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All Journal SAINS MEDIKA : JURNAL KEDOKTERAN DAN KESEHATAN Jurnal Kedokteran Diponegoro Majalah Kedokteran Bandung Oto Rhino Laryngologica Indonesiana
Yanuar Iman Santosa
Departemen Ilmu Kesehatan THT-KL Fakultas Kedokteran Universitas Diponegoro Semarang
Health Professions Medicine & Pharmacology

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PENGARUH EKSTRAK KULIT MANGGIS (GARCINIA MANGOSTANA L.) TERHADAP JUMLAH KELAINAN HISTOPATOLOGI STRIA VASKULARIS KOKLEA PADA OTOTOKSISITAS (STUDI EKSPERIMENTAL PADA TIKUS WISTAR YANG DIINDUKSI GENTAMISIN) Fathoni, Mohammad Rifqi; Santosa, Yanuar Iman
DIPONEGORO MEDICAL JOURNAL (JURNAL KEDOKTERAN DIPONEGORO) Vol 7, No 2 (2018): JURNAL KEDOKTERAN DIPONEGORO
Publisher : Faculty of Medicine, Diponegoro University, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dmj.v7i2.20850

Abstract

Latar Belakang Gentamisin merupakan salah satu obat golongan aminoglikosida yang sangat luas penggunaannya. Namun, penggunaan obat gentamisin dapat menimbulkan efek samping berupa ototoksik, sehingga diperlukan upaya untuk mengurangi atau bahkan mencegah timbulnya efek samping tersebut. Salah satu upaya adalah penggunaan zat antioksidan yang terdapat dalam kulit (pericarp) manggis.Tujuan Mengetahui pengaruh pemberian ekstrak kulit manggis (Garcinia mangostana L.) terhadap jumlah kelainan histopatologi dan indeks apoptosis sel rambut koklea pada ototoksisitas gentamisinMetode Penelitian ini menggunakan true experimental with post-test only control group design yang menggunakan tikus wistar sebagai subjek penelitian. Tikus wistar dibagi menjadi tiga kelompok. Kelompok kontrol negatif yang tidak diinduksi apa – apa, kelompok kontrol positif diinduksi gentamisin secara intraperitonial dengan dosis 120 mg/KgBB selama 25 hari dan kelompok perlakuan diinduksi gentamisin secara intraperitonial dengan dosis 120 mg/KgBB selama 25 hari diikuti pemberian ekstrak kulit manggis (Garcinia mangostana L.) secara per oral dengan dosis 100 mg/KgBB pada hari ke -12 sampai dengan hari ke - 25, kemudian diterminasi untuk dinilai jumlah kelainan histopatologi dan indeks apoptosis. Analisis data diolah menggunakan uji Chi-SquareHasil Terdapat perbedaan jumlah kelainan histopatologi yang tidak signifikan antara kelompok yang diberikan gentamisin saja dan kelompok yang diberikan gentamisin dan ekstrak kulit manggis dengan nilai p = 1,000 (p>0,05). Sedangkan apoptosis tidak tampak pada preparat koklea.Kesimpulan Jumlah kelainan histopatologi koklea pada kelompok yang diinduksi gentamisin kemudian diberikan ekstrak kulit manggis lebih rendah dibandingkan dengan kelompok yang hanya diinduksi gentamisin namun tidak signifikan.
Pengaruh Alfa Tokoferol pada Efek Ototoksik Sisplatin Santosa, Yanuar Iman; Samiadi, Dindy; Aroeman, Nur Akbar; Fianza, Pandji Irani
Majalah Kedokteran Bandung Vol 44, No 4 (2012)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (674.033 KB)

Abstract

Kemoterapi sisplatin memiliki efek samping ototoksik, diperantarai radikal bebas, mengakibatkan kematian sel rambut luar koklea, menyebabkan gangguan dengar. Alfa tokoferol memiliki efek otoprotektif terhadap sisplatin pada hewan coba. Diperlukan penelitian lebih lanjut pada manusia. Tujuan penelitian mengukur fungsi pendengaran untuk mengetahui pengaruh pemberian alfa tokoferol per oral pada pencegahan efek ototoksik sisplatin. Dilakukan penelitian uji klinis acak di Rumah Sakit Dr. Hasan Sadikin Bandung (RSHS) periode Desember 2011–Februari 2012 pada dua kelompok. Kelompok perlakuan menjalani pengobatan standar kemoterapi sisplatin dengan tambahan alfa tokoferol per oral dengan dosis 400 International Unit (IU) per hari sejak 1 hari sebelum kemoterapi selama 30 hari. Kelompok kontrol menjalani pengobatan standar kemoterapi sisplatin. Pemeriksaan fungsi pendengaran dilakukan dengan timpanometri, audiometri, dan distortion product otoacoustic emission (DPOAE) sebelum dan setelah kemoterapi siklus pertama dan kedua. Didapatkan hasil kejadian ototoksik setelah siklus pertama lebih rendah secara bermakna pada kelompok 1 (33,3%) dibandingkan dengan kelompok 2 (66,7%) (p=0,046; IK=95%). Demikian juga dengan kejadian ototoksik setelah siklus kedua lebih rendah secara bermakna pada kelompok 1 (50%) dibandingkan dengan kelompok 2 (88,9%) (p=0,027; IK=95%). Simpulan, terapi alfa tokoferol 400 IU per oral dapat mencegah efek ototoksik sisplatin. [MKB. 2012;44(4):205–12].Kata kunci: Alfa tokoferol, ototoksik, sisplatinEffects of Alpha Tocopherol Againts Cisplatin–Induced OtotoxicityOtotoxicity is a known side effect of cisplatin chemotherapy due to formation of free radicals causing death to cochlear outer hair cells, resulting in hearing loss. Alpha tocopherol has otoprotective effects towards cisplatin in animal studies. Further human studies are needed. The objective of this study was to measure hearing function to know the otoprotective effects of alpha tocopherol against cisplatin. A randomized control trial was performed at Dr. Hasan Sadikin Hospital Bandung in December 2011–February 2012 in 2 groups. The treatment group received standard cisplatin chemotherapy treatment and alpha tocopherol 400 International Unit (IU)/day since day 1 before a 30-day-treatment. the control group received standard cisplatin chemotherapy treatment. Hearing evaluation was done using tympanometry, audiometry and distortion product otoacoustic emission (DPOAE) before and after the first and second cycles of chemotherapy. Results showed that ototoxic incidence after the first cycle of chemotherapy was significantly lower in group 1 (33.3%) than group 2 (66.7%) (p=0.046, CI=95%). Ototoxic incidence after the second cycle of chemotherapy was significantly lower in group 1 (50%) than group 2 (88.9%) (p=0.027, CI=95%). In conclusion, oral alpha tocopherol 400 IU can prevent cisplatin-induced ototoxicity. [MKB. 2012;44(4):205–12]Key words: Alpha tocopherol, cisplatin, ototoxicity DOI: http://dx.doi.org/10.15395/mkb.v44n4.176
Effect of Nigella sativa extract on nasal mucosal inflammation in rats exposed to cigarette smoke Alamanda, Fathika; Dewi, Anna Mailasari Kusuma; Marliyawati, Dwi; Santosa, Yanuar Iman
Sains Medika: Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2024): June 2024
Publisher : Faculty of Medicine, Universitas Islam Sultan Agung (UNISSULA), Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30659/sainsmed.v15i1.22833

Abstract

Cigarette smoke contains toxic compounds that can initiate an inflammatory reaction and infiltrate inflammatory cells. The nasal mucosa is the initial part of the respiratory system that comes into contact with irritating chemicals such as cigarettes. Prior studies indicated that Nigella sativa extract (NS) has thymoquinone, a bioactive compound with anti-inflammatory properties. Our study aims to determine the effect of different doses of NS on inflammation of the nasal mucosa in Wistar rats exposed to cigarette smoke. The study employed an experimental post-test-only control group design. Twenty-five Wistar rats were randomly assigned to one of the five groups: negative control (K-), positive control (K+), and three treatment groups of P1, P2, and P3 receiving NS at the dose of 0.5, 1, and 1.5 g/kg bw/day, respectively. All treatment groups and the positive control group were exposed to smoke from 4 cigarettes/day for 28 days. The degree of inflammatory cell infiltration was evaluated using a histological scoring : 0 if normal; 1 if infiltration was less than 1/3; 2 if infiltration was between 1/2 and 2/3, 3 if infiltration of more than 2/3 indicating normal, less than 1/3, 1/3 to 2/3, and more than 2/3, respectively. The degree of inflammatory cell infiltration in group: K(-): 1.00 ±0.00, K(+): 1.00±0.00, P1: 1.00±0.00, P2: 1.00±0.37, and P3: 1.00±0.33. The Kruskal-Wallis test showed a p-value of 0.001, indicating a significant difference. The Mann-Whitney test revealed significant differences between the K+ and P2 groups (p=0.032), K+ and P3 groups (p=0.013), and P1 and P3 groups (p=0.049). In conclusion, NS can decrease the presence of inflammatory cells in the nasal mucosa in Wistar rats exposed to cigarette smoke.
Relationship mastoid pneumatization and eustachian tube shape with tympanic cavity in chronic otitis media Herjanto, Ferry; Naftali, Zulfikar; Santosa, Yanuar Iman; Hendaraningrum, Farah
Oto Rhino Laryngologica Indonesiana Vol. 52 No. 2 (2022): VOLUME 52, NO. 2 JULY - DECEMBER 2022
Publisher : PERHATI-KL

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32637/orli.v52i2.457

Abstract

ABSTRACTBackground: Chronic suppurative otitis media (CSOM) is one of the causes of morbidity and mortality in developing countries. The worldwide prevalence of CSOM according to WHO is estimated at 330 million people. Pneumatic type mastoid pneumatization, narrow Eustachian tube angle, and narrow Eustachian tube diameter in the diseased ear can result in cholesteatoma formation. Objective: This study aimed to determine the relationship between mastoid pneumatization, Eustachian tube angle and diameter with tympanic cavity abnormalities in CSOM patients. Methods: This was a retrospective analysis study using cross sectional method. The data were taken from the patient’s medical records at Dr. Kariadi Hospital, Semarang, from January 2020 to June 2021. Subjects were CSOM sufferers. Mastoid multisliced computed tomography (MSCT) scan examination was carried out in the Radiology Section, using the AW Volume Share 5 application, to assess the type of mastoid pneumatization, Eustachian tube angle, Eustachian tube diameter, and tympanic cavity abnormalities in the form of cholesteatoma, granulation, and erosion of the ossicles. Statistical analysis using Chi Square test, and multivariate test. Result: There were 90 subjects with CSOM, 44 (48.9%) had tympanic cavity abnormalities and 46 (51.1%) without tympanic cavity abnormalities. Sclerotic mastoid pneumatization was more than pneumatic (p=0.001), narrow Eustachian tube angle (p=0.041), and narrow Eustachian tube diameter (p=<0.001). Logistic regression results showed that mastoid pneumatization had a dominant relationship to abnormalities in the tympanic cavity. Conclusion: There was a relationship between sclerotic mastoid pneumatization, narrow Eustachian tube angle, and narrow Eustachian tube diameter with abnormalities in the tympanic cavity. ABSTRAKLatar belakang: Otitis media supuratif kronik (OMSK) merupakan salah satu penyebab morbiditas serta mortalitas di negara berkembang. Prevalensi OMSK menurut WHO di seluruh dunia diperkirakan 330 juta orang. Pneumatisasi mastoid tipe pneumatik, sudut tuba Eustachius yang sempit, dan diameter tuba Eustachius yang lebih sempit pada telinga yang sakit dapat menyebabkan terjadinya kolesteatoma. Tujuan: Penelitian bertujuan untuk mengetahui hubungan pneumatisasi mastoid, sudut dan diameter tuba Eustachius dengan kelainan kavum timpani pada penderita OMSK. Metode: Merupakan penelitian analisis retrospektif menggunakan metode cross sectional. Data diambil dari rekam medis pasien di RSUP Dr.Kariadi Semarang, dari Januari 2020 sampai Juni 2021. Subjek adalah penderita OMSK. Pemeriksaan multisliced computed tomography (MSCT) scan mastoid dilakukan di Bagian Radiologi, dengan aplikasi AW Volume Share 5, untuk menilai jenis pneumatisasi mastoid, sudut tuba Eustachius, diameter tuba Eustachius, dan kelainan kavum timpani berupa kolesteatoma, granulasi, dan erosi pada osikula. Analisis statistik menggunakan uji Chi Square, dan uji multivariat. Hasil: Didapatkan 90 subjek penderita OMSK, adanya kelainan kavum timpani 44 (48,9%) dan yang tidak adanya kelainan kavum timpani 46 (51,1%). Pneumatisasi mastoid sklerotik lebih banyak daripada pneumatik (p=0,001), sudut tuba Eustachius sempit (p=0,041), dan diameter tuba Eustachius pendek (p=<0,001. Hasil regresi logistik menunjukan bahwa pneumatisasi mastoid memiliki hubungan yang dominan terhadap kelainan pada kavum timpani. Kesimpulan: Terdapat hubungan antara pneumatisasi mastoid sklerotik, sudut tuba Eustachius sempit, dan diameter tuba Eustachius kecil dengan kelainan pada kavum timpani.  
Co-Authors Alamanda, Fathika Dewi, Anna Mailasari Kusuma Dindy Samiadi Fathoni, Mohammad Rifqi Hendaraningrum, Farah Herjanto, Ferry Marliyawati, Dwi Nur Akbar Aroeman Pandji Irani Fianza Zulfikar Naftali, Zulfikar