Article Per Year (5 Year)
p-Index From 2020 - 2025
1.037
P-Index
This Author published in this journals
All Journal Jurnal Ilmu Kefarmasian Indonesia Journal of Natural Product for Degenerative Diseases
Rika Sari Dewi
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
Evaluasi Keamanan dari Pengembangan Formula Nanopartikel Kurkumin pada Mencit dan Potensi Antioksidan In-VitroEvaluasi Keamanan dari Pengembangan Formula Nanopartikel Kurkumin pada Mencit dan Potensi Antioksidan In-Vitro Ni Made Dwi Sandhiutami; Rika Sari Dewi; Sondang Khairani; Sang Ayu Made Widyadari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1187

Abstract

Curcumin has various activities such as antioxidant, anti-inflammatory, antitumor, and antibacterial. The bioavailability of curcumin is low and needs to be optimized. The manufacture of curcumin nanoparticles with several solvents is one way to increase the bioavailability of curcumin. This study aims to examine the safety of curcumin nanoparticles through acute and subchronic toxicity tests and the antioxidant activity of the formula. Acute toxicity test was performed by OECD 425 method, using AOT425StatPgm device for the LD50. Subchronic toxicity test was carried out by OECD 407 method using 4 groups: normal, a dose of 50;100; and 200 mg/kg BW for 28 days, then evaluate body weight, clinical biochemistry, and hematology. An antioxidant activity test was carried out using DPPH. The results showed were the LD50 value of curcumin nanoparticles was>5000 mg/kg BW and the results of the subchronic toxicity test (p>0.05) did not show any significant differences in AST, ALT, BUN, creatinine, albumin, and hematology compare to the normal group. The IC50 of curcumin and curcumin nanoparticles were 118.76 µg/mL and 90.87 µg/mL, respectively. It can be concluded that curcumin nanoparticles are safe and do not affect kidney and liver function and the antioxidant activity of the curcumin nanoparticle formulation is greater than that of curcumin.
Efek Penurunan Kadar Glukosa Darah Rebusan Asparagus (Asparagus offi cinalis L.) Pada Mencit yang Diinduksi Aloksan Rika Sari Dewi; Lestari Rahayu; Ni Made Dwi Sandhiutami; Sondang Khairani; Isti Atika
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.956

Abstract

Diabetes mellitus characterized by hyperglycemia whereas the condition for high blood glucose. InIndonesia, there are a lot of medicinal plants that used as antidiabetic treatment. Medicinal plants are known have relatively few side eff ects compared to chemical based drugs. Asparagus (Asparagus offi cinalis L.) was reported to have fl avonoids and saponins compounds that could be functioned as antidiabetic. The aim of this research was to fi nd out the eff ect of boiled asparagus on blood glucose level in mice induced by Alloxan. This research used 30 male DDY strained mice, which were classifi ed into 6 groups, and each group consisted of 5 mice. These 6 groups were: normal control, negative control, positive control (Acarbose), the boiled asparagus with dose of 280, 560, and 840 mg/kgBW for 14 days. Blood glucose level of mice were observed on day-0, 8, 15, and 22. The results showed that Alloxan injection increased the level of blood glucose. Another result showed that boiled asparagus with dose of 280, 560 and 840 mg/kgBW reduced the level of blood glucose and the eff ect showed treatment groups doses of 560 dan 840 mg/kgBW had no signifi cantly diff erent with positive control group (Acarbose).
Uji Efek Anti-Inflamasi dan Analgesik dari Rebusan Daun Bambu Kuning (Bambusa vulgaris Schard) Sondang Khairani; Lestari Rahayu; Ni Made Sandhiutami; Rika Sari Dewi; Ita Rahmawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.875

Abstract

Bamboo Kuning (Bambusa vulgaris Shard) leaves its efficacy as antioxidant, anti-inflammation, antidiabetic and antiulcer. The study aims to know volume edema decrease of rats foot as anti-inflammatory effect and the amount of strectching mice an analgesic effect the decoction of Bamboo Kuning. Anti-inflammatory test used Winter methods. Rats were be diveded into 5 groups: negative control be given aquadest, positive control be given sodium diclofenac 4,367 mg/200g BB, the test groups were given the decoction of Bamboo Kuning leaves 2,8 mL/200g BB with a concentration of 10%, 20% and 40%. Analgesic testing used methods Sigmund. Mice were divided into 5 groups: negative control be given aquadest, positive control were given sodium diclofenak 0,26 mg/20g BB, the test group was given the boiled of bamboo kuning leaves 0,4 mL/20g BB with concentration 10%, 20% and 40%. Statistic result decoction of leaves Bamboo Kuning dose 2,8 mL/200g BB with concentration 10%, 20% and 40% have anti-inflammatory and analgesic effect. Decoction of Bamboo Kuning leaves dose 2,8 mL/200g BB with concentration of 10%, 20% and 40% have anti-inflammatory and analgesic effect are lower than sodium diclofenac. Increased dose boiled of Bamboo Kuning leaves no provide increased effect as an anti-inflammatory and analgesic.
Anti-Inflammatory and Analgesic Effect from Decoction of Itchy Leaves (Laportea decumana (Roxb.) Wedd.) Khairani, Sondang; Rika Sari Dewi; Yeshika Krispansis Maelissa
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.7371

Abstract

Itchy leaves have the ability as analgesics, anti-inflammatory, asthma, antimalaria and antihypertension. Empirically in Maluku and Papua, itchy leaves are used topically to treat pain and inflammation. This study aims to examine the antiinflammatory and analgetic effects orally of an Itchy leaves decoction. Anti-inflammatory testing using the Winter method, rats were divided 5 groups negative control given aquadest, positive control given sodium diclofenac 1.8 mg/200 g BW rats, the test group given an infusion of itchy leaves dose 0.3 g/Kg BW (I), 0.6 g/Kg BW (I) and 1.2 g/Kg BW (III). Analgesics testing using Siegmund method, mice were divided 5 groups, negative control given aquadest, positive control given sodium diclofenac 0.26 mg/20 g BW mice, the test group given decoction of itchy leaves dose 0.4 g/Kg BW (I), 0.8 g/Kg BW (II) and 1.6 g/Kg BW (III). Results of Mann-whitney test, infusion of itchy leaves had a significant anti-inflammatory and analgesic effect on the negative control group, p value <0.05. Precentage of positive control edema inhibition and the test group dosage I, II, III was obtained by 27.94%; 15.97%; 25.89%; and 26.86%, percentage inhibition of positive control and the test group dosage I, II, III was obtained by 59.42%; 43.93%; 45.70% and 80.22%. Itchy leaves decoction has a lower anti-inflammatory effect than diclofenac sodium. The analgesics effect of decoction of Itchy leaves at doses of 0.4 g/Kg BW and 0.8 g/Kg BW was lower, dose of 1.6 g/Kg BW was higher than diclofenac sodium.
Anti-Inflammatory and Analgesic Effect: an Experimental Study of Purple Leaves (Graptophyllum pictum (L.) Griff) Decoction Sondang Khairani; Rika Sari Dewi; Yeshika Krispansis Maelissa
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 2 (2025): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i2.8421

Abstract

Purple leaves (Graptophyllum pictum (L.) Griff) are known to contain flavonoid compounds as anti-inflammatory and analgesic properties. This study aims to obtain the efficacy of purple leaf decoction as anti-inflammatory and analgesic. The anti-inflammatory study used the Winter method with Sprague Dawley rat test, were divided into 5 groups, negative control was only given aquadest, positive control with a dose of diclofenac sodium 8.0208 mg/200g BW, and 3 groups of decoction with doses of 5.4 mg/200g BW, 10.8 mg/200g BW and 21.6 mg/200g BW. Anti-inflammatory testing was carried out by measuring the decrease in the volume of edema on the soles of the rat's feet. Analgesic testing using the Siegmund method with Deutche Denken Yoken mice. The mice were divided into 5 groups, negative control was only given aquadest, positive control with a dose of diclofenac sodium 1.1586 mg/20g BW, and 3 groups of decoction with doses of 1 mg/20g BW, 2 mg/20g BW and 4 mg/20g BW. The analgesic study was carried out by calculating the decrease in the number of writhing mice. The results of the percentage of anti-inflammatory effectiveness of purple leaf decoction doses (5.4 mg/200g BW, 10.8 mg/200g BW and 21.6 mg/200g BW) were 51.77%, 68.77% and 79.46%, respectively. The results of the percentage of analgesic effectiveness of purple leaf decoction doses (1 mg/20g BW, 2 mg/20g BW and 4 mg/20g BW) were 54.03%, 71.62% and 79.73%, respectively. Based on the test results, it can be concluded that purple leaf decoction has an anti-inflammatory and analgesic effect.
Co-Authors Isti Atika Ita Rahmawati Lestari Rahayu Ni Made Dwi Sandhiutami S.Farm., M.Farm., Apt, Sondang Khairani Sang Ayu Made Widyadari Yeshika Krispansis Maelissa