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CHAIDIR CHAIDIR
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Combination Gel Formulation Extracts of Moringa Leaf and Red Betel Leaf as an Inhibitor of Acne-Causing Bacteria (Propionibacterium acne and Staphylococcus aureus) Eko Sri Wahyuningsih; Wahono Sumaryono; Chaidir Chaidir
Jurnal Fitofarmaka Indonesia Vol 8, No 3 (2021): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v8i3.727

Abstract

The most common skin disorder is acne (Acne vulgaris) which is a chronic inflammatory disease that occurs in the pilosebaceous unit. Infection can be caused by Propionibacterium acnes and Staphylococcus aureus. Moringa leaves are known to inhibit acne growth. Piper crocatum leaves are also thought to have antibacterial activity. The study aims to determine the effect of the combination of the two extracts in inhibiting the growth of acne-causing bacteria, also tested the gel formula to meet physical and chemical parameters as well as stability to temperature and storage, also to test the acute dermal irritation against rabbit. Each extract with a concentration of 0.3%; 0.6%; 1.25%; 2.5%; 5%; 10%; 20%, incubated then measured the inhibition zone, then determined the minimum inhibition zone concentration of the two extracts to determine the lowest levels of the extracts which still gave antibacterial activity against the tested bacteria by the well diffusion method. The extract combination was formulated in a gel preparation with the excipients Carbopol 940, PG, Phenoxyethanol, TEA, CMC, and Aquadest. Antibacterial activity test for gel preparations used the well method with positive control Medi-Klin® gel. Then the formula evaluation includes physical, chemical, and microbiological evaluations. The results showed that the combination gel form had activity against P. acne and S. aureus at concentrations of 2.5% : 2.5%. The combination gel preparation of the two extracts also has synergistic effect in inhibiting acne bacteria. The formula can meet physical and chemical parameters and is stable to temperature and storage.
Optimasi Dan Identifikasi Fitokimia Serta Uji Efek Hipoglikemik Kombinasi Ekstrak Daun Dandang Gendis (Clinacanthus nutans) Dan Ekstrak Ciplukan (Physalis angulata L.) Secara In Vitro U. Widayat; Chaidir Chaidir; Siswa Setyahadi
Jurnal Fitofarmaka Indonesia Vol 9, No 1 (2022): JURNAL FITOFARMAKA INDONESIA
Publisher : Faculty of Pharmacy, Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/jffi.v9i1.810

Abstract

Diabetes mellitus is a metabolic disease characterized by hyperglicemic. Dandang Gendis (Clinacanthus nutans) and Ciplukan (Physalis angulata L.) are plants which recognized as blood glucose controller. The study aims to determine the effectiveness of the combination of the two extracts in decreasing blood sugar levels in vitro. The leaves of dandang gendis and ciplukan were extracted with various solvents (hot water, cold water, 96% ethanol, 75% ethanol, 50% ethanol and 30% ethanol were used as solvents), then tested the quality of the simplicia and extract, then the phytochemical test of each extract, after that the hypoglycemic activity of each extract was tested, made several variations of the dose, then tested the antidiabetic activity of the combination extract, calculated percent protection and percent effectiveness of single extract and a combination of leaf extract of dandang gendis (Clinacanthus nutans) and ciplukan (Physalis angulata L).The results showed that inhibition of the α-amylase enzyme by extracts of Dandang Gendis, Ciplukan and their combinations included the combination of EE96% 10 mg (1:1) of 1.25 ppm; Combination of EE96% 10mg (1:2) of 6.340 ppm; Combination of EE96% 10mg (2:1) of 5.808 ppm; The combination of EE96% 10mg (2:2) was 7.115 ppm and the IC50 acarbose value was 4.23 ppm. Dandang Gendis extract, Ciplukan and their combination had α-amylase inhibitory activity which was not significantly different between the extract and the control Acarbose. Inhibition of α-amylase enzyme activity could be influenced by metabolites and total phenolic extracts of Gendis, Ciplukan and their combinations.
Identifikasi Lektin Umbi dari Typhonium flagelliforme (Lodd.) Blume MUHAMMAD ALFARABI; SISWA SETYAHADI; MARIA BINTANG; MIFTAHUDIN MIFTAHUDIN; CHAIDIR CHAIDIR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 14 No 1 (2016): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (514.087 KB)

Abstract

Typhonium flagelliforme atau yang dikenal dengan keladi tikus merupakan tumbuhan perdu yang banyak tumbuh di Indonesia. Tumbuhan ini mengandung lektin pada umbinya yang memiliki aktivitas antikanker. Namun hingga saat ini, tidak ada informasi ilmiah yang mengkaji mengenai lektin yang terdapat di umbi T. flagelliforme yang tumbuh diberbagai wilayah Indonesia. Tujuan dari penelitian ini adalah untuk mengidentifikasi dan mengkarakterisasi lektin umbi dari tujuh aksesi T. flagelliforme di Indonesia. Umbi yang digunakan dalam penelitian berumur 6 bulan tanam. Ekstrak protein umbi yang didapat dianalisis kandungan protein, toksisitas, dan aktivitas hemaglutinasinya. Aksesi yang memiliki aktivitas hemaglutinasi tertinggi, lektinnya dipurifikasi menggunakan kolom DEAE-Sepharose dan CM monolitic. Hasil menunjukkan bahwa protein umbi dari setiap aksesi memiliki toksisitas dan aktivitas hemaglutinasi. Aksesi Solok memiliki total protein dan aktivitas hemaglutinasi tertinggi dibanding aksesi lainnya. Aksesi ini memiliki kandungan lektin dengan bobot molekul 12,67 kDa. Lektin ini stabil pada temperatur 20 hingga 40 °C dan pada pH 5,0 hingga 7,2. Informasi karaktersitik ini dapat membantu dalam pengembangan obat antikanker berbasis lektin.
Co-Authors Eko Sri Wahyuningsih MARIA BINTANG Miftahudin . Muhammad Alfarabi Siswa Setyahadi SISWA SETYAHADI U. Widayat Wahono Sumaryono