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All Journal Majalah Kedokteran Andalas
Sisca Dwi Yarni
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Health Professions Medicine & Pharmacology Public Health

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Correlation between Oxidative Stress with Cartilage Thickness and Catalase Activity in Osteoarthritis Model Rat after MSC-WJ Treatment Endrinaldi Endrinaldi; Rauza Sukma Rita; Tofrizal Tofrizal; Sisca Dwi Yarni
Majalah Kedokteran Andalas Vol 44, No 3 (2021): Online August 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i3.p%p.2021

Abstract

Objective: This study was conducted to investigate the involvement of oxidative damage in rat model of osteoarthritis treated with Mesenchymal Stem Cell Wharton Jelly and to elucidate whether oxidative stress indicators correlate with cartilage damage and catalase activity. Methods: This research is an experimental research with Posttest-Only Control Group Design. The sample consisted of 30 OA rat divided into 5 groups. Group I was the OA rat control group, group II was the OA rat group after 4 weeks, group III was the OA rat group after 8 weeks, group IV was the OA rat group after 4 weeks of treatment with MSC-WJ and group V is the OA rat group after 8 weeks treated with MSC-WJ. Malondialdehyde were measured by Ohkawa method, Cartilage Thickness were measured by using the Betaview program and catalase activity were measured by modification of Shinha.Results: The results showed that the analysis of the Correlation between MDA with Cartilage Thickness (r= – 0.665) and CAT activity (r= – 0.666) in osteoarthritis Model Rat after Mesenchymal Stem Cell Wharton’s Jelly Treatment.Conclusion: This study demonstrated a strong negative correlation between oxidative stress and knee cartilage thickness and catalase activity of MSC-WJ treated OA rats.
The Effect of Mesenchymal Stem Cell Wharton Jelly on Alzheimer’s Rat with Y-Maze Test Method Sisca Dwi Yarni; Hirowati Ali; Djong Hon Tjong
Majalah Kedokteran Andalas Vol 44, No 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i2.p112-116.2021

Abstract

Objective: This study aims to examine the y-maze test in alzheimer's rat after giving mesenchymal stem cell wharton jelly. Methods: This study used the y-maze test method to test the cognitive test of rat with the Y arm model. The treatment group consisted of a control, AlCl3, MSC-WJ and a combination of AlCl3 and MSC-WJ. The results obtained were analyzed in the form of a percentage. Results: The results of this study showed that the y-maze test showed that MSC-WJ had a significant effect compared to the AlCl3 control group in the alzheimer’s rat, namely 51.33% and 12.31%. Conclusion: In this study it was concluded that that MSC-WJ has a significant effect on alzheimer’s rat with y maze test.Keywords: AlCl3; Alzheimer’s; Mesenchymal Stem Cell Wharton Jelly
Efek Pemberian Mesenchymal Stem Cell Wharton's Jelly (MSC-WJ) terhadap Gambaran Histologi Pankreas Hewan Model Diabetes Melitus Tipe 1 Endrinaldi Endrinaldi; Tofrizal Tofrizal; Elmatris Elmatris; Sisca Dwi Yarni
Majalah Kedokteran Andalas Vol 46, No 10 (2024): Online May 2024
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v46.i10.p1704-1711.2024

Abstract

Objective: This study was conducted to determine the effect of administering Mesenchymal Stem Cell Wharton Jelly (MSC-WJ) on the histological appearance of the pancreas of rat in a type 1 diabetes mellitus model. Methods: This research is an experimental research with a Posttest-Only Control Group Design. The sample consisted of 3 groups (Normal, T1DM, T1DM + MSC-WJ). The treatment group was treated with MSC-WJ for 4 weeks. Data analysis used One Way ANOVA and Post Hoc Bonferroni tests. Results: WJ-MSC can increase the mean diameter and area of the islets of Langerhans in the T1DM rat group from 98.08 mm – 126.85 mm and from 4911.95 mm2 – 8995.35 mm2, but this difference is not yet significant (p > 0.05). Conclusion This research shows that there is improvement in pancreatic damage by administering WJ-MSC to diabetic rat due to alloxan induction.
Co-Authors Djong Hon Tjong Elmatris Elmatris Endrinaldi Hirowati Ali Rauza Sukma Rita Tofrizal