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All Journal Journal of Dentomaxillofacial Science
Juni J. Nugroho
Department of Conservative Dentistry and Endodontics, Faculty of Dentistry, Hasanuddin University, Makassar, Indonesia
Dentistry

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Effect of pup out® on caspase 3 and interleukin-1B expression in pulp teeth: a paste contained jatropha, sidaguri, and melittin Maria Tanumiharja; Arfina S. Hamid; Aries C. Trilaksana; Christine A. Rovani; Nurhayati Natsir; Juni J. Nugroho; Indrya K. Mattulada; Lukman Muslimin
Journal of Dentomaxillofacial Science Vol. 6 No. 2 (2021): (Available online: 1 August 2021)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15562/jdmfs.v6i2.1232

Abstract

Objective: To examine the expression of caspase-3 and IL-1? following application of Pulp Out® on rabbit’s pulp teeth as well as histopathology.Material and Methods: The study was conducted on the maxillary incisors rabbits. The teeth were prepared and Pulp Out® was inserted at the base of prepared cavity, then restored with RM-GIC. After 24 hours, the animals were then euthanized and processed for histopathology and immunohistochemistry evaluation.Results: Our results indicated that Pulp Out®, when administered to the pulp teeth, increased the number and diameter of blood vessels. The expression of caspase-3 and IL-1? showed similarities to the expression of commercial devitalizing agent.Conclusion: Our results revealed that Pulp Out® is a valuable devitalization agent that should be further explored for its safety before clinical application.
Co-Authors Arfina S. Hamid Aries C. Trilaksana Christine A. Rovani Indrya K. Mattulada Maria Tanumiharja Nurhayati Natsir