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All Journal Nexus Biomedika JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Aflifia Birruni Sabila
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Biochemistry, Genetics & Molecular Biology Medicine & Pharmacology Public Health

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Pengaruh Pemberian Ekstrak Biji Mahoni (Swietenia mahagoni Jacq.) terhadap Penurunan Kadar Alanin Transaminase Mencit (Mus musculus) yang Diinduksi Parasetamol Sabila, Aflifia Birruni; Putranto, R.P. Andri; Martini, .
Nexus Biomedika Vol 2, No 2 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (13.862 KB)

Abstract

Background: Seeds of Swietenia mahagoni Jacq. contain various antioxidants such as alkaloids, saponins, flavonoids, triterpenoids, steroids, and tannins. They are thought having hepatoprotector effect. This study aimed to know the influence of Swietenia mahagoni Jacq. to decrease alanin transaminase level in paracetamol-induced mice. Methods: Samples were 25 male mice, Swiss webster strain, 2-3 months old  and + 25 g of weight, each. Samples were divided into 5 groups, each group consisted of 5 mice. Group K(-) were administered aquadest, while group K(+) were administered curcuma with the dose of 25 mg/25 g body weight of mice for 14 days. Group  P1, P2 and P3 were consecutively administered mahagony seed extract with the dose of 0 mg, 14 mg and 28 mg/25 g body weight of mice for 14 days. Paracetamol was administered to groups of K(+), P1, P2, and P3 on the 12th, 13th, and 14th day. On the 15th day, blood samples were taken and the ALT (alanine transaminase) level was measured with a Model 902 Automatic Analyzer Hitachi. Data were analyzed by the Kruskal-Wallis test (α = 0.05) and Post Hoc Mann Whitney test (α = 0.05). Results: Mean rate of alanine transmainase of group K(-), K(+), P1, P2 and P3 was 54.04  ± 7.74 U/L; 46.74 ± 3.33 U/L; 173.5 ± 39.445 U/L;  88.90 ± 37.04 U/L and 73.18 ± 7.46 U/L, consecutively Conclusions: There was correlation between the oral administration of mahagony seed extract (Swietenia mahogany Jacq.) and the decrease of alanin transaminase level in paracetamol-induced mice. Keywords: Alanin Transaminase (ALT), Seed extract of Swietenia mahagony Jacq.,
Pengaruh Pemberian Ekstrak Biji Mahoni (Swietenia mahagoni Jacq.) terhadap Penurunan Kadar Alanin Transaminase Mencit (Mus musculus) yang Diinduksi Parasetamol Aflifia Birruni Sabila; R.P. Andri Putranto; . Martini
Nexus Biomedika Vol 2, No 2 (2013): Nexus Biomedika
Publisher : Nexus Biomedika

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Background: Seeds of Swietenia mahagoni Jacq. contain various antioxidants such as alkaloids, saponins, flavonoids, triterpenoids, steroids, and tannins. They are thought having hepatoprotector effect. This study aimed to know the influence of Swietenia mahagoni Jacq. to decrease alanin transaminase level in paracetamol-induced mice. Methods: Samples were 25 male mice, Swiss webster strain, 2-3 months old and + 25 g of weight, each. Samples were divided into 5 groups, each group consisted of 5 mice. Group K(-) were administered aquadest, while group K(+) were administered curcuma with the dose of 25 mg/25 g body weight of mice for 14 days. Group P1, P2 and P3 were consecutively administered mahagony seed extract with the dose of 0 mg, 14 mg and 28 mg/25 g body weight of mice for 14 days. Paracetamol was administered to groups of K(+), P1, P2, and P3 on the 12th, 13th, and 14th day. On the 15th day, blood samples were taken and the ALT (alanine transaminase) level was measured with a Model 902 Automatic Analyzer Hitachi. Data were analyzed by the Kruskal-Wallis test (? = 0.05) and Post Hoc Mann Whitney test (? = 0.05). Results: Mean rate of alanine transmainase of group K(-), K(+), P1, P2 and P3 was 54.04 7.74 U/L; 46.74 3.33 U/L; 173.5 39.445 U/L; 88.90 37.04 U/L and 73.18 7.46 U/L, consecutively Conclusions: There was correlation between the oral administration of mahagony seed extract (Swietenia mahogany Jacq.) and the decrease of alanin transaminase level in paracetamol-induced mice. Keywords: Alanin Transaminase (ALT), Seed extract of Swietenia mahagony Jacq.,
Intake of F-100 and honey as an effort to improve the nutritional status of children with pediatric tuberculosis Machfudz, Soeroyo; Rachmawaty, Farida Juliantina; Sabila, Aflifia Birruni
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 3, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss3.art6

Abstract

Background: Stunting remains a significant nutritional challenge in Indonesia. If malnutrition in children is not addressed appropriately, it can lead to stunting. Children under five years old with pediatric tuberculosis (TB) are particularly susceptible malnutrition. Specific interventions are needed to prevent stunting in this vulnerable group.Objective: The study aimed to improve the nutritional status of children with pediatric TB to prevent stunting. Methods: This study included 44 children under five years old with pediatric TB, who were patients at a private hospital and clinic. The subjects were divided into four groups of 10-12 children based on their arrival for treatment. Group A received standard medicine, F-100, and pure honey; Group B received standard medicine and F-100; Group C received standard medicine and pure honey; and Group D received only standard medicine. The F-100 and pure honey were administered once daily. Each group was followed up for six weeks. Weight and height were measured before and after the intervention. Statistical analysis was performed with a 95% confidence level.Results: Administration of F-100 and/or honey significantly increased Z scores for height-for-age, weight-for-age, and weight-for-length/height between the pre-test and post-intervention (p < 0.05). Conversely, no significant improvement was observed in children receiving only standard medication (p > 0.05). The differences in Z score increases between groups, however, were not statisticallysignificant. Overall, the intervention reduced the prevalence of wasting (36.4% to 22.75%) and stunting (36.4% to 29.5%)Conclusion: Supplementation with F-100 and honey improved nutritional outcomes but did not show statistically significant differences between groups. Further research is recommended to explore the effects of increased frequency and duration of supplementation.
Co-Authors . Martini . Martini Farida Juliantina Rachmawaty R.P. Andri Putranto R.P. Andri Putranto Soeroyo Machfudz, Soeroyo