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All Journal Althea Medical Journal Indonesian Journal of Biotechnology
Ina Rosalina
Universitas Padjadjaran
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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The Efficacy of Fucoidan on Gastric Ulcer Juffrie, Mohammad; Rosalina, Ina; Damayanti, Wahyu; Djumhana, Ali; A, Ariani; Ahmad, Harjono
Indonesian Journal of Biotechnology Vol 11, No 2 (2006)
Publisher : Universitas Gadjah Mada

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Abstract

Hyperacidity causes gastric injury, and in severe situations, ulcer could develop. The growth factors known asthe basic fibroblast growth factor (bFGF) and the epidermal growth factor (EGF) have been recognized to promoteulcer healing. Fucoidan is extracted from a brown seaweed of Okinawa called Mozuku or Cladosiphon okamuranus.Fucoidan is effective for the healing of gastric ulcers by inducing epithelial cells to produce growth factors. The aimof this study is to explore the efficacy of fucoidan in patient who suffered by gastric ulcer. A randomized control trialdouble blind was conducted to 33 eligible samples. By using four-blocks random samples were divided into fucoidanand placebo groups. 100 mg of fucoidan was given to the fucoidan group and 100 mg of glucose was given to theplacebo group. Due to ethical reasons, for both groups were given a proton pump inhibitor. There was no differencein the age category between the fucoidan group (mean: 46.23 ± 14.8 years) and the placebo group (mean: 46.18 ± 18.4years) (p: 0.28). There was also no difference in sex between the fucoidan group (female: 10/33; male 7/33) and theplacebo group (female: 7/33; male: 9/33); p: 0.38. According to the SAKITA and MIWA criterias 32 patients fulfilledA1 which indicate active severe ulcer, and 1 patient fulfilled A2 which indicate active moderate ulcer. Most of theulcers were gastric ulcer. There was a significant improvement of the grade of ulcer in fucoidan group (94%) (16/17)compared to placebo group (37.5%) (6/16,p: 0.005). There was a significant reduction of abdominal pain after 5 daysin the fucoidan group, compared to the placebo group (p: 0.04). Vomiting tends to decrease in day 6 of the fucoidangroup however its proportion is similar with that of the placebo group (p: 0.9). Fucoidan is effective for ulcer healingand reducing ulcer symptoms.Key words : fucoidan, gastric ulcer, anti-peptic activity
Profile and Behaviour of Mother as Factor of Increasing Diarrhea Incidence Children Under Five at Jatinangor District in 2013 Widhyasti, Rahayu; Arisanti, Nita; Rosalina, Ina
Althea Medical Journal Vol 3, No 4 (2016)
Publisher : Althea Medical Journal

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Background: In 2012, data from Health Center of Jatinangor District showed nearly 50% of diarrhea cases occured in children under five at Sayang Village and Cilayung Village. Diarrhea cannot be separated from several factors that influence it, thus to reduce the incidence rate of diarrhea needs description of factors that affect diarrhea in children so that prevention can be done maximally. Objective of this study was to describe profile and behavior of mother as one factor of increasing diarrhea incidence in children under five at Jatinangor.Methods: This study was descriptive with cross-sectional design conducted at Sayang Village and Cilayung Village in October–November 2013. The respondents of this study were 102 mothers who have infants aged 0–59 months thorough cluster sampling methods. Respondent will be interviewed and given validated questionnaire. Results: The result showed that 57.8% of mother aged 25–35 years, mostly graduated from junior high education (41.2%), and 81.4% as a housewife. Most of diarrhea occurred in children under 2 years and female. There were 73.5% mother who exclusively breastfed, 94.1% have good behavior of clean water usage, 61.8% with good hand washing behavior, and 60.8% respondents utilized healthy latrine.Conclusions: This study showed good results in behaviour of exclusive breastfeeding, behavior of clean water usage, behaviour of hand washing with clean and water flow, and behaviour of healthy latrine usage. Other factors might be contributed to increasing diarrhea incidence. [AMJ.2016;3(4):655–60] DOI: 10.15850/amj.v3n4.956
Liver Function Profile of Pediatric Patients with Dengue Viral Infection Admitted to a Tertiary Referral Hospital during the COVID-19 Pandemic Rosalina, Ina; Adrizain, Riyadi; Sari, Chindy Arya; Alam, Anggraini; Setiabudi, Djatnika
Althea Medical Journal Vol 10, No 2 (2023)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n2.2954

Abstract

Background: Dengue infection is endemic in more than 100 countries; 70% of cases occur in Asia. One of dengue infection complication is hepatic dysfunction. The COVID-19 pandemic may cause a delay in seeking treatment and affect severe case of dengue infection when admitted to the hospital. This study aimed to analyze the liver function profile in dengue pediatric patients during the COVID-19 pandemic.Methods: All patients under 18 with confirmed dengue serology (NS-1 immunochromatography or IgM anti-Dengue (ELISA) test and IgG anti-Dengue (ELISA) test) in Dr. Hasan Sadikin General Hospital from 2021–2022 were included in this retrospective study. The patients were categorized based on the modified WHO classification of 2009. Data were processed with SPSS® ver. 25 and analyzed using Chi-Square and One Way-ANOVA.Result: In total, 85 patients were tested for the liver function; most severe dengue patients had abnormal SGOT and SGPT levels (100% vs. 64%).  The SGOT and SGPT levels during the initial admission were higher in the severe dengue group (634 U/l and 271 U/l) and significantly different among groups (p=0.001 and p=0.032). The elevated SGOT (1,339 U/l vs. 203 U/l vs. 87.3 U/l; p=0.014) and SGPT (438 U/l vs. 100 U/l vs. 42.8 U/l; p=0.005) levels were higher in the severe dengue group.Conclusion: The severity of dengue is in line with the increase in SGOT and SGPT levels. During the COVID-19 pandemic, the liver dysfunction persists and may be interfered with by delays in dengue treatment. Early recognition and prompt treatment are needed to decrease morbidity and mortality.
Co-Authors Adrizain, Riyadi Ali Djumhana Anggraini Alam, Anggraini Ariani A, Ariani Djatnika Setiabudi Harjono Ahmad, Harjono Mohammad Juffrie, Mohammad Nita Arisanti Sari, Chindy Arya Wahyu Damayanti, Wahyu Widhyasti, Rahayu