Tirta Darmawan Susanto
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EFEK ANTIBAKTERI VIRGIN COCONUT OIL TERHADAP METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS Tirta Darmawan Susanto; Muchtan Sujatno; Hendro Sudjono Yuwono
Medicinus Vol 4, No 8 (2015): February 2015 - May 2015
Publisher : Fakultas Kedokteran Universitas Pelita Harapan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19166/med.v4i8.1186

Abstract

Kejadian infeksi, baik di lingkungan rumah sakit yang disebut infeksi nosokomial maupun di luar rumah sakit, cukup besar. Infeksi mempertinggi angka kematian dan kesakitan, serta memperlama waktu perawatan di rumah sakit. Saat ini banyak tanaman yang terbukti secara empiris memiliki efek antibakteri, diantaranya adalah minyak kelapa murni (Virgin Coconut Oil / VCO), oleh karena itu perlu dilakukan penelitian ini guna mengetahui efek anti bakteri VCO pada luka yang telah diinfeksi dengan Methicillin Resistant Staphylococcus aureus (MRSA).Telah dilakukan penelitian eksperimental laboratorium dengan desain penelitian Rancangan Acak Lengkap. Hewan coba yang digunakan adalah marmut jantan galur albino sebanyak 15 ekor . Dermis hewan coba diinsisi hingga diperoleh luka berukuran 9cm2 dasar otot, luka diinfeksi dengan suspensi bakteri MRSA, kemudian diberi 3 macam perlakuan yaitu dibiarkan saja tanpa pengobatan untuk control negatif, terapi VCO per oral 3 cc / hari dan terapi VCO topikal 0,4 cc / hari. Data yang diperoleh dianalisis dengan analysis of variance (ANOVA) dan two sample – T test.Hasil penelitian menunjukkan bahwa pemberian VCO topikal dengan dosis 0,4 cc / hari mampu mengobati infeksi dan mempercepat penyembuhan luka hewan coba secara bermakna (p = 0,043 < α = 0,05), tetapi pemberian VCO peroral 3 cc / hari menunjukkan hasil yang tidak bermakna (p = 0,376 > α = 0,05). Pemberian VCO per oral 3 cc / hari dan topikal 0,4 cc / hari mampu menurunkan jumlah lekosit darah pada hewan coba. Pemberian VCO topikal 0,4 cc / hari mampu membunuh bakteri sehingga dapat mengurangi jumlah bakteri pada luka secara bermakna (p = 0,0092 < α = 0,05), namun pemberian VCO per oral tidak mampu mengurangi jumlah bakteri pada luka secara bermakna (p = 0,17 > α = 0,05). Pada hasil penelitian di atas, dapat disimpulkan bahwa pemberian VCO topikal menunjukkan efek antibakteri yang bermakna untuk mengatasiinfeksi MRSA.
Risiko Terjadinya Adiksi Internet pada Remaja dengan Gangguan Pemusatan Perhatian dan Hiperaktivitas: Sebuah Laporan Kasus Berbasis Bukti Dewanto Andoko; Darien Alfa Cipta; Tirta Darmawan Susanto
Medula Vol 13 No 6 (2023): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v13i6.833

Abstract

Attention Deficit Hyperactivity Disorder (ADHD) constitutes a prominent neurodevelopmental disorder frequently observed in childhood, characterized by three core symptoms encompassing inattention, hyperactivity, and impulsivity. Notably, the persistence of ADHD can extend from childhood into adolescence and even adulthood. Importantly, it has been noted that in nearly half of cases where ADHD endures beyond childhood and into the later stages of life, there is a substantial elevation in the risk of various addictive behaviors, encompassing alcohol, nicotine, other substances, and behavioral addictions like internet addiction, in comparison to individuals without a history of ADHD. Against this backdrop, the present literature exploration is specifically focused on discerning the influence of childhood ADHD on the propensity for internet addiction in adolescence and young adulthood. To comprehensively address this query, a meticulously structured search was conducted across several renowned databases including Pubmed, EBSCOhost, Scopus, and ProQuest. The search parameters were thoughtfully adapted and refined to align seamlessly with the clinical question, ensuring the retrieval of pertinent and valuable information. Among the amassed results, one article was identified as particularly pertinent, serving as a concise compilation of the most recent insights into the intricate interplay between ADHD and internet addiction. The outcomes derived from this thorough meta-analytical review not only establish a substantial association between childhood and adolescent ADHD and an augmented susceptibility to internet addiction in later years but also provide quantification through a notable Crude Odds Ratio (COR) of 3.76 (95% CI: 2.75, 5.15) and an Adjusted Odds Ratio (AOR) of 2.51 (95% CI: 2.09, 3.02) following meticulous confounder adjustments. Furthermore, a striking observation emerges wherein adolescents grappling with internet addiction manifest intensified ADHD symptoms, corroborated by evident elevation in Abbreviated Conners Rating Scale scores relative to their non-addicted counterparts. Collectively, these findings underscore the imperative of recognizing and addressing the heightened risk of internet addiction among adolescents with a history of ADHD and spotlight the pressing need for nuanced interventions and comprehensive support strategies.