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All Journal Jurnal Farmasi Sains dan Komunitas Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Penelitian Farmasi Indonesia JSFK (Jurnal Sains Farmasi & Klinis) PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Ilmu Kefarmasian Indonesia Jurnal Pengabdian Masyarakat Indonesia Pharmaceutical And Biomedical Sciences Journal (PBSJ) Sciences of Pharmacy Borneo Journal of Pharmacy Journal of Natural Product for Degenerative Diseases Indonesian Journal of Administrative and Clinical Pharmacy

S.Farm., M.Farm., Apt, Sondang Khairani

Fakultas Farmasi Unniversitas Pancasila

Author-ID : 3682470

Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Education Engineering Environmental Science Health Professions Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology Public Health Social Sciences

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Edukasi dan Aplikasi Pengelolaan Sampah Berbasis Pemilahan Sampah di Lingkungan Fakultas Farmasi Universitas Pancasila Nurita Andayani; Esti Mulatsari; Moordiani Moordiani; Sondang Khairani; Gressty F Swandiny
Jurnal Abdimas BSI: Jurnal Pengabdian Kepada Masyarakat Vol 5, No 1 (2022): Februari 2022
Publisher : LPPM Universitas Bina Sarana Informatika

Fakultas Farmasi Universitas Pancasila (FFUP) merupakan salah satu fakultas yang ada di Universitas Pancasila yang memiliki jumlah mahasiswa cukup banyak. Selain itu, di Fakultas Farmasi Universitas Pancasila terdapat 9 kios kantin yang sehari-harinya melayani kebutuhan makanan dan minuman dari sivitas akademika FFUP serta fakultas lain di Universitas Pancasila yang berdampingan langsung dengan Fakultas Farmasi. Kondisi ini berpotensi menimbulkan suatu masalah yaitu penumpukan sampah. Secara umum kesadaran sivitas akademika dan orang-orang yang beraktivitas di lingkungan FFUP mengenai sampah masih kurang. Oleh karena itu edukasi, sosialisasi dan aplikasi mengenai pemilahan sampah sangat diperlukan di lingkungan FFUP yang berguna dalam mengurangi frekuensi sampah. Edukasi dan aplikasi telah dilakukan melalui kegiatan penyuluhan, pengadaan fasilitas pemilahan sampah, dan pelatihan aplikasi pemanfaatan sampah. Program ini cukup berhasil meningkatkan pengetahuan civitas akademika tentang pengelolaan sampah berbasis pemilahan sampah dengan kenaikan pemahaman dan kepedulian tentang pengelolaan sampah sebesar 4,58%, dan 8,94% secara berturut – turut dan telah diterapkan nya sistem pemilahan sampah di FFUP

Evaluasi Efek Samping OBat Kemoterapi terhadap Quality of Life (QOL) Pasien Kanker Payudara di Rumah Sakit X Jakarta Sondang Khairani; Sesilia A Keban; Meyke Afrianty
JURNAL ILMU KEFARMASIAN INDONESIA Vol 17 No 1 (2019): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Breast cancer is the number one cancer type discovered at women in the world. Most causes are genetic factors and hormonal factors. One cancer treatments with chemotherapy. Chemotherapy drugs active in cells dividing and reproducing, but cells normally to be affected by chemotherapy and side effects from chemotherapy drugs affect quality of life. The aim of the study to evaluate side effects of chemotherapy drugs on the quality of life of breast cancer patients. Sampling technique observational prospective breast cancer patients with completed the chemotherapy cycle from September 2017 to April 2018 with descriptive analysis and statistics by looking correlation between drug side effects and Quality of Life (QoL). Results of the study were side effects of fatigue 100%, nausea 67,5%, vomiting 60%, no appetite 63,75%, fever 42,5%, joint pain 43,75%, diarrhea 16,25%, difficulty swallowing 16,25%, allergies 5%, itching 1,25%, mouth sores 3,75%, swollen right hand 1,25%, constipation 3,75%. QoL results are physical 6,2%; psychology 5,3%; social 4,9%; spiritual 6,8%. Results of Sperman test showed no correlation between the side effects of chemotherapy and QoL P> 0,05. This study shows that there is no relationship between the side effects drug chemotherapy and QoL in breast cancer patients.

Pengaruh Pemberian Aspartam secara Oral terhadap Kadar AST dan ALT Serum serta Gambaran Histopatologi Hati Tikus Putih Ros Sumarny; Sondang Khairani; Mohamad Rega Satria Ramadhan
JURNAL ILMU KEFARMASIAN INDONESIA Vol 18 No 1 (2020): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Aspartame is low calorie sweetener metabolized into aspartic acid, phenylalanine and methanol, methanol cause damage to the liver. The purpose this study to determine the effect rats of oral aspartame administration for 90 days on biochemical parameters AST, ALT and liver histopathology. Rats were divided randomly into four groups: normal control, dose groups 126, 252, 504 mg/kgBW. Blood samples were taken on the 0th, 30th, 60th and 90th days to measure AST, ALT levels and 90th day to see liver histopathology. AST and ALT measurements using UV-VIS spectrophotometry with a wavelength of 340 nm. The levels of AST and ALT on the 90th day in the normal group 41,55 and 48,40 UI/L. Dose groups 126, 252, and 504 mg / kgBW were low doses 54,62 and 57,72 UI/L, 66,88 and 70,47 UI/L, 77,50 and 80,03 UI/L. Rats histopathology liver of aspartame showed hemorrhage. Concluded aspartame can increase of AST and ALT levels in rats blood serum and liver damage.

Evaluasi Keamanan dari Pengembangan Formula Nanopartikel Kurkumin pada Mencit dan Potensi Antioksidan In-VitroEvaluasi Keamanan dari Pengembangan Formula Nanopartikel Kurkumin pada Mencit dan Potensi Antioksidan In-Vitro Ni Made Dwi Sandhiutami; Rika Sari Dewi; Sondang Khairani; Sang Ayu Made Widyadari
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 1 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i1.1187

Curcumin has various activities such as antioxidant, anti-inflammatory, antitumor, and antibacterial. The bioavailability of curcumin is low and needs to be optimized. The manufacture of curcumin nanoparticles with several solvents is one way to increase the bioavailability of curcumin. This study aims to examine the safety of curcumin nanoparticles through acute and subchronic toxicity tests and the antioxidant activity of the formula. Acute toxicity test was performed by OECD 425 method, using AOT425StatPgm device for the LD50. Subchronic toxicity test was carried out by OECD 407 method using 4 groups: normal, a dose of 50;100; and 200 mg/kg BW for 28 days, then evaluate body weight, clinical biochemistry, and hematology. An antioxidant activity test was carried out using DPPH. The results showed were the LD50 value of curcumin nanoparticles was>5000 mg/kg BW and the results of the subchronic toxicity test (p>0.05) did not show any significant differences in AST, ALT, BUN, creatinine, albumin, and hematology compare to the normal group. The IC50 of curcumin and curcumin nanoparticles were 118.76 µg/mL and 90.87 µg/mL, respectively. It can be concluded that curcumin nanoparticles are safe and do not affect kidney and liver function and the antioxidant activity of the curcumin nanoparticle formulation is greater than that of curcumin.

Efek Penurunan Kadar Glukosa Darah Rebusan Asparagus (Asparagus offi cinalis L.) Pada Mencit yang Diinduksi Aloksan Rika Sari Dewi; Lestari Rahayu; Ni Made Dwi Sandhiutami; Sondang Khairani; Isti Atika
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 1 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i1.956

Diabetes mellitus characterized by hyperglycemia whereas the condition for high blood glucose. InIndonesia, there are a lot of medicinal plants that used as antidiabetic treatment. Medicinal plants are known have relatively few side eff ects compared to chemical based drugs. Asparagus (Asparagus offi cinalis L.) was reported to have fl avonoids and saponins compounds that could be functioned as antidiabetic. The aim of this research was to fi nd out the eff ect of boiled asparagus on blood glucose level in mice induced by Alloxan. This research used 30 male DDY strained mice, which were classifi ed into 6 groups, and each group consisted of 5 mice. These 6 groups were: normal control, negative control, positive control (Acarbose), the boiled asparagus with dose of 280, 560, and 840 mg/kgBW for 14 days. Blood glucose level of mice were observed on day-0, 8, 15, and 22. The results showed that Alloxan injection increased the level of blood glucose. Another result showed that boiled asparagus with dose of 280, 560 and 840 mg/kgBW reduced the level of blood glucose and the eff ect showed treatment groups doses of 560 dan 840 mg/kgBW had no signifi cantly diff erent with positive control group (Acarbose).

Uji Efek Anti-Inflamasi dan Analgesik dari Rebusan Daun Bambu Kuning (Bambusa vulgaris Schard) Sondang Khairani; Lestari Rahayu; Ni Made Sandhiutami; Rika Sari Dewi; Ita Rahmawati
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.875

Bamboo Kuning (Bambusa vulgaris Shard) leaves its efficacy as antioxidant, anti-inflammation, antidiabetic and antiulcer. The study aims to know volume edema decrease of rats foot as anti-inflammatory effect and the amount of strectching mice an analgesic effect the decoction of Bamboo Kuning. Anti-inflammatory test used Winter methods. Rats were be diveded into 5 groups: negative control be given aquadest, positive control be given sodium diclofenac 4,367 mg/200g BB, the test groups were given the decoction of Bamboo Kuning leaves 2,8 mL/200g BB with a concentration of 10%, 20% and 40%. Analgesic testing used methods Sigmund. Mice were divided into 5 groups: negative control be given aquadest, positive control were given sodium diclofenak 0,26 mg/20g BB, the test group was given the boiled of bamboo kuning leaves 0,4 mL/20g BB with concentration 10%, 20% and 40%. Statistic result decoction of leaves Bamboo Kuning dose 2,8 mL/200g BB with concentration 10%, 20% and 40% have anti-inflammatory and analgesic effect. Decoction of Bamboo Kuning leaves dose 2,8 mL/200g BB with concentration of 10%, 20% and 40% have anti-inflammatory and analgesic effect are lower than sodium diclofenac. Increased dose boiled of Bamboo Kuning leaves no provide increased effect as an anti-inflammatory and analgesic.

Survei Rumah Tangga terhadap Profil Obat pada Responden dengan Jaminan Kesehatan Nasional di Jakarta Timur Mita Restinia; Yusi Anggriani; Sondang Khairani; Rulliani Bianca Wijaya
Jurnal Sains Farmasi & Klinis Vol 7, No 2 (2020): J Sains Farm Klin 7(2), Agustus 2020
Publisher : Fakultas Farmasi Universitas Andalas

Household surveys are one of the methods to obtain accurate information on medicine utilization in society. The study was carried out to identify the access of medicine and medicine utilization profile. A survey using convenient sampling method was conducted in 30 households with national health insurance (JKN) diagnosed with chronic diseases in East Jakarta. Each family was observed once a week for 8 weeks to analyse their diseases, medication used, and medicine access. About 19 (63.3%) respondents enrolled in this study were male. The mean ± SD of age was 55.87±12.486 years old. About 23(76.7%) respondent had access of medicine through hospital and 7(23.3%) by pharmacy directly. The most common chronic diseases identified were cardiovascular and endocrine disorder. Cardiovascular, alimentary tract and metabolism, and nervous system were medications most commonly used. Most of respondents used about 1-3 kind of medications in a month. About 101 kind of drugs used, 74 kinds of drug among of them were generic and 27 were non generic. About 12 (40%) respondents used vitamin and 8 (26.67%) used supplement. This study highlights respondent access of medicine through hospital and cardiovascular medicines were the most commonly used.

Evaluasi Switch Therapy Antibiotik pada Pasien Apendisitis di RSUP Dr. M. Djamil Padang Sondang Khairani S.Farm., M.Farm., Apt
Jurnal Penelitian Farmasi Indonesia Vol. 7 No. 1: JPFI
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar

The way to optimize antibiotic therapy is to immediately replace intravenous therapy to oral (switch therapy). Intravenous antibiotic therapy must be switched to an oral preparation or stopped after 48-72 hours of injection, normal body temperature and normal white blood cell count. The purpose of this study is to evaluate antibiotic selection and timeliness for switch therapy. The sampling technique all patients hospitalized with appendicitis at surgical department Dr. M. Djamil Padang, from September until November 2013 received switch therapy, using a prospective observation study design with descriptive analysis. Results showed that 36 patients entered the inclusion criteria. All use ceftriaxone intravenous, for oral antibiotics cefixime 25 patients, ciprofloxacin 11 patients. There were 8 patients on time when switching intravenous antibiotic therapy to oral. Switch therapy antibiotic almost on the third day of treatment 67%. The 36 patients studied had returned in improved clinical improvement and doctor’s approval.

Evaluasi Switch Therapy Antibiotik pada Pasien Pneumonia di RSUP Dr. M. Djamil Padang Sondang Khairani S.Farm., M.Farm., Apt
Jurnal Penelitian Farmasi Indonesia Vol. 4 No. 2 (2015): jpfi
Publisher : Lembaga Penelitian Sekolah Tinggi Ilmu Farmasi Jl. Kamboja Simpang Baru-Panam, Pekanbaru, Riau 28293 Telp. (0761) 588006, Fax. (0761) 588007 e-mail: editor-jpfi@stifar-riau.ac.id

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (203.285 KB)

The ideal route of administration for any medication is one that achieves serum concentration sufficient to produce the desired effect withoutproducing undesired effect. Patients may be concidered candidates for switching from intravenous to oral therapy once the patient has shown clinicalimprovement and is medically stable. Purpose of this study is the evaluation of selection antibiotics and timeliness to switch therapyfrom iv to oralantibiotics therapy.A prospective observation study, data were collected from all hospitalized patients with community-acquired pneumonia at internal medicinedepartment and respiratory care department at Dr. M. Djamil Public Hospital in Padang Indonesia from September until November 2013receivedantibioticswitchtherapy. Objective criteria were used to define time to switch therapy. Result showed, 49 patients fulfill inclusive criteria in thisresearch, 41 patients from internal medicine department and 8 patients from respiratory care department. All use ceftriaxone intravena, but 32 (65%)patients wrong in switched to oral therapy antibiotics, where 23 to cefixime, 7 to azithromycin, 1 to cefadroxyl and 1 to amoxcillin + clavulanic acid.Only 17 patients (35%) with prompt conversion of intravena antibiotic therapy to oral, 12 to ciprofloxacin and 5 to levofloxacin, only 12 patients rightin time to conversion intravena to oral antibiotics, with time to switch therapy was the fifth days. 49 patients have been discharged in goodconditionand doctor's approval.

Evaluasi Perencanaan dan Pengadaan Obat di Era Jaminan Kesehatan Nasional (JKN) di Puskesmas Kabupaten Cianjur Yusi Anggriani; Rina Rosdiana; Sondang Khairani
PHARMACY: Jurnal Farmasi Indonesia (Pharmaceutical Journal of Indonesia) Jurnal Pharmacy, Vol. 17 No. 02 Desember 2020
Publisher : Pharmacy Faculty, Universitas Muhammadiyah Purwokerto

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30595/pharmacy.v17i2.8673

Perencanaan diperlukan untuk menentukan jenis dan jumlah obat yang sesuai dengan kebutuhan. Pengadaan merupakan tahapan selanjutnya untuk merealisasikan kebutuhan obat, sehingga obat dapat tersedia dengan efektif dan efisien. Tujuan penelitian untuk mengetahui kesesuaian perencanaan dan pengadaan obat dengan rencana kebutuhan obat, e-catalogue dan Fornas di Puskesmas Kabupaten Cianjur. di Puskesmas Kabupaten Cianjur. Desain penelitian kuantitatif non eksperimental observasional. Data kuantitatif diambil secara retrospektif dari dokumen perenacanan, pengadaaan, dan laporan penggunaan obat di Puskesmas obat tahun 2019. Penelitian dilakukan di 23 Puskesmas yang disampling berdasarkan wilayah secara proporsional, dipilih berdasarkan tipe puskesmas dan jumlah kapitasi pertahun Hasil dari penelitian menunjukkan; rata-rata kesesuaian jenis obat di RKO dengan pengadaan obat sebesar 85,90%, kesesuaian jumlah obat di RKO dengan pengadaan sebesar 70,55%, kesesuaian antara pengadaan obat dengan Fornas sebesar 77,01%. Kesesuaian dana obat yang terdapat dalam RKO dengan pengadaan obat sebesar 95,77%, alokasi dana pengadaan yang terserap sebesar 93,86%, alokasi dana obat sebesar 20,35% dari total dana pelayanan Kesehatan di Puskesmas. Pengadaan obat berdasarkan e-catalogue sistem sebesar 32,44%. Pengadaan obat di Puskesmas Kabupaten Cianjur belum sesuai dengan perencanaan, penggunaan dana JKN yang belum optimal, dan pengadaan obat berdasarkan e-catalogue masih perlu ditingkatkan.

Co-Authors Anggriani, Yusi Anita Rahmi Pradani Ariani, Lusiana Desi Nadya Aulena Erna Kristin Fauzia Noprima Okta Fitri Nurhayati Gressty F Swandiny Hesty Utami Ramadaniati Hesty Utami Ramadaniati Ika Permata Sari Ira Ningtiyas Purpranoto Isti Atika Ita Rahmawati Kurnia, Mala Lestari Rahayu Manninda, Reise Manninda, Reise Meyke Afrianty Mita Restinia Mohamad Rega Satria Ramadhan Moordiani Moordiani Mulatsari, Esti Ni Made Dwi Sandhiutami Nurita Andayani Nurul Azizah Prih Sarnianto Raharjo, Lalu Joko Reise Manninda RIKA SARI DEWI Rika Sari Dewi Rina Rosdiana Ros Sumarny ROS SUMARNY Rulliani Bianca Wijaya Safira Nafisa Sang Ayu Made Widyadari Sarah, Mutia Sesilia A Keban Shirly Kumala Wanda Ditan Arvandi Widodo, Akhmad Fajri Wijaya, Rulliani Bianca Wijayanti, Bitya Aulia Yeshika Krispansis Maelissa Yurista Elystra Yusi Anggriani Yusi Anggriani Zainur Rahman Hakim

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