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All Journal Buletin Farmatera Jurnal Ilmu Kefarmasian Indonesia Sumatera Medical Journal International Journal Of Science, Technology & Management (IJSTM)
Tri Widyawati
Department Of Pharmacology & Therapeutic, Faculty Of Medicine, Universitas Sumatera Utara
Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mechanical Engineering Medicine & Pharmacology Public Health Transportation

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Efek Antibakteri Kombinasi Ekstrak Daun Kelor (Moringa oleifera Lam.) dan Amoksisilin terhadap Staphylococcus aureus dan Escherichia coli secara In Vitro Setiadi Abdillah Pratama; Tri Widyawati; Muhammad Ichwan; Dian Dwi Wahyuni
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1174

Abstract

Staphylococcus aureus and Escherichia coli often infect humans and risky cause antibiotics resistance including amoxicillin. This encourages us finding alternative active ingredients: Moringa oleifera leaf. This study evaluated antibacterial activity of combination of Moringa leaf extract (KDK) and amoxicillin (KA) against S. aureus and E. coli in vitro. The research methods with true experimental research with post-test control group design. KDK obtained by maceration. Four concentrations of KDK test materials (20, 30, 40, 50%) and 1 concentration of KA (3 mg/mL). Disc diffusion test method taken and the parameter measured: the diameter of the disc inhibition zone. Data analyzed by One-way ANOVA and further Tukey’s test. KDK+KA against S. aureus (20.77±1.79 – 21.33±1.74 mm)>KDK (11.45±0.21 – 12.45±0.28 mm) or KA (14.50±0.42 mm). KDK+KA against E. coli (15.53±0.71 – 17.87±0.42 mm)>KDK (9.00±0.28 – 10.30±0.42 mm) or KA (13.45±0.35 mm). A significant (p<0.05) was obtained between the combination group (KDK+KA) versus a group (KDK or KA). The combination of Moringa leaf ethanol extract and amoxicillin synergistically effected as antibacterial against S. aureus and E. coli in vitro.
Yield Analysis and Phytochemical Screening of Ethanol Extract of Phaleria macrocarpa Leaves Ira Cinta Lestari; Dharma Lindarto; Syafruddin Ilyas; Tri Widyawati; Suryani Eka Mustika
Buletin Farmatera Vol 8, No 1 (2023)
Publisher : Universitas Muhammadiyah Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30596/bf.v8i1.11724

Abstract

Phaleria macrocarpa leaves have the potential to be used as raw materials for medicines derived from natural ingredients, but research is needed to determine the content and efficacy of these plants. This study aims to analyze the yield and screening of the content of phytochemical compounds in the ethanolic extract of the Phaleria macrocarpa leaves. This research is a descriptive study. Extract yield analysis was performed by calculating the weight ratio of the extract divided by the simplicia multiplied by one hundred percent. Screening for the phytochemical content was carried out for compounds belonging to the class of flavonoids, saponins, tannins, alkaloids, steroids, and triterpenoids. The results of the calculation of the yield of the extract obtained were 14.58% and the results of the phytochemical test showed that the extract contained flavonoids, alkaloids, tannins, glycosides, saponins, and steroids.
The Effect of Dendrophthoe pentandra (L.) Miq Ethanol Extract on Malondialdehyde (MDA) in Hyperglycemic Rats Anggun Syafitri; Yuandani Yuandani; Tri Widyawati
International Journal of Science, Technology & Management Vol. 4 No. 2 (2023): March 2023
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v4i2.758

Abstract

Dendrophthoe pentandra (L.) Miq is a parasitic plant with medicinal potential found in 3000 other plant species. The duku parasite is usually considered a parasite on the duku plant and is often discarded because it is thought to interfere with the growth of the duku plant. The purpose of this study was to see the effect of the duku parasite leaf extract on the reduction of malondialdehyde (MDA) in hyperglycemic rats. MDA levels were measured by thiobarbituric acid-reactive substance (TBARS) assay with doses of duku mistletoe leaf ethanol extract of 400, 200, and 100 mg/kg BW. MDA levels were analysed using rat blood plasma, which was measured using a spectrophotometer at a wavelength of 532 nm. Oral administration of EEDBD 400, 200, and 100 mg/kg BW reduced MDA levels in hyperglycemic rats. However, only EEDBD 400 mg/kg BW showed a significant difference between the negative control (CMC-Na), but with glibenclamide and the normal groups, there was no significant difference.
The Effect of Ethanol Extract of Grape (Vitis vinifera) as an Anti-Aging for Women in Productive Age Siti Nadhila; Tri Widyawati
Sumatera Medical Journal Vol. 4 No. 1 (2021): Sumatera Medical Journal (SUMEJ)
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/sumej.v4i1.3758

Abstract

Abstract. The aging process occurs in all parts of the body including the face. One of the factors that can influence this process is free radicals which can be suppressed by antioxidants. Grapes (Vitis vinifera) are known to contain high antioxidant compounds. This research was conducted to determine the anti-aging activity of grape ethanol extract (V. vinifera) in clay mask preparations. Grape ethanol extract obtained by maceration and formulated in clay mask dosage form with 4 concentrations namely FI (2.5%), FII (5%), FIII (7.5%) and F0 as a control. A total of 12 volunteers who met the inclusion criteria were applied to the mask every week for 4 weeks and evaluated the water content, smoothness, large pores, many blemishes and facial skin wrinkles before and after application in each treatment. Mask stability was evaluated for 12 weeks at room temperature. Data were analyzed by the Kruskal Wallis and Friedman tests. After 4 weeks of treatment, the highest changes including humidity (12.63%), pore size (50%), blemishes (57.32%) and wrinkles (75.69%) were found in FIII. While changes in skin smoothness were found in FII by 34.04%. There was a significant moisture difference between F0-FIII (p <0.05), a significant difference in evenness between F0-FI, F0-FII and F0-FIII (p <0.05), a significant difference in spots between F0-FIII (p < 0.05) and significant differences in wrinkles between F0-FIII (p <0.05). Grape ethanol extract in clay mask preparations has anti-aging activity.
Co-Authors Anggun Syafitri Dharma Lindarto Ira Cinta Lestari Muhammad Ichwan Setiadi Abdillah Pratama Siti Nadhila Suryani Eka Mustika Syafruddin Ilyas Yuandani