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All Journal INDONESIAN JOURNAL OF PHARMACY Jurnal Kimia Terapan Indonesia
Riris Istighfari Jenie
Fakultas Farmasi, UGM, Sekip Utara Yogyakarta 55281
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Materials Science & Nanotechnology Medicine & Pharmacology

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SYNTHESIS AND CYTOTOXIC ACTIVITY OF 2,5-BIS(4-BORONIC ACID)BENZYLIDINE CYCLOPENTANONE ON HER2 OVEREXPRESSED-CANCER CELLS Rohmad Yudi Utomo; Herwandhani Putri; Pudjono Pudjono; Ratna Asmah Susidarti; Riris Istighfari Jenie; Edy Meiyanto
Indonesian Journal of Pharmacy Vol 28 No 2, 2017
Publisher : Faculty of Pharmacy Universitas Gadjah Mada, Yogyakarta, Skip Utara, 55281, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (949.546 KB) | DOI: 10.14499/indonesianjpharm28iss2pp74

Abstract

Development of chemotherapeutic agent and boron carrying pharmaceutical based on HER2 specific targeted is important due to its role in enhancing cancer progression. The purpose of this study is to synthesize curcumin analogue, namely Pentagamaboron-0 (PGB-0) or 2,5-bis(4-boronic acid)benzylidine cyclopentanone, and to explore the cytotoxic activity on HER2 overexpressed-cancer cells. MCF-7/HER2 was used as a model of HER2 overexpressed-cancer cells and NIH3T3 as normal cells. PGB-0 bound to ATP binding site of HER2 and EGFR based on molecular docking study. PGB-0 was synthesized resulting in 33% yield and was confirmed by IR, 1HNMR, 13CNMR and Mass spectroscopy. Based on MTT assay PGB-0 decreased cells viability on MCF-7/HER2 cells with IC50 value of 270 µM but performed no effect on NIH3T3 cells. Cell cycle analysis revealed that PGB-0 increased sub-G1 accumulation. PGB-0 decreased HER2 expression in a dose-dependent manner. We conclude that the new compound PGB-0 inhibits cell growth through cell death induction and decreased HER2 expression. Thus, PGB-0 is potential to be developed as a chemotherapeutic agent and boron carrying pharmaceutical targeted on the HER2 receptor.
TOKSISITAS AKUT EKSTRAK ETANOLIK BIJI BUAH PINANG (Areca catechu L.) TERHADAP TIKUS JANTAN GALUR SPRAGUE DAWLEY Sri Handayani; Edy Meiyanto; Riris Istighfari Jenie; Ratna Asmah Susidarti
Jurnal Kimia Terapan Indonesia Vol 14, No 2 (2012)
Publisher : Research Center for Chemistry - LIPI

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (548.977 KB) | DOI: 10.14203/jkti.v14i2.338

Abstract

Ekstrak etanolik biji buah pinang (Areca catechu L.) memperlihatkan aktivitas penghambatan proliferasi selkanker payudara T47D dan MCF-7. Tikus (Rattus norvegicus) jantan galur Sprague Dawley usia 8 minggu dibagidalam lima kelompok, yaitu empat kelompok perlakuan dan satu kelompok kontrol pelarut CMC-Na 5%. Pemejanandosis tunggal peroral dilakukan terhadap subjek uji dengan variasi dosis ekstrak etanolik biji pinang mulai dari dosisyang paling aman hingga dosis tertinggi yang diharapkan toksik pada semua hewan uji (0,1; 0,72; 5,36 dan 10gram/kg berat badan).  Pengamatan dilakukan selama 24 jam terhadap gejala-gejala toksik, wujud dan mekanismeefek  toksik  maupun  patologi  organ  vital.  Pengamatan  mikroskopis  berupa  histopatologi  beberapa  organ  vitaldilakukan dengan pengecatan Hematoxillen&Eosin (H&E). Hasil uji menunjukan bahwa semua kelompok dosisperlakuan tidak mengalami gejala toksik, sama halnya dengan kelompok kontrol. Pemberian dosis tunggal ekstraketanolik biji pinang tidak menimbulkan kematian pada subjek uji, bahkan pada dosis tertinggi sekalipun. Oleh karenaitu  pengamatan  dilanjutkan  hingga  14  hari.  Pada  hari  ke-15  dilakukan  pembedahan  pada  semua  subjek  uji.Pengamatan  mikroskopis  menunjukkan  tidak  ada  perubahan  histopatologis  yang  berarti  pada  seluruh  kelompokperlakuan. Hasil uji ini menambah dasar keamanan penggunaan ekstrak etanolik biji pinang dalam pengembangannyasebagai agen terapi alternatif.  Kata kunci:  Ekstrak etanolik,  Areca catechu, toksisitas akut, tikus
Co-Authors Edy Meiyanto Herwandhani Putri Pudjono Pudjono Ratna Asmah Susidarti Rohmad Yudi Utomo Sri . Handayani