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Efek Anti Diabetes Spirulina Platensis Terhadap Analisis Kadar, Gambaran Histopatologi, Ekspresi Insulin dan Glucose Transpoter 4 Pada Tikus Putih Wistar yang Diinduksi Streptozopin Kintoko Kintoko; Rifqi Ferry Balfas; Nura Ustrina; Sitarina Widyarini; Lintang Cahya Saputri; Anandita Nurwijayanti; Fajar Slamet Riana; Neni Tri Anggraini
JURNAL ILMU KEFARMASIAN INDONESIA Vol 16 No 2 (2018): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (331.578 KB) | DOI: 10.35814/jifi.v16i2.541

Abstract

Based on Basic Health Research, in Yogyakarta the incidence of diabetes mellitus based on doctor's diagnosis is 2.6% and symptoms will increase with age, but will decrease from age> 65 years. In the treatment of diabetes mellitus there are several treatments with synthetic drugs and natural ingredients for natural ingredients such as Spirulina platensis. Spirulina platensis is one of the microalgae that contains the natural spectrum of carotene and xantophyll pigment mixtures, and with fikocyanin has antioxidant activity, and Spirulina platensis can show a decrease in blood sugar. The type of research conducted is an experimental study. Spirulina platensis is made with several doses of 36 mg, 72 mg, and 144 mg. Rats were divided into 6 groups, 5 groups of streptozotosin induced at a dose of 45 mg / kgBW until the mice had DM were characterized by high KGD yield, then given spirulina suspension, measured in sugar levels on days 0-28. After that the mice in the blood and then analyzed the effect of Spirulina platensis on creatinine and urea in blood. The results were analyzed using SPSS ANOVA and Post Hoc Test methods with 95% confidence level. The results of the analysis of levels in various groups showed that in the induction of streptozotocin treated with spirulina plantesis various doses there was improvement in each analysis of the levels obtained, and also at the dose STZ+SP 36 in each analysis can improve the level of analysis. While on histopathology result and insulin expression in pancreas and histology and expression of glucose transporter 4 and histopathology on kidney and liver showed good change at various treatment dose group especially in STZ+SP 36 group. So at STZ+SP 36 dose showing the change both in this study.
IMPLEMENTASI KEBIJAKAN PENGELOLAAN PASAR INDUK (TERPADU) KOTA LHOKSEUMAWE Nura Ustrina; Aiyub; Ferizaldi, Ferizaldi; Nur Hafni
Jurnal PubBis Vol 8 No 2 (2024)
Publisher : stiatabalong.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35722/jurnalpubbis.v8i2.1036

Abstract

The current condition of the Integrated Central Market in Lhokseumawe City is highly concerning, with traders not occupying the market and parts of the building already damaged, despite the market being newly constructed under a multiyear scheme from the Lhokseumawe City regional budget starting in 2018. This study examines the management policies of the Integrated Central Market in Lhokseumawe City. The research method used is qualitative, with data sources obtained through observation, interviews, and documentation techniques. The data was analysed using descriptive analysis following the concept of Miles and Huberman with three steps of data analysis: data condensation, data display, and conclusion drawing/verification. The results of this study indicate that the management policies of the Integrated Central Market do not align with the initial planning design. The initial plan by the Lhokseumawe City government was to establish the building as a central market; however, it was later repurposed as a warehouse. The market management policies also fall short of the substance of the Minister of Trade's regulations concerning Guidelines and Development of Traditional Markets, Shopping Centres, and Modern Stores, and the absence of specific regional regulations has impeded the success of the policy. Issues such as policies deviating from the initial plans, the loss of resources and infrastructure, and a lack of communication between organisations and actors involved in carrying out their functions and duties have arisen due to an inadequate feasibility study. This has led to the market not being fully operational and being repurposed as a warehouse, when it should have been utilised for other, more productive activities that could contribute to the region, rather than becoming an abandoned or damaged building. Keywords: Implementation, Policy, Market Management