types of plasmodium and mycobacterium resistance with antituberculosis and antimalarials which are used today. To solve this problem, exploration to create a new drug must be done. Kayu jawa (Lannea coromandelica [Houtt.] Merr.) is one of the plants commonly used as a traditional medicine for curing malaria and tuberculosis. This research aimed to explore the antimalaria dan antituberculosis of L. Coromandelica. The procedure begins with the extraction of stem bark with methanol, then partitioned by solid-liquid extraction to found soluble and insoluble hexane partitions. Both extract and partitions were tested for anti-plasmodium activity by Desjardins method and antituberculosis by MODS method. The result showed that all samples can inhibit Mycobacterium tuberculosis growth and also Plasmodium falciparum. In conclusion, L. Coromandelica has a potential to developed as antimalaria and antituberculosis drug.
Acute Toxicity Ethanol Extract of Bidara Leaves (Ziziphus spina-christi L.) Against Liver and Kidney Function of White Rats Nur Syamsi Dhuha; Haeria; Hardyanti Eka Putri
Eureka Herba Indonesia Vol. 1 No. 1 (2020): Eureka Herba Indonesia
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/ehi.v1i1.3

Abstract

Bidara plants have the efficacy as antioxidants, anti-inflammatory, antimicrobial, anti- fungal and prevents tumours. Bidara is efficacious to protect human DNA cells caused by damage from actinic radiation. This study aims to explore the acute toxicity test of the ethanol extract of Bidara leaves using white mice as experimental animals. A total of 30 white rats (Rattus norvegicus) Wistar strain obtained from the Eureka Research Laboratory (Palembang, Indonesia) weighing between 200 - 250 grams. After one week of adaptation, the mice were randomly divided into the following six groups, each containing five animals: Normal control group and Bidara extract group (50mg/kg BW; 150 mg/kg BW; 450 mg/kg BW; 1350 mg/kg BW; and 4050 mg/kg BW). This study shows that the extract of Bidara leaves has a relatively high toxic dose, namely at a dose of 4050 mg/kg BW. Bidara leaf extract at doses below 1500 mg/kg BW, shows no toxic effect on the liver. In conclusion, bidara leaf extract has a toxic dose above 4000 mg/kg BW in Wistar white rats.
Potensi Pati Umbi Tire (Amorphopallus onchopyllus) Pregelatinasi Paut Silang Sebagai Bahan Tambahan Tablet Kempa Langsung Haeria Haeria Haeria; Nur Syamsi Dhuha; A Rahmi Azhariani
Jurnal Ilmiah Farmasi Farmasyifa Vol 1, No 1 (2018)
Publisher : Universitas Islam Bandung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29313/jiff.v1i1.3133

Abstract

Telah dilakukan penelitian karakterisasi pati umbi tire (Amorphopallus onchopyllus) pregelatinasi dan pati umbi tire pregelatinasi paut silang. Untuk memperoleh kualitas produk yang diinginkan, karakteristik pati umbi tire dapat dimodifikasi, metode modifikasi yang digunakan adalah cross-linking. Prinsip modifikasi ini yaitu mensubstitusi gugus fosfat dengan gugus hidroksil pada pati. Penelitian ini bertujuan untuk membandingkan karakteristik pati umbi tire yang mengalami modifikasi secara cross-linking terhadap pati yang tidak dimodifikasi. Untuk mencapai tujuan, penelitian ini melalui 3 tahapan : (1) Tahap karakterisasi pati umbi tire, (2) Tahap modifikasi pati umbi tire dengan metode cross-linking untuk merubah sifat pati umbi tire sesuai dengan spesifikasi yang memenuhi syarat sebagai bahan tambahan sediaan farmasi, (3) Tahap uji karakterisasi pati umbi tire yang telah dimodifikasi berdasarkan uji organoleptik, uji homogenitas, uji pH dan uji viskositas. Pati pregelatinasi dibuat dengan pemanasan di atas suhu gelatinasi pati, kemudian difosfolirasi dengan mereaksikan pati pregelatinasi dengan Na2HPO4. Hasil penelitian menunjukkan karakteristik dari pati umbi tire yang mengalami modifikasi cross-linking lebih baik dibandingkan dengan pati umbi tire yang tidak mengalami modifikasi dan pati umbi tire pregelatinasi paut silang dapat dijadikan sebagai bahan tambahan tablet kempa langsung.
APLIKASI KIMIA KOMPUTASI DALAM HUBUNGAN STRUKTUR AKTIVITAS SENYAWA ANALOG TURUNAN QUINOLIN DARI Cinchona ledgeriana Moens SEBAGAI ANTIMALARIA Nur Syamsi Dhuha; Muhammad Aswad; Haeria Haeria
Jurnal Farmasi UIN Alauddin Makassar Vol 2 No 2 (2014): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v2i2.2199

Abstract

Study of QSAR explains quantitative relation between molecular structure and biological activity of molecule. QSAR analysis to the 16 analogues of quinoline compound as antimalarial agents had been done by using physicochemical properties like netto atom charge, total energy, binding energy, electronic energi, heat of formation, moment dipol, volume, hydration energi, log P, refractivity, polarisability, mass, HOMO energy, and LUMO energy as predictors. Calculation of the physicochemical properties was conducted with semiempirik AMI method, while the compound activity obtained from literature. Statistical analysis and the best valid equation based on statistical criteria of analytical regression and leave-one-out cross validation. The result showed that physicochemical properties of Quinoline Analogues which correlate to antimalarial activities are partial charge in several atoms and LUMO energy.
STUDI INSILICOHUBUNGAN KUANTITATIF STRUKTUR-AKTIVITAS (HKSA)SENYAWA TURUNAN BENZIMIDAZOLE, DOCKING MOLEKUL, PENELUSURAN FARMAKOFOR, VIRTUAL SCREENING, UJI TOKSISITAS, PROFIL FARMAKOKINETIK SEBAGAI ANTI-TUBERKULOSIS Nursalam Hamzah; Nur Syamsi Dhuha; Reza Ramadhan
Jurnal Farmasi UIN Alauddin Makassar Vol 3 No 3 (2015): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v3i3.2215

Abstract

Telah dilakukan Telah dilakukan penelitian studi hubungan kuantitatif struktur-aktivitas (HKSA), docking molekul, penelusuran farmakofor, virtual screening, uji toksisitas, dan profil farmakokinetik pada turunan Benzimidazole sebagai inhibitor DNA Gyrase pada penyakit Tuberkulosis secara in silico. Penelitian ini bertujuan untuk menemukan model persamaan HKSA senyawa, menemukan fitur-fitur farmakofor senyawa yang  bertanggung jawab atas aktivitas dan selektivitas DNA Gyrase, serta memilih senyawa hasil virtual screening yang kemudian ditentukan profil farmakokinetik, toksisitas, dan toksisitas metabolit untuk pengobatan Tuberkulosis. Prosedur dimulai dengan pemodelan dan optimasi geometri struktur molekul pada perangkat lunak HyperChem 8.0. Optimasi geometri dilakukan dengan metode Ab initio. Perhitungan Deskriptor HKSA, penentuan fitur farmakofor dan docking molekul dilakukan  dengan menggunakan perangkat lunak MOE 2009. Selanjutnya pengujian toksisitas dengan perangkat lunak Toxtree dan AdmetSAR, serta penentuan profil farmakokinetik dengan menggunakan program berbasis web PreADME dilakukan untuk 150.000 senyawa natural product dari zinc database. Dari penelitian didapatkan persamaan: Log 1/MIC = -8.6816 + 1.6938 AM1_LUMO + 0.0160 ASA_H – 3.9194 mr  + 0.1087 VSA, dimana r2 = 0,955 dan q2 = 0,8761, selanjutnya diperoleh hasil docking molekul pada protein kode 2XCS, senyawa 23 menunjukkan nilai docking score (S) -190.9309. Hasil virtual screening pada zinc database diperoleh senyawa dengan kode ZINC08964902 adalah senyawa yang paling baik diantara 150.000 senyawa yang dilihat dari sisi kecocokan pada query farmakofor, docking dengan metode farmakofor, prediksi bioavailabilitas menggunakan rule of 5 Lipinski, dan prediksi ADME/T
DETERMINATION OF ETHANOL EXTRACT SUNSCREEN POTENTIAL OF RAMBUTAN RIND (Nephelium lappaceum L.) Surya Ningsi; Nur Syamsi Dhuha; UL Miftahurrahmah
Jurnal Farmasi UIN Alauddin Makassar Vol 3 No 4 (2015): Jurnal Farmasi
Publisher : Universitas Islam Negeri Alauddin Makassar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24252/jurfar.v3i4.2260

Abstract

A sunscreen research to Determine the potential of rambutan rind (Nephelium lappaceum L.) ethanol extract has been conducted. This study aims to Determine the SPF value, percent transmission of erythema (% Te), and percent transmission of pigmentation (% Tp) of rambutan rind (Nephelium lappaceum L.) ethanol extract by using UV-VIS spectrophotometer.Sunscreen potential determination of rambutan rind extract is done based on the SPF value measured at a wavelength of 290-400 nm, the calculation method% of% Te and Tp at a wavelength 292.5 to 372.5 nm at concentration 10, 20, 40, 80, and 160 ppm by using a UV-VIS spectrophotometer.The results Showed that the SPF value of the extract at concentration of 10 ppm, 20 ppm, 40 ppm, 80 ppm, and 160 ppm respectively were 1.12; 1.23; 1.56; 2,37; and 5.32.The value of% Te at concentration of 10 ppm, 20 ppm, 40 ppm, 80 ppm, and 160 ppm respectively were 77.21; 62.87; 38.86; 16.18 and 3.10. The value of% Tp at concentration of 10 ppm, 20 ppm, 40 ppm, 80 ppm, and 160 ppm respectively were 88.01; 81.62; 68.41; 49.65 and 25.16. Obtained from the values, rambutan rind extract at concentration of 80 ppm has an SPF value of 2:37 the which means it has the potential for a minimum of sunscreen protection while at a concentration of 160 ppm, it has an SPF value of 5:32 the which means it has the potential of middle sunscreen protection. Rambutan rind extract at concentration of 80 ppm has a potential to protect against UV rays in suntan category with the value of percent tranmission erythema (% Te) by 16.18 and percent transmission of pigmentation (% Tp) by 49.65. At concentration of 160 ppm, it has a potential to protect against UV rays in extra protection category with the value of percent tranmission erythema (% Te) by 36.18 and percent transmission of pigmentation (% Tp) by 25.16 roomates includes in total blocks category.
Co-Authors A Rahmi Azhariani Afrisusnawati Rauf Alfiana Dwi Puspita Alifia Putri Febrianti Doloking, Haeria Dwi Wahyuni Leboe Fatima Abdurrahman Gemy Nastity Handayany Haeria Haeria Haeria Haeria Haeria Haeria Haeria Haeria Haeria Haeria Haeria Haeria Haeria Hardiyanti Eka Putri Hardiyanti Syarif Hardyanti Eka Putri Hasbi, Muhammad Ikram Hasma Nur Putrianti Isriany Ismail Jumasni Adnan Karnila Amir Tahir Khaerani Khaerani, Khaerani Leboe, Dwi Wahyuni Leboe, Dwi Wayuni Muh Ihsan Muhammad Aswad Muhammad Ikram Hasbi Nonci, Faridha Yenny Nur Rezky Rutami A Nur Suci Suci Wahdaniya Nurfadilah Absa Nurhidayah Wahid Nursalam Hamzah Nursalam Hamzah Nurshalati Tahar Pratiwi Ningsi Putri Juanti Reza Ramadhan St Rahmah Akbar Surya Ningsi Syamsuri Syakri UL Miftahurrahmah Wa Sinta Wahyuddin, Munifah Wulandari, Leli