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Factors Influencing the Success Rate of Cardiopulmonary Resuscitation Hanif, Aisyah Amanda; Rachman, Iwan Abdul; Yuwono, Hendro Sudjono
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Althea Medical Journal

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Background: Cardiopulmonary resuscitation (CPR) is a series of actions performed on cardiac arrestÂ patients. Not all patients receiving CPR can survive. The outcome of CPR is influenced by several factors.Â This study was conducted to determine the success rate of CPR and the factors influencing it in Dr. HasanÂ Sadikin General Hospital in 2013.Methods: This study was conducted by using 168 patient medical records who underwent CPR and met theÂ inclusion criteria in the Resuscitation Room of Dr. Hasan Sadikin General Hospital from January to DecemberÂ 2013. The collected data consisted of age, gender, pre-arrest diagnosis, initial rhythm, response time andÂ clinical outcome of CPR. The results were expressed in frequencies and percentage. The data were analyzedÂ using the chi-square test.Results: The Success rate of CPR was 15.5%. The success rate was higher in patients with cardiac prearrestÂ diagnoses (8.33%, p=0.024). The most common initial rhythm was unshockable rhythms (83.92%),Â yet patients with shockable heart rhythms had higher success rates (40.74%, p<0.001). All of the survivingÂ patients had response time within the first minute from cardiac arrest.Conclusions: Success rate of CPR in the resuscitation room of Dr. Hasan Sadikin General Hospital duringÂ 2013 is still low. The factors influencing the survival rate are the pre-arrest diagnosis and initial heartrhythm. [AMJ.2015;2(4):615â9]Â DOI:Â 10.15850/amj.v2n4.657

Antidiabetic Activity of Calcium Bentonite in Alloxan Monohydrate-induced Diabetic Wistar Rat Models Alviana, Galuh; Yuwono, Hendro Sudjono; Sylviana, Nova
Althea Medical Journal Vol 2, No 3 (2015)
Publisher : Althea Medical Journal

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Background: Calcium bentonite is a natural clay that has the ability to absorb toxins and metabolite excess substances and often referred to as healing clay because it is used traditionally. This study aimed to determine the ability of local calcium bentonite to absorp high blood glucose..Methods: This study was an experimental study using 20 female Wistar rats and divided into two groups consisting of Group I (control group, n=10) and Group II (calcium bentonite group, n=10). Diabetes in rats was induced by alloxan monohydrate 150 mg/kg body weight intraperitoneally. Examination of blood glucose was performed three times; in the beginning of study, 72 hours after alloxan monohydrate induction, and four days after the given interventions. Blood glucose levels in mean values were analyzed using t-independent test. Statistically significance was considered when p<0.05.Results: Oral calcium bentonite of 1g/kg body weight significantly lowered blood glucose level relatively to the control group with average value of 131.30 mg/dl (p=0.01).Conclusions: Calcium bentonite significantly lowers blood glucose levels.Â DOI:Â 10.15850/amj.v2n3.562

Effects of Calcium Bentonite on High Blood Cholesterol Level Yuwono, Hendro Sudjono; Tangke, Fadhli Rajif; Farenia, Reni
Althea Medical Journal Vol 5, No 3 (2018)
Publisher : Althea Medical Journal

Background: Calcium bentonite has been known to decrease high blood cholesterol level. This study aimed to explore whether a local calcium bentonite from West Java, Indonesia, had effect on lowering total blood cholesterol level.Methods: A laboratory experimental study was carried out on thirty adult male Wistar rats’ at Laboratory animals, Department of Pharmacology and Therapy, Universitas Padjadjaran in 2012. The rats were divided into five groups with six rats in each group, consisting of group I (negative control) with standard diet and distilled water, group II (positive control) with high lipid diet and distilled water, group III with high lipid diet and ezetimibe 0.18 g/rat/day, groups IV with high lipid diet and calcium bentonite 0.25 g/rat/day, group V with high lipid diet and calcium bentonite 0.5 g/rat/day. Ezetimibe as was used as this was an inhibitory agent of intestinal cholesterol absorption. Blood cholesterol levels were measured and analyzed using analysis of variance and Tukey’s post-hoc test.Results: Oral calcium bentonite at 0.25 g/rat/day and 0.5 g/rat/day significantly decrease total blood cholesterol level relative to the positive control group, 31.68% (p=0.018) and 32.87% (p=0.006) respectively, but its effect is inferior to ezetimibe 62.83% (p=0.000).Conclusions: Local calcium bentonite from West Java, Indonesia, has a significant lowering effect, however, the effect is less comparing to ezetimibe.

The Effect of Additional Magnesium Sulphate 80 mg with 0,5% Hiperbaric Bupivacaine to Onset and Duration of Action of Sensory and Motor Block Spinal Anaesthesia for Caesarean Section , Suwarman; Purwaningsih, Sriwahyuniati; Nawawi, A. Muthalib; Yuwono, Hendro Sudjono
Majalah Anestesia dan Critical Care Vol 33 No 3 (2015): Oktober
Publisher : Perdatin Pusat

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Addition of adjuvants to 0.5% hyperbaric bupivacaine for spinal anaesthesia performed to accelerate sensory and motor onset, minimal side effect of hemodynamics and prolongation analgesia. The aim of the study was to investigate the effect of additional 80 mg of magnesium sulphate 40% intratecal to 0.5% hyperbaric bupivacaine on onset and duration of sensory and motor block for cesarean section. The study was randomized double blind controlled study to 40 patients with American Society of Anesthesiology (ASA) physical status II whom underwent caesarean section in Dr. Hasan Sadikin General Hospital Bandung from April till May 2015. The additional 80 mg of 40% magnesium sulphate to 0.5% hyperbaric bupivacaine intratecal resulted earlier onset of sensory and motor block than group 0,9% sodium chloride (p˂0,001). The duration of sensory and motor block was longer in magnesium group than sodium chloride 0,9% group (p˂0,001). The study concluded that spinal anesthesia using 0.5% hyperbaric bupivacaine with magnesium sulphate produce faster onset and prolonged duration of sensory and motor blockade compared to 0.5% hyperbaric bupivacaine in cesarean section.

Incidence of Post Dural Puncture Headache (PDPH) after Spinal Anesthesia at Dr. Hasan Sadikin General Hospital Bandung in February–April 2015 Period , Suwarman; Sitanggang, Rully H.; Mayasari, Ferra; Yuwono, Hendro Sudjono
Majalah Anestesia dan Critical Care Vol 33 No 2 (2015): Juni
Publisher : Perdatin Pusat

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Post dural puncture headache (PDPH) occurs because of the cerebrospinal fluid leakage caused by dural puncture. Post dural puncture headache is a common complication after spinal anesthesia which incapacitating the patients. The purpose of our study is to describe the incidence of PDPH in patient undergone surgery with spinal anesthesia at Dr Hasan Sadikin General Hospital Bandung and obtaining the risk factor characteristics which associated with PDPH. This cross sectional observational study carried out 156 postoperative subjects with spinal anesthesia patients over February until April 2015. There were 10 subjects (6,41%) developed PDPH. The characteristics which assosciated with PDPH dan statistically significant (p value<0,05) are median and paramedian punctures technique (PR=19,722; CI 95% 6,377; 60,996), history of PDPH (PR=17,222; CI 95% 9,235; 32,469), and multiple punctures (PR=6,400; CI 95% 1,406; 29,132). Whereas, characteristic which associated independently with PDPH is the median and paramedian punctures technique (POR=29,121 CI 95% 33,842;220,745). Anesthesiologist have an important role to prevent PDPH with selection of spinal needle, selection of mastered technique, and improving anesthesiologist’s skill.

CEMENTO-OSSIFYING FIBROMA ON THE ANTERIOR MANDIBLE REGION: FIBROMA CEMENTO-OSSIFYING PADA REGIO DEPAN RAHANG BAWAH Isnandar; Kasman Manullang; Hendro Sudjono Yuwono
Dentika: Dental Journal Vol. 16 No. 1 (2011): Dentika Dental Journal
Publisher : TALENTA

Cemento-ossifying fibroma (COF) is a rare benign tumor which mostly affects the mandible and the most common site is in the premolar-molar region . It is a painless, generally slow-growing, benign lesion which enlarges in an expansive manner. It is usually detected in the third and fourth decade of life and is more common in women. Radiographically, they appear as well-defined unilocular or multilocular intraosseous mass in the premolar- molar region of the mandible. The lesion is invariably encapsulated and with mixed radiolucent density. Its histopathology shows fibrous tissues with calcified structures resembling bone or cementum. This article reports a rare case of a-20-year old male with history of swelling in the anterior mandible region at tooth region 33-43 causing difficulty in occlusion. We have performed marginal resection and put AO plate crossing the bone defect. There was no wound dehiscence and exposed AO plate after six months of close observation. In conclusion, the mass has been succesfully excised and reconstructed using AOplate. Patient has been referred to the prosthodontic department for having a denture.

Factors Influencing the Success Rate of Cardiopulmonary Resuscitation Aisyah Amanda Hanif; Iwan Abdul Rachman; Hendro Sudjono Yuwono
Althea Medical Journal Vol 2, No 4 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (553.013 KB)

Background: Cardiopulmonary resuscitation (CPR) is a series of actions performed on cardiac arrest patients. Not all patients receiving CPR can survive. The outcome of CPR is influenced by several factors. This study was conducted to determine the success rate of CPR and the factors influencing it in Dr. Hasan Sadikin General Hospital in 2013.Methods: This study was conducted by using 168 patient medical records who underwent CPR and met the inclusion criteria in the Resuscitation Room of Dr. Hasan Sadikin General Hospital from January to December 2013. The collected data consisted of age, gender, pre-arrest diagnosis, initial rhythm, response time and clinical outcome of CPR. The results were expressed in frequencies and percentage. The data were analyzed using the chi-square test.Results: The Success rate of CPR was 15.5%. The success rate was higher in patients with cardiac prearrest diagnoses (8.33%, p=0.024). The most common initial rhythm was unshockable rhythms (83.92%), yet patients with shockable heart rhythms had higher success rates (40.74%, p<0.001). All of the surviving patients had response time within the first minute from cardiac arrest.Conclusions: Success rate of CPR in the resuscitation room of Dr. Hasan Sadikin General Hospital during 2013 is still low. The factors influencing the survival rate are the pre-arrest diagnosis and initial heartrhythm. [AMJ.2015;2(4):615–9] DOI: 10.15850/amj.v2n4.657

Antidiabetic Activity of Calcium Bentonite in Alloxan Monohydrate-induced Diabetic Wistar Rat Models Galuh Alviana; Hendro Sudjono Yuwono; Nova Sylviana
Althea Medical Journal Vol 2, No 3 (2015)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (152.583 KB)

Background: Calcium bentonite is a natural clay that has the ability to absorb toxins and metabolite excess substances and often referred to as healing clay because it is used traditionally. This study aimed to determine the ability of local calcium bentonite to absorp high blood glucose..Methods: This study was an experimental study using 20 female Wistar rats and divided into two groups consisting of Group I (control group, n=10) and Group II (calcium bentonite group, n=10). Diabetes in rats was induced by alloxan monohydrate 150 mg/kg body weight intraperitoneally. Examination of blood glucose was performed three times; in the beginning of study, 72 hours after alloxan monohydrate induction, and four days after the given interventions. Blood glucose levels in mean values were analyzed using t-independent test. Statistically significance was considered when p<0.05.Results: Oral calcium bentonite of 1g/kg body weight significantly lowered blood glucose level relatively to the control group with average value of 131.30 mg/dl (p=0.01).Conclusions: Calcium bentonite significantly lowers blood glucose levels. DOI: 10.15850/amj.v2n3.562

Lethal Dose of Calcium Bentonite in Wistar Rats Dwika Audiyananda; Hendro Sudjono Yuwono; Adria Adnan
Althea Medical Journal Vol 8, No 2 (2021)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v8n2.2227

Background: Calcium bentonite is a type of clay produced by a devitrification of volcanic ash which is often used as a traditional medicine to absorb toxins and waste products of metabolism. The aim of this study was to determine the lethal dose of calcium bentonite in Wistar rats to explore its toxicity level and safe use.Methods: Fifty male and female Wistar rats were randomly divided into five groups for each sex. The control group was given 5 cc aquadest whereas the other four groups received calcium bentonite solution of 50 mg/kgBW, 300 mg/kgBW, 2,000 mg/kgBW, and 5,000 mg/kgBW, respectively, at a single dose. The weight was observed for up to 7 days and analyzed using the unpaired t-test and Mann-Whitney test. The death rate was calculated using the probit analysis. Median lethal dose results were then classified according to Loomis Criteria. Results: No deaths occurred at the highest dose, suggesting that the median lethal dose value of calcium bentonite was >5,000 mg/kgBW. No weight loss occurred due to the administration of calcium bentonite and a significant increase in the body weight was even observed in the male rat group. Interestingly, a significant decrease was found in the female rats group when compared to the control group.Conclusions: Calcium bentonite is classified as a practically non-toxic material with a median lethal dose of over 5,000 mg/kgBW.

PENGARUH BENTONIT PER ORAL TERHADAP PENURUNAN KADAR GLUKOSA DARAH TIKUS MODEL DIABETES MELITUS YANG DIINDUKSI ALOKSAN MONOHIDRAT Galuh Alviana; Hendro Sudjono Yuwono; Nova Sylviana
JURNAL ILMU FAAL OLAHRAGA INDONESIA Vol 3, No 2 (2020)
Publisher : PAIFORI

In Indonesia, it is estimated that there would be increasing in number of diabetes mellitus patients become 12 million cases in 2030. The expensive cost of conventional medications motivates people to find alternative medication. Bentonite is a natural clay which is a good absorbent and frequently called as healing clay for its potency in body detoxification. This study is an experimental research to prove bentonite which is a good absorbent and adsorbent in decreasing blood glucose concentration in diabetes mellitus. Subject of this research is 20 female Wistar rats which weigh 150–250 g. These subjects were divided into two groups: control group and bentonite group. Diabetes is induced by alloxan monohydrate 150mg/kg intraperitoneally, causing β cell necrosis in pancreas. Result of independent t-test showed that bentonite could significantly lower blood glucose levels with average value of 131.30 mg/dL (p=0.010). This concludes that bentonite canreduce blood glucose level in diabetic-induced rats.

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