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All Journal Jurnal Ilmu Kefarmasian Indonesia Sainstech Farma: Jurnal Ilmu Kefarmasian
Yuslia Noviani
Fakultas Farmasi, Universitas Pancasila
Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Formulasi dan Uji Antibakteri Sediaan Gel Ekstrak Kelopak Bunga Rosela (Hibiscus sabdariffa L.) terhadap Pseudomonas aeruginosa dan Propionibacterium acnes Safira Nafisa; Yuslia Noviani; Moch Futuchul Arifin; Calista Nathania
SAINSTECH FARMA Vol 14 No 1 (2021): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v14i1.933

Abstract

Kelopak bunga rosela (Hibiscus sabdariffa L.) diketahui memiliki aktivitas antibakteri terhadap Pseudomonas aeruginosa dan Propionibacterium acnes. Aktivitas tersebut diduga karena adanya senyawa alkaloid, flavonoid, tanin, dan saponin yang terkandung dalam bunga rosela. Tujuan penelitian ini adalah mendapatkan formula optimum dari sediaan gel ekstrak kelopak bunga rosela yang baik secara fisik, kimia, dan efektivitasnya sebagai antibakteri. Metode yang digunakan adalah rancangan faktorial 23 dengan 3 faktor, yaitu Konsentrasi Hambat Minimum (KHM) ekstrak kelopak bunga rosela (6 dan 12%), carbomer 940 (1,5 dan 2,0%), dan propilenglikol (10 dan 15%). Sediaan gel dievaluasi mutu fisik, kimia, dan efektivitas secara in vitro, kemudian dianalisis menggunakan program Minitab 17 untuk mengetahui pengaruh faktor dan interaksinya terhadap respon yang dihasilkan. Hasil uji fisik sediaan gel yaitu berbentuk semisolid; berwarna coklat; berbau khas rosela; dengan viskositas 19375 – 68750 cPs; pH 4,42 – 5,53; daya sebar 18,39 – 31, 08 cm2; diameter daerah hambat Pseudomonas aeruginosa 10,88 – 14,88 mm; dan diameter daerah hambat Propionibacterium acnes 10,63 – 13,88 mm. Pada penelitian ini diperoleh formula optimum yaitu konsentrasi ekstrak 10.18%, carbomer 940 2%, propilenglikol 15%, trietanolamin 2%, natrium benzoat 0,1%, dan air suling ad 100%. Berdasarkan hal tersebut dapat disimpulkan bahwa sediaan gel yang mengandung ekstrak kering kelopak bunga rosela baik secara fisik dan kimia, serta mampu menghambat pertumbuhan bakteri Pseudomonas aeruginosa dan Propionibacterium acnes.
Pembuatan, Karakterisasi, dan Optimasi Nanopartikel Gelasi Ionik Ekstrak Kering Rimpang Temulawak (Curcuma xanthorrhiza R.) menggunakan Rancangan Faktorial 22 Moch Futuchul Arifin; Yuslia Noviani; Safira Nafisa; Agisha Sheilabel
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1307

Abstract

Temulawak rhizome (Curcuma xanthorrhiza R.) is efficacious as antidiabetic because it has curcuminoid compounds. The aim of the research was to make, characterize, and optimize the nanoparticle formula of dried temulawak rhizome extract. The rhizomes were macerated using 96% ethanol. The curcuminoid content of the thick extract was determined using a spectrophotometer and dried extract using a spray dryer. The dried extract was formulated into nanosuspension using ionic gelation method by mixing a concentration of 0.1–0.5% dried extract with a mixture of 0.2% chitosan and 0.1% sodium tripolyphosphate in a 2:1–5:1 ratio. Characterization was carried out including: particle morphology, particle size, polydispersity index, zeta potential, and entrapment efficiency. Response data were analyzed by factorial 22 design using Minitab18 software to determine the optimum formula. The concentration of curcuminoids in the thick extract was 15.96%. The morphology of the nanosuspension was spherical, with a particle size of 114.7–399.3 nm, a polydispersity index of 0.429–0.597, a zeta potential of 35.1–48.6 mV, and an entrapment efficiency of 61.08–73.37%. The optimum formula was obtained with a composition of 0.44% extract and chitosan: Na-TPP (2:1) with a desirability value, d= 0.8984. It can be concluded that the factorial design of 22 can be used to determine the optimum formula for dried extract of temulawak rhizome using the ionic gelation method.
Co-Authors Agisha Sheilabel Calista Nathania Moch Futuchul Arifin Safira Nafisa