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All Journal JFIOnline Jurnal Ilmu Kefarmasian Indonesia SULUH: Jurnal Abdimas Jurnal Ilmiah Farmako Bahari Sainstech Farma: Jurnal Ilmu Kefarmasian Interdisciplinary Social Studies Jurnal Farmasi Indonesia

Safira Nafisa

Fakultas Farmasi Universitas Pancasila

Author-ID : 3683853

Biochemistry, Genetics & Molecular Biology Chemistry Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Public Health Social Sciences Other

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Formulasi Sediaan Tablet Kunyah Kompleks Inklusi Dimenhidrinat–β-Siklodekstrin dengan Metode Pengeringan Semprot (Chewable Tablet from Inclusion Complexes of Dimenhydrinate– β-Cyclodextrine using Spray Drying Method) Faizatun, Faizatun; Joenoes, Luvita; Nafisa, Safira
Jurnal Farmasi Indonesia Vol 11, No 1 (2019)
Publisher : Indonesian Research Gateway

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i1.593

Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality. Taste becomes an important parameter in the delivery of a chewable tablet, primarily aimed for childrens. The purpose of this study is to mask the bitter taste and create dimenhydrinate chewable tabletas motion sickness drug that meet the physical and chemical quality. The method used to mask the bitter taste of dimenhydrinate is inclusion complexes with β-cyclodextrin in spray drying. Inclusion complex powders evaluation included flowcity and water content, and characterized by infrared spectrophotometry and DSC (Differential Scanning Calorimetry). Inclusion complex powders was made into chewable tablet with direct compression method. Chewable tablet was evaluated including tablets concentration (94.33-106,47%), the diversity of weights (85-115%), tablets diameter (1.013 cm), tablets thickness (0.49 cm), hardness (3.75-4.58 kg/cm2), friability (2,98-3,42%,). Dimenhydrinate chewable tablet taste test were statistically analyzed with non-parametric Kruskal-Wallis which results a significant differences of the bitter taste that masked among the five molar concentration differences of dimenhydrinate and β-cyclodextrine. The higher molar ratio of β-cyclodextrin (0,5-3) used, has the better result for masking the bitterness of dimenhydrinate. The used of β-cyclodextrin with the ratio in five molar concentration differences can not optimally mask the bitter taste of dimenhydrinate. Chewable tablet of formula IV has met the best physical and chemical quality.

PENGARUH PENGISI HASIL SPRAY DRYING TERHADAP KARAKTERISTIK ORALLY DISINTEGRATING TABLET (ODT) FAMOTIDIN Faizatun, Faizatun; Saputra, Andreas Agung; Nafisa, Safira
Jurnal Farmasi Indonesia Vol 11, No 2 (2019)
Publisher : Jurnal Farmasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35617/jfi.v11i2.669

Famotidine is used in the treatment of gastric disease and required rapid action of drugs in application. Orally Disintegrating Tablet (ODT) dosage has a fast disintegration time, caused therapeutic effects of famotidine could occur immediately. In this study, a characteristics of ODT comparison is made with ODT diluent with spray drying methods and comparative diluent in the market. ODT diluent consisted of Avicel PH 102, xylitol, mannitol, and crospovidone (2, 3.5, 5%). ODT diluent is used for the manufacture of ODT tablets with direct compresstion method. Evaluation of diluent consisted of water content, flowcity, and compressibility test, while evaluation of ODT tablets consisted of disintegration time, dissolution, hardness, and friability to see the effect of differences crospovidone concentration. Based on the result, F III with 5% crospovidone concentration had a faster disintegration time (44.45 seconds), smaller hardness (5.68 kg / cm2) and greater friability (0.46%) than F I and F II tablets. F III tablet has a longer disintegration time (44.45 seconds) than comparable ODT tablets (33 seconds).

Penapisan Fitokimia dan Uji Aktivitas Antimikroba Ekstrak Etanol Daun Jeruk Nipis (Citrus Aurantifolia) Safira Nafisa; Greesty Finotory Swandiny; Erlindha Gangga; Yulianita Ariefiyanty Zaenudin
JURNAL ILMU KEFARMASIAN INDONESIA Vol 19 No 2 (2021): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v19i2.1095

Jeruk nipis (Citrus aurantifolia S.) merupakan salah satu tanaman obat tradisional yang digunakan secara luas untuk berbagai penyakit termasuk infeksi. Penelitian ini bertujuan untuk menguji aktivitas ekstrak etanol 70% dan 96% daun Citrus aurantifolia terhadap mikroba penyebab infeksi pada manusia, antara lain Staphylococcus aureus, Salmonella typhi, Escherichia coli, dan Candida albicans secara in vitro. Penapisan fitokimia dilakukan untuk memprediksi metabolit sekunder yang berperan dalam aktivitas antimikroba daun Citrus aurantifolia. Aktivitas antimikroba ditentukan menCitrus aurantifolia S. is a traditional medicinal plant that is widely used for various diseases including infections. This study aims to test the in vitro antimicrobial activity of 70% and 96% ethanolic extract of Citrus aurantifolia leaves to microbes that cause infection in humans, including Staphylococcus aureus, Salmonella typhi, Escherichia coli, and Candida albicans. Phytochemical screening was carried out to predict secondary metabolites that play a role in the antimicrobial activity of Citrus aurantifolia leaves. The antimicrobial activity was determined using agar diffusion method with disc paper and well diffusion method. Phytochemical screening showed that simplicia powder, 70% ethanol extract, and 96% ethanol extract from Citrus aurantifolia leaves contained flavonoids, coumarin, saponins, tannins, steroids / triterpenoids, and essential oils. This study showed that 70% and 96% ethanol extract of Citrus aurantifolia leaves can inhibit the growth of Staphylococcus aureus, Salmonella typhi, and Escherichia coli bacteria. It can be concluded that the ethanol extract of Citrus aurantifolia leaves is potential to be developed as an antibacterial product.ggunakan metode difusi agar dengan kertas cakram dan metode difusi sumuran. Penapisan fitokimia menunjukkan bahwa baik serbuk simplisia, ekstrak etanol 70%, dan ekstrak etanol 96% dari daun Citrus aurantifolia mengandung metabolit sekunder flavonoid, kumarin, saponin, tanin, steroid/triterpenoid, dan minyak atsiri. Ekstrak etanol 70% dan 96% daun Citrus aurantifolia dapat menghambat pertumbuhan bakteri Staphylococcus aureus, Salmonella typhi, dan Escherichia coli. Dengan demikian dapat disimpulkan ekstrak etanol daun Citrus aurantifolia berpotensi dikembangkan sebagai produk antibakteri.

Formulasi dan Uji Antibakteri Sediaan Gel Ekstrak Kelopak Bunga Rosela (Hibiscus sabdariffa L.) terhadap Pseudomonas aeruginosa dan Propionibacterium acnes Safira Nafisa; Yuslia Noviani; Moch Futuchul Arifin; Calista Nathania
SAINSTECH FARMA Vol 14 No 1 (2021): Sainstech Farma: Jurnal Ilmu Kefarmasian
Publisher : FAKULTAS FARMASI, INSTITUT SAINS DAN TEKNOLOGI NASIONAL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37277/sfj.v14i1.933

Kelopak bunga rosela (Hibiscus sabdariffa L.) diketahui memiliki aktivitas antibakteri terhadap Pseudomonas aeruginosa dan Propionibacterium acnes. Aktivitas tersebut diduga karena adanya senyawa alkaloid, flavonoid, tanin, dan saponin yang terkandung dalam bunga rosela. Tujuan penelitian ini adalah mendapatkan formula optimum dari sediaan gel ekstrak kelopak bunga rosela yang baik secara fisik, kimia, dan efektivitasnya sebagai antibakteri. Metode yang digunakan adalah rancangan faktorial 23 dengan 3 faktor, yaitu Konsentrasi Hambat Minimum (KHM) ekstrak kelopak bunga rosela (6 dan 12%), carbomer 940 (1,5 dan 2,0%), dan propilenglikol (10 dan 15%). Sediaan gel dievaluasi mutu fisik, kimia, dan efektivitas secara in vitro, kemudian dianalisis menggunakan program Minitab 17 untuk mengetahui pengaruh faktor dan interaksinya terhadap respon yang dihasilkan. Hasil uji fisik sediaan gel yaitu berbentuk semisolid; berwarna coklat; berbau khas rosela; dengan viskositas 19375 – 68750 cPs; pH 4,42 – 5,53; daya sebar 18,39 – 31, 08 cm2; diameter daerah hambat Pseudomonas aeruginosa 10,88 – 14,88 mm; dan diameter daerah hambat Propionibacterium acnes 10,63 – 13,88 mm. Pada penelitian ini diperoleh formula optimum yaitu konsentrasi ekstrak 10.18%, carbomer 940 2%, propilenglikol 15%, trietanolamin 2%, natrium benzoat 0,1%, dan air suling ad 100%. Berdasarkan hal tersebut dapat disimpulkan bahwa sediaan gel yang mengandung ekstrak kering kelopak bunga rosela baik secara fisik dan kimia, serta mampu menghambat pertumbuhan bakteri Pseudomonas aeruginosa dan Propionibacterium acnes.

FORMULASI DAN UJI AKTIVITAS ANTIOKSIDAN EMULGEL EKSTRAK KULIT BUAH KAKAO (Theobroma cacao L.) Safira Nafisa; Fahleni Fahleni; Nadilla Salsabilla
Jurnal Ilmiah Farmako Bahari Vol 12, No 2 (2021): Jurnal Ilmiah Farmako Bahari
Publisher : Fakultas MIPA Universitas Garut

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52434/jfb.v12i2.1158

Kulit buah kakao (Theobroma cacao L.) mengandung sejumlah besar polifenol dan flavonoid yang dapat berfungsi sebagai antioksidan untuk mencegah penuaan dini. Penelitian ini bertujuan untuk memperoleh sediaan emulgel dari ekstrak kulit buah kakao yang memiliki aktivitas antioksidan. Ekstrak kental kulit buah kakao dibuat dengan metode maserasi kinetik menggunakan etanol 70% yang dipekatkan menggunakan rotary vacuum evaporator. Aktivitas antioksidan ekstrak diuji menggunakan metode DPPH. Ekstrak kemudian diformulasikan ke dalam sediaan emulgel dengan metode emulsifikasi. Emulgel dievaluasi mutu fisik dan kimia meliputi organoleptik, homogenitas, viskositas dan sifat alir, tipe emulsi, kemampuan menyebar, sentrifugasi, pH, freeze thaw, dan uji aktivitas antioksidan. Hasil penelitian menunjukkan ekstrak kulit buah kakao memiliki nilai IC50 sebesar 10,03 ± 0,43 bpj. Emulgel formula terbaik yang dihasilkan berbentuk semi padat, homogen, berwarna coklat dan beraroma khas coklat dengan nilai IC50 sebesar 143,12 ± 5,32 bpj. Dengan demikian dapat disimpulkan formula emulgel ekstrak kulit buah kakao berpotensi dikembangkan sebagai sediaan antioksidan. Kata kunci: antioksidan, emulgel, kulit buah kakao

Pembuatan, Karakterisasi, dan Optimasi Nanopartikel Gelasi Ionik Ekstrak Kering Rimpang Temulawak (Curcuma xanthorrhiza R.) menggunakan Rancangan Faktorial 22 Moch Futuchul Arifin; Yuslia Noviani; Safira Nafisa; Agisha Sheilabel
JURNAL ILMU KEFARMASIAN INDONESIA Vol 20 No 2 (2022): JIFI
Publisher : Fakultas Farmasi Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v20i2.1307

Temulawak rhizome (Curcuma xanthorrhiza R.) is efficacious as antidiabetic because it has curcuminoid compounds. The aim of the research was to make, characterize, and optimize the nanoparticle formula of dried temulawak rhizome extract. The rhizomes were macerated using 96% ethanol. The curcuminoid content of the thick extract was determined using a spectrophotometer and dried extract using a spray dryer. The dried extract was formulated into nanosuspension using ionic gelation method by mixing a concentration of 0.1–0.5% dried extract with a mixture of 0.2% chitosan and 0.1% sodium tripolyphosphate in a 2:1–5:1 ratio. Characterization was carried out including: particle morphology, particle size, polydispersity index, zeta potential, and entrapment efficiency. Response data were analyzed by factorial 22 design using Minitab18 software to determine the optimum formula. The concentration of curcuminoids in the thick extract was 15.96%. The morphology of the nanosuspension was spherical, with a particle size of 114.7–399.3 nm, a polydispersity index of 0.429–0.597, a zeta potential of 35.1–48.6 mV, and an entrapment efficiency of 61.08–73.37%. The optimum formula was obtained with a composition of 0.44% extract and chitosan: Na-TPP (2:1) with a desirability value, d= 0.8984. It can be concluded that the factorial design of 22 can be used to determine the optimum formula for dried extract of temulawak rhizome using the ionic gelation method.

Pengaruh pengisi hasil Spray Drying terhadap karakteristik Orally Disintegrating Tablet (ODT) Famotidin Faizatun Faizatun; Andreas Agung Saputra; Safira Nafisa
JFIOnline | Print ISSN 1412-1107 | e-ISSN 2355-696X Vol. 11 No. 2 (2019): Jurnal Farmasi Indonesia
Publisher : Pengurus Pusat Ikatan Apoteker Indonesia

Famotidin digunakan dalam pengobatan penyakit lambung dan diperlukan waktu kerja obat yang cepat dalam penggunaan. Orally Disintegrating Tablet (ODT) merupakan suatu sediaan yang memiliki waktu hancur yang cepat, sehingga efek terapi dari famotidin dapat terjadi dengan segera. Pada penelitian ini, dilakukan perbandingan karakteristik ODT dengan pengisi ODT yang dibuat dengan metode spray drying dan pengisi pembanding yang terdapat dipasaran. Pengisi ODT yang dibuat terdiri dari avicel PH 102, xylitol, manitol, dan crospovidone ( 2; 3,5; 5%). Pengisi ODT yang dihasilkan digunakan untuk pembuatan tablet ODT secara cetak langsung. Evaluasi pengisi berupa uji sifat alir, kadar air, dan kompresibilitas, sedangkan evaluasi tablet ODT terdiri dari uji waktu hancur, disolusi, kekerasan, dan friabilitas untuk melihat pengaruh perbedaan konsentrasi crospovidone yang digunakan terhadap kecepatan hancurnya ODT. Hasil penelitian menunjukkan F III dengan konsentrasi crospovidone 5% dari tablet, memiliki waktu hancur lebih cepat (44,45 detik), kekerasan yang lebih kecil (5,68 kg/cm2) dan friabilitas yang besar (0,435%) dibandingkan tablet F I dan F II. Tablet F III memiliki waktu hancur yang lebih lama (44,45 detik) dari tablet ODT pembanding (33 detik).

PKM Pengembangan Usaha Desinfektan dan Antiseptik Berbahan Daun Bidara Pada Aspek Produksi dan E-Marketing Pratami, Diah Kartika; Saputra, Agung; Budiati, Anarisa; Nadya Aulena, Desi; Nafisa, Safira; Moordiani
SULUH: Jurnal Abdimas Vol 4 No 1 (2022): SULUH: Jurnal Abdimas Agustus
Publisher : FEB-UP Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/suluh.v4i1.3512

Tujuan kegiatan PKM membantu UKM yang memproduksi antiseptik dan desinfektan yang mengandung daun bidara dan serai wangi dalam permasalahan standardisasi produk, pemenuhan SNI, dan membuat sistem penjualan distributor/kegenan/reseller dengan memanfaatkan sistem teknologi informasi. Metode yang digunakan pemenuhan standard produk dengan pengujian potensi antimikroba produk di laboratorium FFUP. Kedua, membangun sistem teknologi informasi dengan membuatkan sistem informasi untuk kegiatan manajerial, distribusi dan pemasaran dengan metode less contact economy. Ketiga, melakukan pendampingan pembuatan konten produk untuk mengoptimalkan pemasaran online dan digital branding sebagai sarana komunikasi dengan target konsumennya. Hasil yang diperoleh UKM memperoleh sertifikat analisis produksi yang memenuhi standard mutu dan keamanan; dapat tercapai transfer knowledge metode produksi, pemastian mutu dan kualiti kontrol agar produk yang dihasilkan sesuai standard; terbentuknya sistem teknologi informasi dalam kegiatan manajerial, distribusi dan pemasaran produk yang bersifat less contact economy; serta tercapainya media online yang berisi konten edukasi kepada masyarakat. Luaran yang dihasilkan berupa prototipe produk yang telah memenuhi standard mutu dan keamanan sesuai regulasi Kemenkes, video kegiatan PKM di Youtube, pemberitaan di media massa, materi narasumber untuk digital branding, dan satu publikasi artikel ilmiah.

Red pomegranate (Punica granatum L.) peel extract mud mask formulation and tyrosinase-inhibition activity test Faizatun, Faizatun; Alfianita, Alfianita; Nafisa, Safira
JURNAL ILMU KEFARMASIAN INDONESIA Vol 22 No 1 (2024): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v22i1.1600

The peel of red pomegranates (Punica granatum L.) contains gallic acid and ellagic acid, which inhibit tyrosinase, an enzyme that aids melanin formation. This study aimed to determine how variations in the concentration of kaolin base affected the evaluation outcomes of mud mask formulations containing P. granatum fruit peel extract. P. granatum fruit peel extract was used in 3 formulas with variations in the kaolin base concentration of 19.5%, 22.5%, and 26.3%. The three formulations were subsequently evaluated through a series of procedures, which included organoleptic, homogeneity, spreadability, viscosity, pH measurements, and drying time. The enzyme-linked immunosorbent assay (ELISA) method was employed to determine the inhibitory activity of the tyrosinase enzyme. Formula 2 gives the best results with the characteristics of having a distinctive odor and thick brownish-green color, homogeneous preparation, spreadability of 20.5863 cm2, a viscosity of 16040 cPs; pH of 5.86, and drying time of 16.67 minutes. Inhibition of the tyrosinase enzyme by kojic acid, extracts, and preparations resulted in respective IC50 values of 31.64 μg/mL, 155.49 μg/mL, and 276.15 μg/mL. The results of the viscosity test, pH test, and mask drying time were significantly different as the concentration of the kaolin base varied (p<0.05).

Formulasi Nanosuspensi Herbal Ekstrak Daun Cosmos caudatus Kunth., Karakterisasi, dan Pendekatan Sitotoksisitas Terhadap Sel Kanker Payudara MCF-7 Nafisa, Safira; Noor, Siti Umrah; Azkannufuus, Azkannufuus; Noviani, Yuslia
JURNAL ILMU KEFARMASIAN INDONESIA Vol 21 No 2 (2023): JIFI
Publisher : Faculty of Pharmacy, Universitas Pancasila

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35814/jifi.v21i2.1481

Kenikir leaves (Cosmos caudatus Kunth.) contain quercetin, which has anticancer properties. To provide more effective complementary therapy for breast cancer, nanotechnology was applied to develop preparations containing kenikir leaf extract. This research aimed to formulate a nanosuspension containing kenikir leaf extract with cytotoxic activity against MCF-7 breast cancer cells. Nanosuspension of kenikir leaf extract was prepared using the ionic gelation method with 3%, 4%, and 5% PVP K-30 stabilizer. The nanosuspension formula with the highest entrapment efficiency was further characterised, including particle size, polydispersity index (PDI), zeta potential, pH, and particle morphology. Cytotoxic activity was tested against MCF-7 cells by the MTT assay. The results showed that the formula with 5% PVP has the highest entrapment efficiency value of 85.04±0.08%, a particle size of 221.9 nm, a PDI of 0.211, a zeta potential of -21.7 mV, a pH of 4.08±0.0, and a spherical morphology. The kenikir leaf extract at a concentration of 1 mg/mL inhibited the proliferation of MCF-7 cells by 23.4% (p<0.05), whereas the nanosuspension at 10 μg/mL inhibited proliferation by 23.7%. It can be concluded that kenikir leaf extract can be formulated into a nanosuspension that meets the physical criteria and has cytotoxic activity against MCF-7 cells.

Co-Authors Agisha Sheilabel Agung Saputra Alfianita, Alfianita Azkannufuus, Azkannufuus Bakhtiar, Muhammad Taher Budiati, Anarisa Calista Nathania Diah Kartika Pratami Erlindha Gangga Fahleni Fahleni Faizatun FAIZATUN, FAIZATUN Faizatun, Faizatun Greesty Finotory Swandiny Gumilar Adhi Nugroho Joenoes, Luvita Moch Futuchul Arifin Moordiani Moordiani Nadilla Salsabilla Nadya Aulena, Desi Noor, Siti Umrah Noviani, Yuslia Qodriah, Rahmatul RR. Ella Evrita Hestiandari Saputra, Andreas Agung Swandiny, Greesty Finotory Yulianita Ariefiyanty Zaenudin Yuslia Noviani

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