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All Journal Jurnal Ilmu Kefarmasian Indonesia Jurnal Farmamedika (Pharmamedica Journal) Sainstech Farma: Jurnal Ilmu Kefarmasian Sciences of Pharmacy
Moch Futuchul Arifin
Fakultas Farmasi, Universitas Pancasila
Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Optimization of Extract Concentration and Polyvinyl Pirolidon Binding Material on Granule Red Betel Leaves Extract (Piper crocatum Ruiz & Pav) as Antihyperuricemic Dian Ratih Laksmitawati; Liliek Nurhidayati; Mochamad Futuchul Arifin; Bagus Bahtiar
JURNAL ILMU KEFARMASIAN INDONESIA Vol 15 No 2 (2017): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (290.799 KB) | DOI: 10.35814/jifi.v15i2.527

Abstract

Ethanolic extract of red betel leaves (Piper crocatum Ruiz & Pav) has antihyperuricemic activity. In order to be applicable to consume, this extract need to be formulated into pharmaceutical dosage form. Granules which is packed in a tea sac bag was considered to be more practical andappropriate for person suff ering hyperuricemic, because they have to drink more water. In the granulation process, the he binder plays an important role so that this study aims to fi nd the optimal red betel leaf granule formula with variation on the extract dose and the polyvinyl pyrolidone (PVP) binder and prove granule activity in vivo in mouse hyperuricemia model. The extract was prepared by macerationthe leaves in 96% ethanol and sprayed dried by hot air. The powder was then formulated to granules form in 22 factorial design. The factors were the extract dosages (38% dan 47.51%) dan the amount of PVP (Polyvinyl Pyrrolidone) as a binder (0.5% dan 2%). The physical and chemical properties of the granules were evaluated, interaction dosage, PVP concentration and each properties was analysed by making the contour plot and superimposed contour plot to get the optimum formula. The in vivo antihyperuricemic activity of the granules was determined in hyperuricemic mice. The result showed that the optimum formula was found in granules that contained 42.5% extract and 1% PVP. At the equivalent dosage of 455 mg extract/kg, this granules formula had antihyperuricemic activity decreasing 54.2 %plasma uric acid level significantly. Thus it can be concluded that the optimum granules of ethanol extract of red betelleaf with 42.5% extra ct content and 1% PVP proved to have antihiperurisemia activity in mice induced by chicken extractand potassium oxonate.
Formulasi Edible Film Ekstrak Daun Sirih (Piper betle L.) sebagai Antihalitosis MOCH FUTUCHUL ARIFIN; LILIEK NUR HIDAYATI; SYARMALINA SYARMALINA; RENSY RENSY
JURNAL ILMU KEFARMASIAN INDONESIA Vol 8 No 1 (2010): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (1679.648 KB)

Abstract

Halitosis (bad breath) is the most complained problem among mouth and teeth health. The source of halitosis are volatile sulfur compounds produced by Streptococcus mutans from degradation of food debris. Sirih leaves (Pqaer betle L.) are traditionally used as mouth antiseptic for its volatile oil. The aim of this research was to formulate sirih extract into an edible film. The leaves were macerated with 96% ethanol for 24 hours, resulting to an extract with minimum inhibitory concentration (MIC) on Streptococcus mutans of 8.49x10-3 g/ml. The extract with strength quadruple of the MIC, or equal to 0.92% povidone iodine, was formulated using 23 factorial design. Com starch, hydroxypropyl methylcellulose (HPMC) and sorbitol were independent variables and drying time, moisture, hlm thickness, disintegrating time, and iilrn strength were the dependent ones. The results showed that HPMC significantly fastened the drying time, decreased the moisture, and lengthened the disintegrating time. Sorbitol significantly lengthened the drying time, increased the moisture, and strengthened the film, while corn starch decreased the moisture and lengthened the disintegrating time. Optimation of the formula ingredients using contour plot superimposed cannot be determined due to edible film disintegrating time that was out of comparative interval.
Optimasi Formula Emulgel Serbuk Kasar Papain MOCH FUTUCHUL ARIFIN; SYARMALINA SYARMALINA; DIANA SYARMALINA; SHAFA NABILAH; DIDA MAULIDA HASANAH; HIFZIEL AZHAR
JURNAL ILMU KEFARMASIAN INDONESIA Vol 13 No 1 (2015): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

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Abstract

Crude powder of papain is very irritative and unstable, thus it should be formulated in emulgel using factorial design 2. The purpose of the study was to assess the effect of gelling agent (2.5% HPMC, 1 % Carbomer 940 ), oil phase ( liquid paraffin 5% to 7.5 % ), emulsifier ( 1.5% -2% Tween 80 - Span 80) and determine the optimum formula. Viscosity, ease of spread, proteolytic activity and antimicrobial activity of papain emulgel were used as the parameters in formula optimization. Each parameter had a contour plot. With the use of superimposed countor plot, the shaded area could be determined as the optimum formula. The results of the factor effect analysis and its interactions were that gelling agent gave significant effect (p<0.05) and dominant in increasing the viscosity of emulgel and the activity of papain proteolytic enzyme. However, it decreased the diameter of the dispersing area and the inhibition zone diameter. The increase in the concentration liquid paraffin concentration had a dominant and significant effect towards the improvement of the emulgel’s dispersive power and the proteolytic activity of papain. The increase in the combination of Tween 80-Span 80 emulgator had a dominant and significant effect towards the improvement of viscosity and the decrease in the dispersive power, the proteolytic activity, and the inhibition zone diameter. From the superimposed contour plots analysis and response optimizer, the optimum formula was achieved by 2.5% of HMPC gelling agent, 5.6% of liquid paraffin, and 2.4% of emulsifier combination.
Formulasi dan Uji Antibakteri Sediaan Gel Ekstrak Kelopak Bunga Rosela (Hibiscus sabdariffa L.) terhadap Pseudomonas aeruginosa dan Propionibacterium acnes Safira Nafisa; Yuslia Noviani; Moch Futuchul Arifin; Calista Nathania
SAINSTECH FARMA Vol 14 No 1 (2021): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v14i1.933

Abstract

Kelopak bunga rosela (Hibiscus sabdariffa L.) diketahui memiliki aktivitas antibakteri terhadap Pseudomonas aeruginosa dan Propionibacterium acnes. Aktivitas tersebut diduga karena adanya senyawa alkaloid, flavonoid, tanin, dan saponin yang terkandung dalam bunga rosela. Tujuan penelitian ini adalah mendapatkan formula optimum dari sediaan gel ekstrak kelopak bunga rosela yang baik secara fisik, kimia, dan efektivitasnya sebagai antibakteri. Metode yang digunakan adalah rancangan faktorial 23 dengan 3 faktor, yaitu Konsentrasi Hambat Minimum (KHM) ekstrak kelopak bunga rosela (6 dan 12%), carbomer 940 (1,5 dan 2,0%), dan propilenglikol (10 dan 15%). Sediaan gel dievaluasi mutu fisik, kimia, dan efektivitas secara in vitro, kemudian dianalisis menggunakan program Minitab 17 untuk mengetahui pengaruh faktor dan interaksinya terhadap respon yang dihasilkan. Hasil uji fisik sediaan gel yaitu berbentuk semisolid; berwarna coklat; berbau khas rosela; dengan viskositas 19375 – 68750 cPs; pH 4,42 – 5,53; daya sebar 18,39 – 31, 08 cm2; diameter daerah hambat Pseudomonas aeruginosa 10,88 – 14,88 mm; dan diameter daerah hambat Propionibacterium acnes 10,63 – 13,88 mm. Pada penelitian ini diperoleh formula optimum yaitu konsentrasi ekstrak 10.18%, carbomer 940 2%, propilenglikol 15%, trietanolamin 2%, natrium benzoat 0,1%, dan air suling ad 100%. Berdasarkan hal tersebut dapat disimpulkan bahwa sediaan gel yang mengandung ekstrak kering kelopak bunga rosela baik secara fisik dan kimia, serta mampu menghambat pertumbuhan bakteri Pseudomonas aeruginosa dan Propionibacterium acnes.
FORMULASI NANOSUSPENSI EKSTRAK KERING RIMPANG TEMULAWAK (Curcuma xanthorrhiza Roxb.) DENGAN METODE GELASI IONIK DAN UJI AKTIVITAS ANTIOKSIDAN Moch Futuchul Arifin; Yuslia Noviani; Anarisa Budiati; Isnaini Hidayanti
Jurnal Farmamedika (Pharmamedika Journal) Vol 7 No 2 (2022): Jurnal Farmamedika (Pharmamedica Journal)
Publisher : Sekolah Tinggi Teknologi Industri dan Farmasi Bogor

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47219/ath.v7i2.163

Abstract

Temulawak (Curcuma xanthorhiza Roxb.) mengandung kurkumin berkhasiat sebagai antioksidan. Rendahnya kelarutan, ketersediaan hayati dan stabilitas menjadi kendala untuk dikembangkan sebagai sediaan oral. Tujuan penelitian adalah memformulasi ekstrak kering menjadi nanosuspensi antioksidan dengan metode gelasi ionik. Dilakukan optimasi nanosuspensi terhadap empat formula yang mengandung konsentrasi ekstrak kering sebesar : 100-700 x IC50. Penetapan formula optimum dari ke-empat formula berdasarkan: stabilitas, ukuran partikel dan indeks polidispersitas. Formula optimum dikarakterisasi meliputi: morfologi, potensial zeta, efisiensi penjerapan dan aktivitas antioksidan dengan metode DPPH. Formula dengan 100 x IC50 paling stabil, ukuran partikel 300,4 nm dan indeks polidispersitas 0,292 ditetapkan sebagai formula optimum. Hasil karakterisasi nanosuspensi formula optimum: potensial zeta +47,7; efisiensi penjerapan 63,49% dan aktivitas antioksidan IC50, 30,22 bpj. Ekstrak kering dapat diformulasikan sebagai nanosuspensi antioksidan dan berpotensi dikembangkan sebagai sediaan oral.
Pembuatan, Karakterisasi, dan Optimasi Nanopartikel Gelasi Ionik Ekstrak Kering Rimpang Temulawak (Curcuma xanthorrhiza R.) menggunakan Rancangan Faktorial 22 Moch Futuchul Arifin; Yuslia Noviani; Safira Nafisa; Agisha Sheilabel
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1307

Abstract

Temulawak rhizome (Curcuma xanthorrhiza R.) is efficacious as antidiabetic because it has curcuminoid compounds. The aim of the research was to make, characterize, and optimize the nanoparticle formula of dried temulawak rhizome extract. The rhizomes were macerated using 96% ethanol. The curcuminoid content of the thick extract was determined using a spectrophotometer and dried extract using a spray dryer. The dried extract was formulated into nanosuspension using ionic gelation method by mixing a concentration of 0.1–0.5% dried extract with a mixture of 0.2% chitosan and 0.1% sodium tripolyphosphate in a 2:1–5:1 ratio. Characterization was carried out including: particle morphology, particle size, polydispersity index, zeta potential, and entrapment efficiency. Response data were analyzed by factorial 22 design using Minitab18 software to determine the optimum formula. The concentration of curcuminoids in the thick extract was 15.96%. The morphology of the nanosuspension was spherical, with a particle size of 114.7–399.3 nm, a polydispersity index of 0.429–0.597, a zeta potential of 35.1–48.6 mV, and an entrapment efficiency of 61.08–73.37%. The optimum formula was obtained with a composition of 0.44% extract and chitosan: Na-TPP (2:1) with a desirability value, d= 0.8984. It can be concluded that the factorial design of 22 can be used to determine the optimum formula for dried extract of temulawak rhizome using the ionic gelation method.
Nanosuspension Formula of Curcuma xanthorriza Rhizome Dry Extract: Impact of Tween 80-PEG 400 Ratio Arifin, Moch Futuchul; Shafira, Elza; Noviani, Yuslia; Desmiaty, Yesi; Okta, Fauzia Noprima
Sciences of Pharmacy Volume 3 Issue 2
Publisher : ETFLIN Publishing House

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58920/sciphar0302222

Abstract

Our previous research investigated nanosuspension using the ionic gelation method with a 2:1 ratio of chitosan to sodium tripolyphosphate (TPP) and 0.44% Curcuma xanthorriza rhizome extract. The results indicated an unstable nanosuspension with a particle size of 399.3 nm, a polydispersity index of 0.60, and an entrapment efficiency of 73.37%. This study aims to develop a nanosuspension using Tween 80-PEG 400 to improve the characteristics and dissolution at pH 6.8. Curcuma rhizome was macerated with 96% ethanol and dried using a spray dryer. The nanosuspension formulation was designed using a 22 factorial design with Tween 80 (0.1%-0.4%) and PEG 400 (0.1%-0.4%) as factors, and the formulation was analyzed using Minitab 18. The dissolution of the optimum formulation was tested. The best formulation, comprising 0.1% Tween 80 and 0.4% PEG 400, provided a spherical shape, a particle size of 111.26 nm, a polydispersity index of 0.27, a zeta potential of 30.77 mV, an entrapment efficiency of 84.30%, and a desirability value of 0.9058. The release of curcumin at pH 6.8 after 180 minutes was 37.85% ± 0.1375 with a DE180 of 83.60% ± 0.1457. The 22 factorial design proved effective for enhancing formulation attributes. Based on the result obtained, it can be concluded that the best formulation contains 0.1% Tween 80 and 0.4% PEG 400, with zero-order release kinetics and a diffusion mechanism.
Co-Authors Agisha Sheilabel Anarisa Budiati Bagus Bahtiar Calista Nathania Dian Ratih Laksmitawati DIANA SYARMALINA DIDA MAULIDA HASANAH HIFZIEL AZHAR Isnaini Hidayanti LILIEK NUR HIDAYATI Liliek Nurhidayati Noviani, Yuslia Okta, Fauzia Noprima RENSY RENSY Safira Nafisa SHAFA NABILAH Shafira, Elza Syarmalina Syarmalina Yesi Desmiaty, Yesi YUSLIA NOVIANI Yuslia Noviani