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All Journal Jurnal Ilmu Kefarmasian Indonesia
Putu Monik Ananta Puspitarini
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

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Efek Antidiare Ekstrak Air Bunga Nagasari (Mesua Ferrea L.) Terhadap Mencit BALB/c yang Diinduksi Minyak Jarak Putu Monik Ananta Puspitarini; Iman Surya Pratama; Bambang Fajar Suryadi
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (342.297 KB) | DOI: 10.35814/jifi.v17i1.626

Abstract

Nagasari (Mesua ferrea L.) has a empirically repute for management of diarrhea in West Nusa Tenggara Province. However, the safety and efficacy of the nagasari flowers extract have not been scientifically validated in animal model. This study wasaimed to investigate the antidiarrheal effect of water extract of the nagasari flowers in BALB/c mice. The antidiarrhea activity of nagasari flowerswas investigated using castor oil-induced diarrhea increase in diarrhea index in mice.In castor oil-induced diarrhea test, mice received various consentrations of nagasari flowers extract (0,4% w/v; 0,8% w/v; and 1,6% w/v), where as negative controls received CMC-Na 1% and positive controls received loperamide 0,7 mg/kgBW orally once daily for 1 day and the mice droppings were observed. The phytochemical screening of nagasari flowers contain flavonoid, saponin, and phenolic. Water extract of nagasari flowers at concentration 1,6% showed significant inhibitory activity against castor oil-induced diarrhea when compared with positive controls (diarrhea index 0,083 ; p>0,05). Therefore, this study provides a scientific support for the acclaimed traditional use water extract of Mesua ferrea L. for the treatment of diarrheal diseases.
Co-Authors Iman Surya Pratama Suryadi, Bambang Fajar