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Mellina Rahmi
Master Program in Biomedical Science, Faculty of Medicine, Universitas Andalas, Padang, Indonesia
Health Professions Medicine & Pharmacology Public Health

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Gambir Catechins (Uncaria gambir Roxb) Prevent Oxidative Stress in Wistar Male Rats Fed a High-Fat Diet Mellina Rahmi; Rauza Sukma Rita; Husna Yetti
Majalah Kedokteran Andalas Vol 44, No 7 (2021): Online Desember 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/mka.v44.i7.p436-441.2021

Abstract

Objective: This study aimed to examine how gambir catechins (Uncaria gambir Roxb) affect serum malondialdehyde (MDA) levels and catalase activity in Wistar white male rats fed a high-fat diet. Methods: This is a true experimental study with a post-test-only control group design. The experiment used 30 rats divided into five groups: a negative control group, a positive control group induced by a high-fat diet, and three treatment groups caused by a high-fat diet and given gambir catechins at doses of 10 mg/kg BW/day, 20 mg/kg BW/day, and 40 mg/kg BW/day for 14 days. The TBARs method measures MDA levels, while the colorimetry method measures catalase activity. One-way ANOVA and Post Hoc Tukey HSD are used to analyze the data. Results: The gambir catechin reduced serum MDA and increased catalase activity in male Wistar strain white rats fed a considerably high-fat diet (p<0.05). Conclusion: In mice fed a high-fat diet, catechin gambir was capable of dealing with oxidative damage.
Co-Authors Husna Yetti Rauza Sukma Rita