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All Journal Jurnal Gizi dan Pangan Media Gizi Mikro Indonesia Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Jurnal Teknosains Indonesian Journal of Biotechnology Mutiara Medika: Jurnal Kedokteran dan Kesehatan Sari Pediatri GIZI INDONESIA Indonesian Food and Nutrition Progress Berita Kedokteran Masyarakat
Mohammad Juffrie, Mohammad
Bagian Ilmu Kesehatan Anak Fakultas Kedokteran Universitas Gadjah Mada/RSUP Dr. Sardjito, Yogyakarta
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Materials Science & Nanotechnology Mechanical Engineering Medicine & Pharmacology Neuroscience Nursing Public Health

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The Efficacy of Fucoidan on Gastric Ulcer Juffrie, Mohammad; Rosalina, Ina; Damayanti, Wahyu; Djumhana, Ali; A, Ariani; Ahmad, Harjono
Indonesian Journal of Biotechnology Vol 11, No 2 (2006)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (263.732 KB)

Abstract

Hyperacidity causes gastric injury, and in severe situations, ulcer could develop. The growth factors known asthe basic fibroblast growth factor (bFGF) and the epidermal growth factor (EGF) have been recognized to promoteulcer healing. Fucoidan is extracted from a brown seaweed of Okinawa called Mozuku or Cladosiphon okamuranus.Fucoidan is effective for the healing of gastric ulcers by inducing epithelial cells to produce growth factors. The aimof this study is to explore the efficacy of fucoidan in patient who suffered by gastric ulcer. A randomized control trialdouble blind was conducted to 33 eligible samples. By using four-blocks random samples were divided into fucoidanand placebo groups. 100 mg of fucoidan was given to the fucoidan group and 100 mg of glucose was given to theplacebo group. Due to ethical reasons, for both groups were given a proton pump inhibitor. There was no differencein the age category between the fucoidan group (mean: 46.23 ± 14.8 years) and the placebo group (mean: 46.18 ± 18.4years) (p: 0.28). There was also no difference in sex between the fucoidan group (female: 10/33; male 7/33) and theplacebo group (female: 7/33; male: 9/33); p: 0.38. According to the SAKITA and MIWA criterias 32 patients fulfilledA1 which indicate active severe ulcer, and 1 patient fulfilled A2 which indicate active moderate ulcer. Most of theulcers were gastric ulcer. There was a significant improvement of the grade of ulcer in fucoidan group (94%) (16/17)compared to placebo group (37.5%) (6/16,p: 0.005). There was a significant reduction of abdominal pain after 5 daysin the fucoidan group, compared to the placebo group (p: 0.04). Vomiting tends to decrease in day 6 of the fucoidangroup however its proportion is similar with that of the placebo group (p: 0.9). Fucoidan is effective for ulcer healingand reducing ulcer symptoms.Key words : fucoidan, gastric ulcer, anti-peptic activity
ASUPAN CAIRAN DAN STATUS HIDRASI MEMPENGARUHI PROFIL TEKANAN DARAH PADA ATLET SEPAKBOLA REMAJA Penggalih, Mirza Hapsari Sakti Titis; Juffrie, Mohammad; Sudargo, Toto; Sofro, Zaenal Muttaqien
GIZI INDONESIA Vol 39, No 2 (2016): September 2016
Publisher : PERSATUAN AHLI GIZI INDONESIA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36457/gizindo.v39i2.212

Abstract

PENGEMBANGAN FORMULA SIRUP ZINK DARI EKSTRAK IKAN BILIH (Mystacoleucus- padangensis) SEBAGAI ALTERNATIF SUPLEMENTASI ZINK ORGANIK PADA ANAK PENDEK (STUNTED) USIA 12-36 BULAN Yuniritha, Eva; Juffrie, Mohammad; Ismail, Djauhar; Pramono, Suwijiyo
GIZI INDONESIA Vol 38, No 1 (2015): Maret 2015
Publisher : PERSATUAN AHLI GIZI INDONESIA

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Abstract

Sirup zink ekstrak ikan bilih dibuat dari formulasi sirup dengan bahan dasar ikan bilih (mystacoleucus padangensis) yang mempunyai kandungan zink 27,8 mg/100 gram, lebih tinggi dibandingkan bahan pangan lain. Pemanfaatan ekstrak ikan bilih sebagai alternatif suplementasi zink organik untuk mengatasi defisiensi zink perlu diteliti dalam upaya percepatan penanggulangan masalah anak pendek (stunted) pada anak umur 12-36 bulan. Tujuan penelitian ini adalah mengembangkan formula sirup zink dari ekstrak ikan bilih (mystacoleuseus padangensis) sebagai alternatif suplementasi zink organik pada anak pendek (stunted). Penelitian eksperimental laboratorium ini dimulai dari ekstraksi ikan bilih dengan metode yang standar dilakukan di laboratorium Biologi dan Sediaan Cair Fakultas Farmasi Universitas Gadjah Mada Yogyakarta. Ekstrak ikan bilih mengandung kadar zink yang sangat tinggi (161,97 mg/100 gram), di formulasi menjadi formula sirup suspensi, dengan sediaan utama estrak Zink Citrat, Vitamin A dan protein, ditambah sirup simplek (64%), CMC-Na, Asam Citrat, perasa buah dan pewarna. Formula sirup suplementasi zink ini memenuhi syarat International Zinc Nutrition Consultative Group (IZiNCG), dengan 3 formulasi terbaik berdasarkan uji organoleptik, yaitu formula F 4.1, F 2.2 dan F 2.3. Formula sirup zink dari ektrak ikan bilih dapat dijadikan sebagai alternatif suplementasi zink organik untuk menanggulangi defisiensi zink pada anak pendek (stunted).ABSTRACT THE DEVELOPMENT OF ZINC SYRUP FORMULA FROM BILIH FISH EXTRACT (Mystacoleucus-padangensis) AS AN ALTERNATIVE FOR ZINC ORGANIC SUPPLEMENTATION IN STUNTED CHILDREN AGED 12-36 MONTH The extract of bilih fish (mystaleuseuspadangensis) zinc syrup is made from basic ingredient of bilih fish which contains 27,8 mg zinc/100 gram syrup. It is much higher than other food zinc source. The use of the extract of bilih fish as an alternative of organic zinc supplementation can be used for those who have zinc deficiency. Therefore, it is essential to be studied as an alternative intervention program for stunting in children aged 12-36 months. This objective of this study is to develop zinc formula syrup from the extract of bilih fish (mystaleuseuspadangensis) as an organic zinc supplementation for stunted children. This laboratory experimental research is begun by extracting the fish bilih using a standard method. The extract of bilih fish is formulated in the form of suspension syrup, at the laboratory of Biology and Liquid Preparation in the Faculty of Pharmacy, Gajah Mada University in Yogyakarta. The extract of bilih fish is very high in zinc content (161, 97 mg/100 gram), with main preparation of Zinc Citrate, Vitamin A and protein, added with simplex syrup (64%), CMC-Na, Citric Acid, fruit flavor and food color subtances. This supplement syrup formula is based on International Zinc Nutrition Consultative Group (IZiNCG), with 3 best formulas based on organoleptic test, formula F 4.1, F 2.2 and F 2.3. The zinc syrup formula from extract of bilih fish could be an alternative of organic zinc supplementation to address zinc deficiency in stunted children.Keywords: extract bilih, zinc supplementation, stunting
ASUPAN CAIRAN DAN STATUS HIDRASI MEMPENGARUHI PROFIL TEKANAN DARAH PADA ATLET SEPAKBOLA REMAJA Penggalih, Mirza Hapsari Sakti Titis; Juffrie, Mohammad; Sudargo, Toto; Sofro, Zaenal Muttaqien
GIZI INDONESIA Vol 39, No 2 (2016): September 2016
Publisher : PERSATUAN AHLI GIZI INDONESIA

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Abstract

Athletes tend move with a higher intensity and longer than a normal healthy human being. High intensity exercise coupled with high environmental temperature leads to an increase in body temperature and increased risk of dehydration. Given that the negative impact of dehydration on cardiac function and termoregulatori at practice, then the fluid intake and hydration status were closely related to the stability of the heart to maintain the performance. The study was carried out in 4 months. It was  an observational study with a longitudinal cohort design. The total subjects  in this study were 131 teenage footballers. Statistical testing using multiple regression analysis. The study showed that fluid intake and hydration status, and change in  body weight of the subjects before and after exercise provided significant effect on systolic blood pressure (P<0.05). Every increased in fluid intake and changes in body weight lowers blood pressure by 0.408 systolic mmHg, and increased in fluid intake and changes in percent body weight increase in blood pressure of 2.762 mmHg. The study concluded that intake of fluids as dehydration status protects athletes due to fluid loss. It was  because the activities becomes an important key to re-establish the systolic blood pressure. The more frequent training, the more increasingly athletes being exposed to dehydration, so that the systolic blood pressure  would continue to increase. It was recommended that rehydration for athletes - who experienced a weight loss of more than 2% - should be done immediately after exercise, asuming that 1 kg of body weigth loss could be replaced by at least 1 litter of fluid.
Hubungan Tanda dan Gejala Klinis terhadap Kejadian Syok pada Pasien Demam Berdarah Dengue (DBD) di RS PKU Muhammadiyah Gamping Daerah Istimewa Yogyakarta Kurniawan, Muhammad; Juffrie, Mohammad; Rianto, Bambang Udji Djoko
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2015)
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v15i1.2487

Abstract

Infeksi dengue merupakan penyakit endemis di negara-negara beriklim tropis dan subtropis dengan angka morbiditas dan mortalitas tinggi. Sindrom syok dengue merupakan manifestasi klinis infeksi dengue yang paling membahayakan, bila tidak mendapat penanganan secara tepat akan menyebabkan kematian. Penilaian akurat terhadap risiko syok merupakan kunci penting menuju tatalaksana yang adekuat, mencegah syok, dan perdarahan. Tujuan penelitian ini adalah untuk mengetahui tanda dan gejala yang berhubungan terhadap kejadian syok pada pasien DBD. Penelitian ini merupakan jenis penelitian analytic observational dengan desain cross sectional dengan memilih pasien dewasa yang terdiagnosis demam berdarah dengue menurut kriteria WHO 1997 dan dikonfirmasi dengan pemeriksaan serologi di RS PKU Muhammadiyah Gamping dari Januari-April 2015. Analisis bivariat menggunakan uji Chi-square. Hasil penelitian didapatkan 154 pasien DBD yang memenuhi kriteria dan 17 (11%) diantaranya mengalami kejadian syok. Analisis bivariat diperoleh variabel yang mempunyai hubungan signifikan dengan kejadian syok adalah letargi (p=0,001), ascites (p=0,001), efusi pleura (p=0,001), dan hepatomegali (p=0,001). Disimpulkan bahwa letargi, ascites, efusi pleura, dan hepatomegali adalah variabel yang berhubungan terhadap kejadian syok.Dengue infection is an endemic disease in countries with tropical and subtropical with high morbidity and mortality. Dengue shock syndrome is the most dangerous clinical manifestation of dengue infections, if the patient not receive proper treatment will cause mortality. An accurate assessment of the clinical signs dan symptoms as risk factors of shock is an important key to prevent shock, bleeding, and adequate management. The research to determine clinical signs and symptoms related to shock in patients with DHF. The research methods is analytic observational study with cross sectional design by selecting adult patients diagnosed with dengue hemorrhagic fever, according to WHO criteria in 1997 and confirmed by serology test at RS PKU Muhammadiyah Gamping from January to April 2015. The bivariate analysis using Chi-square test. Research showed 154 dengue patients who matched with the criteria and 17 of patients (11%) experiencing shock dengue. From the results of bivariate analysis showed that variables lethargy (p=0,001), ascites (p=0,001), pleural effusion (p=0,001), and hepatomegaly (p=0,001) have a significant relationship with the occurrence of shock. It can be concluded that lethargy, ascites, pleural effusion, and hepatomegaly are variables related to the occurrence of shock.
Chronic constipation as a risk factor of urinary tract infection in children Irna Fajri Syahny; Mohammad Juffrie; Pungky Ardany Kusuma
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 45, No 04 (2013)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (222.482 KB) | DOI: 10.19106/JMedScie004504201306

Abstract

The prevalence of urinary tract infection (UTI) in children is still quite high. In Dr. SardjitoGeneral Hospital, Yogyakarta the incidence of UTI is reported about 3.5%. One of the riskfactors of the incidence of UTI is chronic constipation. However, it is often not a concern in themanagement of UTI pediatric patients. The aim of the study was to evaluate the influence ofchronic constipation in increasing the risk of UTI in children. This was an observational studywith case-control design. Children with symptoms of UTI who visited at the Installation of ChildHealth, Dr. Sardjito General Hospital, Yogyakarta underwent dipstick urinalysis test and urineculture examination. Patients who showed positive urine culture was included in the case group,meanwhile patients who showed negative urine culture was included in the control group. Allpatients were then asked the history of the chronic constipation. The association between theconstipation and the incident of UTI was evaluated using bivariate analysis continued bymultivariate analysis. One hundred and twenty eight eligible subjects consisting 64 subjects ineach group were involved in this study. Statistical analysis showed that children with chronicconstipation have a 3.77 times higher risk of UTI (OR=3.77; 95%CI=3.21-4.32) compare tothose without constipation. Furthermore, the chronic constipation remained to be independentrisk factor of UTI. The incidence of UTI increased 3.99 times higher in children with constipationcompare to those without constipation (aOR=3.99; 95% CI=1.028-15.48). In conclusion, chronicconstipation has been proven to be a risk factor of UTI in children
Could CD8/38 predict virological response to antiretroviral therapy (ART) in human immunodeficiency virus (HIV) infected patients? Umi S. Intansari; Yanri W Subronto; Yunika Puspa Dewi; Adika Zhulhi Arjana; Mohammad Juffrie; Marsetyawan HNE Soesatyo; Budi Mulyono
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 47, No 2 (2015)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (996.474 KB) | DOI: 10.19106/JMedSci004702201504

Abstract

ABSTRACT The success rate of antiretroviral therapy (ART) depends on the efficacy of the drug and the immune system’s ability to control virus replication. Viral load (VL) examination is a standard test for ART monitoring. Unfortunately, this test is still very limited, especially in Indonesia. CD38 expression has been studied as a predictor for disease progression and decreases once ART is initiated. The aim of this study was to evaluate the possible usage of declining CD8/38 T-cell percentages in predicting the VL. Forty-five subjects naïve to ART were evaluated in this observational analytic study with a prospective design. Data collected included the medical history, physical examination, WHO clinical staging, complete blood counts, CD4 cell count, and plasma VL. These data then reevaluated six months after ART initiation. A paired t-test, and correlation test were used to analyze the data. Significant differences were found in all of the laboratory parameters between pre and post ART. There was a weak significant positive correlation between declining CD8/38 T-cell percentages and declining VL after 6 months of ART (r=0.33; p=0.026), with r2 = 0.11. Therefore despite the linear relationship, CD38 has limited value for prediction of VL.
ROLE OF REDUCING CELL LEAKAGE IN CELL CULTURE USING LARGE PORE SIZE PERMEABLE MEMBRANE Nur Kaliwantoro; Marsetyawan HNE Soesatyo; Indarto Indarto; Mohammad Juffrie; Rini Dharmastiti; Suprihatin Suprihatin
Jurnal Teknosains Vol 6, No 1 (2016): December
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/teknosains.27192

Abstract

Permeable membranes are widely used in many in vitro studies using cell culture. Some cell leakage are often occurs when using permeable membrane with large pore size. Unfortunately the use of permeable membrane with smaller pore size in permeability studies faces some difficulties due to its small pore size and pore density. Recent study provides the protocol in using permeable membrane with large pore size with smaller cell leakage. Vero cell line (CCL-81, ATCC) was used and culture on polyester permeable membrane with 3 µm pore size. Visualization using inverted microscope was used to analized the cell leakage on the permeable membrane. Parallel plate flow chamber was used to analized the permeability performance of the Vero cell cultured on the permeable membrane. The result showed that the current technique is significant in reducing cell leakage of the cell cultured on large pore size of permeable membrane. The same results were found in using polyester and polycarbonate permeable membrane.
IRON-FORTIFIED SYNBIOTIC FERMENTED MILK WITH TEMPEH EXTRACT TO ENHANCES PROPIONIC ACID, BUTYRIC ACID, AND NON-PATHOGEN MICROBIOME IN ANEMIC WISTAR RAT Mohammad Juffrie; Siti Helmyati
Media Gizi Mikro Indonesia Vol 11 No 2 (2020): Media Gizi Mikro Indonesia Juni 2020
Publisher : Balai Penelitian dan Pengembangan Kesehatan Magelang

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (324.549 KB) | DOI: 10.22435/mgmi.v11i2.2694

Abstract

Background. Anemia, as a global public health problem, needs to be solved. The previous study by the researcher found the potency of iron-fortified synbiotic fermented milk with tempeh extract as an alternative to overcome anemia. Objective. This study aims to determine the effects of iron-fortified synbiotic fermented milk with tempeh extract towards short-chain fecal fatty acids (SCFAs) and fecal microbiota. Method. The study was a randomized controlled trial with three groups, consisting of 8 anemic Wistar rats. The groups made into anemia within 17 days.The groups treated as follows: group NA: fermented milk with tempeh extract fortified by NaFeEDTA, group FE: fermented milk with tempeh extract fortified by FeSO4 , and group KO: fermented milk with tempeh extract without fortification. SCFAs and microbiota of the rat’s feces determined using the Total Plate Count method. SCFAs were measured after the intervention, while fecal microbiota was measured before and after the intervention. One-way ANOVA was used to measure the difference between NA, FE, and KO groups with post hoc test Bonferroni. Results. There was a significant mean difference between propionic and butyric acid between NA and FE groups and the KO group. The highest Lactobacilli number was in the FE group, while Bifidobacteria and Enterobacteriaceae were highest in the KO group. Meanwhile, the NA group had the highest Escherichia coli number. Conclusion. Iron fortification has positive effects on increasing the production of SCFAs in the gut. Prebiotics and probiotics have positive effects on pathogenic bacteria. Further study is needed to determine the effects of iron-fortified synbiotic fermented milk with tempeh extract in human.
Faktor Prognosis Derajat Keparahan Infeksi Dengue Arie Yulianto; Ida Safitri Laksono; Mohammad Juffrie
Sari Pediatri Vol 18, No 3 (2016)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp18.3.2016.198-203

Abstract

Latar belakang. Infeksi virus dengue (IVD) bersifat akut dan dinamis, perjalanan klinisnya terkadang sulit diprediksi sehingga berakibat keterlambatan pengelolaan. Maka perlu diteliti parameter klinis dan laboratoris di fase kritis / defervescence untuk memprediksi derajat keparahan infeksi dengue.Tujuan. Mengetahui parameter klinis dan laboratoris sebagai faktor prognosis derajat keparahan infeksi dengue.Metode. Penelitian kohort retrospektif, menggunakan data rekam medik pasien anak IVD yang dirawat di RSUP Dr. Sardjito Yogyakarta dari Januari 2014 – Desember 2015. Faktor prognosis yang diteliti adalah usia, jenis kelamin, tanda klinis warning signs, serta laboratorium. Kriteria eksklusi adalah adanya penyakit hematologi dan penyakit jantung bawaan. Analisis statistik denganmetode regresi logistik.Hasil. Di antara 188 pasien yang memenuhi kriteria penelitian, 56 (30%) didiagnosis demam dengue (DD), 58 (31%) demam berdarah dengue derajat 1 – 2 (DBD), dan 74 (39%) sindrom syok dengue (SSD). Analisis multivariat menunjukkan nyeri perut (OR 5,06, IK 95%: 1,72;14,87), hepatomegali >2 cm (OR 7,57, IK 95%: 2,86;20,02), hematokrit >45% (OR 5,10, IK 95%: 1,74;14,95), dan trombosit ≤50.000/uL (OR 17,80, IK 95%: 3,78;83,80) merupakan faktor prognosis independen derajat keparahan infeksi dengueKesimpulan. Nyeri perut, hepatomegali >2 cm, hematokrit >45% dan trombosit ≤50.000/uL di fase defervescence merupakan faktor prognosis independen terjadinya infeksi dengue yang lebih berat (DBD dan SSD).
Co-Authors Abd. Rasyid Syamsuri Adika Zhulhi Arjana Akhmadi Akhmadi Ali Djumhana Amalia Setyati Aprilia Choirun Nisa Ariani A, Ariani Arie Yulianto Budi Mulyono Djauhar Ismail Endang Sutriswati Rahayu Endri Yuliati Eva Yuniritha, Eva Harjono Ahmad, Harjono Hasan, Pratama Nur Helmyati, Siti I Gusti Wayan Murjana Yasa Ida S. Laksanawati Ida Safitri Laksono Ina Rosalina Indarto Indarto Irna Fajri Syahny Jamil, Muhammad Dawam Krisnanto Wibowo Kurniasari, Yulinda Maghribi, Risnhukathulistiwi Manurung, Nancy Eka Putri Marsetyawan HNE Soesatyo Marsetyawan HNE Soesatyo Mei Neni Sitaresmi Mirza Hapsari Sakti Titis Penggalih Neti Nurani Nur Kaliwantoro Pungky Ardany Kusuma Rini Dharmastiti Rini Yanti, Rini Sari, Endah Mayang Siti Helmyati Sitti Ridha Khairani Fatah Sofro, Zaenal Muttaqien Sri Mulatsih Suprihatin Suprihatin SUWIJIYO PRAMONO Toto Sudargo Tyas Utami Wahyu Damayanti, Wahyu Wisnusanti, Setyo Utami Yanri W Subronto Yunika Puspa Dewi