Article Per Year (5 Year)
p-Index From 2020 - 2025
0.444
P-Index
This Author published in this journals
All Journal Journal of Natural Product for Degenerative Diseases
Yeshika Krispansis Maelissa
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Anti-Inflammatory and Analgesic Effect from Decoction of Itchy Leaves (Laportea decumana (Roxb.) Wedd.) Khairani, Sondang; Rika Sari Dewi; Yeshika Krispansis Maelissa
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 1 (2024): JNPDD September
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i1.7371

Abstract

Itchy leaves have the ability as analgesics, anti-inflammatory, asthma, antimalaria and antihypertension. Empirically in Maluku and Papua, itchy leaves are used topically to treat pain and inflammation. This study aims to examine the antiinflammatory and analgetic effects orally of an Itchy leaves decoction. Anti-inflammatory testing using the Winter method, rats were divided 5 groups negative control given aquadest, positive control given sodium diclofenac 1.8 mg/200 g BW rats, the test group given an infusion of itchy leaves dose 0.3 g/Kg BW (I), 0.6 g/Kg BW (I) and 1.2 g/Kg BW (III). Analgesics testing using Siegmund method, mice were divided 5 groups, negative control given aquadest, positive control given sodium diclofenac 0.26 mg/20 g BW mice, the test group given decoction of itchy leaves dose 0.4 g/Kg BW (I), 0.8 g/Kg BW (II) and 1.6 g/Kg BW (III). Results of Mann-whitney test, infusion of itchy leaves had a significant anti-inflammatory and analgesic effect on the negative control group, p value <0.05. Precentage of positive control edema inhibition and the test group dosage I, II, III was obtained by 27.94%; 15.97%; 25.89%; and 26.86%, percentage inhibition of positive control and the test group dosage I, II, III was obtained by 59.42%; 43.93%; 45.70% and 80.22%. Itchy leaves decoction has a lower anti-inflammatory effect than diclofenac sodium. The analgesics effect of decoction of Itchy leaves at doses of 0.4 g/Kg BW and 0.8 g/Kg BW was lower, dose of 1.6 g/Kg BW was higher than diclofenac sodium.
Anti-Inflammatory and Analgesic Effect: an Experimental Study of Purple Leaves (Graptophyllum pictum (L.) Griff) Decoction Sondang Khairani; Rika Sari Dewi; Yeshika Krispansis Maelissa
Journal of Natural Product for Degenerative Diseases Vol. 2 No. 2 (2025): JNPDD March
Publisher : Faculty of Pharmacy Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58511/jnpdd.v2i2.8421

Abstract

Purple leaves (Graptophyllum pictum (L.) Griff) are known to contain flavonoid compounds as anti-inflammatory and analgesic properties. This study aims to obtain the efficacy of purple leaf decoction as anti-inflammatory and analgesic. The anti-inflammatory study used the Winter method with Sprague Dawley rat test, were divided into 5 groups, negative control was only given aquadest, positive control with a dose of diclofenac sodium 8.0208 mg/200g BW, and 3 groups of decoction with doses of 5.4 mg/200g BW, 10.8 mg/200g BW and 21.6 mg/200g BW. Anti-inflammatory testing was carried out by measuring the decrease in the volume of edema on the soles of the rat's feet. Analgesic testing using the Siegmund method with Deutche Denken Yoken mice. The mice were divided into 5 groups, negative control was only given aquadest, positive control with a dose of diclofenac sodium 1.1586 mg/20g BW, and 3 groups of decoction with doses of 1 mg/20g BW, 2 mg/20g BW and 4 mg/20g BW. The analgesic study was carried out by calculating the decrease in the number of writhing mice. The results of the percentage of anti-inflammatory effectiveness of purple leaf decoction doses (5.4 mg/200g BW, 10.8 mg/200g BW and 21.6 mg/200g BW) were 51.77%, 68.77% and 79.46%, respectively. The results of the percentage of analgesic effectiveness of purple leaf decoction doses (1 mg/20g BW, 2 mg/20g BW and 4 mg/20g BW) were 54.03%, 71.62% and 79.73%, respectively. Based on the test results, it can be concluded that purple leaf decoction has an anti-inflammatory and analgesic effect.
Co-Authors Rika Sari Dewi S.Farm., M.Farm., Apt, Sondang Khairani