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Syarmalina Syarmalina
Universitas Pancasila
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Isolasi dan Uji Antimikroba Substansi Bioaktif Mikroba Endofit Ranting Tanaman Johar (Cassia siamea Lamk.) Shirly Kumala; Syarmalina Syarmalina; Atut Ruswita Handayani
JURNAL ILMU KEFARMASIAN INDONESIA Vol 4 No 1 (2006): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Assay for secondary metabolite of endophytic fungi from Cassia siamea Lamk.. (Johar Plant) has been investigated. Endophyitic fungi are microorganisms that live asymtomatically within the living tissue of host plants. Endophytic fungi associate with plant, they can help the metabolism of host plant and produce potensial secondary metabolite. The purpose of this experiment were to investigate endophytic microbial agents. Isolate of endophytic fungi from twig of Cassia siamea Lamk., using direct seed method was carried out. The microbial activity was carried out with dilution method using paper disk and glass cylinder. The results showed 3 isolates of bacteria and 7 isolates of endophtyic fungi. The metabolite from three isolates of bacteria had the anti-microbial activity more poten toward Gram positive than Gram negative and four isolates of fungi had anti-Aspergillus agent.
Formulasi Edible Film Ekstrak Daun Sirih (Piper betle L.) sebagai Antihalitosis MOCH FUTUCHUL ARIFIN; LILIEK NUR HIDAYATI; SYARMALINA SYARMALINA; RENSY RENSY
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Halitosis (bad breath) is the most complained problem among mouth and teeth health. The source of halitosis are volatile sulfur compounds produced by Streptococcus mutans from degradation of food debris. Sirih leaves (Pqaer betle L.) are traditionally used as mouth antiseptic for its volatile oil. The aim of this research was to formulate sirih extract into an edible film. The leaves were macerated with 96% ethanol for 24 hours, resulting to an extract with minimum inhibitory concentration (MIC) on Streptococcus mutans of 8.49x10-3 g/ml. The extract with strength quadruple of the MIC, or equal to 0.92% povidone iodine, was formulated using 23 factorial design. Com starch, hydroxypropyl methylcellulose (HPMC) and sorbitol were independent variables and drying time, moisture, hlm thickness, disintegrating time, and iilrn strength were the dependent ones. The results showed that HPMC significantly fastened the drying time, decreased the moisture, and lengthened the disintegrating time. Sorbitol significantly lengthened the drying time, increased the moisture, and strengthened the film, while corn starch decreased the moisture and lengthened the disintegrating time. Optimation of the formula ingredients using contour plot superimposed cannot be determined due to edible film disintegrating time that was out of comparative interval.
Uji Sitotoksik Hasil Fermentasi Kapang Endofit Buah Mahkota Dewa (Phaleria macrocarpa) terhadap Sel MCF-7 Syarmalina Syarmalina; Wan Lely; Nazliah Laupa
JURNAL ILMU KEFARMASIAN INDONESIA Vol 5 No 1 (2007): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

In the development of traditional medicine, there are great demands of medicinal plant. Meanwhile, those demands exceed the capacity of natural resource to provide the raw material. The solution for that problem that has been developed is by utilizing organism that live on plant tissue, which known as endophytic microbe. The preliminary Brine Shrimp Lethality Test based research on the polarity degree of supernatant extracts has proved that it has high toxic activity on Artemia salina Leach. Subsequent to that study, a research to examine in vitro cytotoxic effect of supernatant extract fermented from Mahkota Dewa fruit endophytic mould KVM/a and KIVM/b isolate on breast cancer cell has been conducted. Thin layer chromatographic test was performed to identify the patch pattern from each fraction of KVM/a and KIVM/b isolate. Furthermore, preparative thin layer chromatographic test was tested on MCF-7 cell by using neutral red method. The cytotoxic effect was determined based on ICs, value. The results confirm the cytotoxic test effect of semi polar fraction of both isolates on MCF-7 cell with the ICs, value of 36.26 ppm for KVM/a and 30.48 ppm for KIVM/b.
Optimasi Formula Emulgel Serbuk Kasar Papain MOCH FUTUCHUL ARIFIN; SYARMALINA SYARMALINA; DIANA SYARMALINA; SHAFA NABILAH; DIDA MAULIDA HASANAH; HIFZIEL AZHAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Crude powder of papain is very irritative and unstable, thus it should be formulated in emulgel using factorial design 2. The purpose of the study was to assess the effect of gelling agent (2.5% HPMC, 1 % Carbomer 940 ), oil phase ( liquid paraffin 5% to 7.5 % ), emulsifier ( 1.5% -2% Tween 80 - Span 80) and determine the optimum formula. Viscosity, ease of spread, proteolytic activity and antimicrobial activity of papain emulgel were used as the parameters in formula optimization. Each parameter had a contour plot. With the use of superimposed countor plot, the shaded area could be determined as the optimum formula. The results of the factor effect analysis and its interactions were that gelling agent gave significant effect (p<0.05) and dominant in increasing the viscosity of emulgel and the activity of papain proteolytic enzyme. However, it decreased the diameter of the dispersing area and the inhibition zone diameter. The increase in the concentration liquid paraffin concentration had a dominant and significant effect towards the improvement of the emulgel’s dispersive power and the proteolytic activity of papain. The increase in the combination of Tween 80-Span 80 emulgator had a dominant and significant effect towards the improvement of viscosity and the decrease in the dispersive power, the proteolytic activity, and the inhibition zone diameter. From the superimposed contour plots analysis and response optimizer, the optimum formula was achieved by 2.5% of HMPC gelling agent, 5.6% of liquid paraffin, and 2.4% of emulsifier combination.
Co-Authors Atut Ruswita Handayani DIANA SYARMALINA DIDA MAULIDA HASANAH HIFZIEL AZHAR LILIEK NUR HIDAYATI Moch Futuchul Arifin Nazliah Laupa RENSY RENSY SHAFA NABILAH Shirly Kumala Wan Lely