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All Journal Nexus Kedokteran Translasional COMSERVA: Jurnal Penelitian dan Pengabdian Masyarakat Jurnal Locus Penelitian dan Pengabdian
Aulia Agung Sanubari
Faculty of Medicine,SebelasMaret University
Aerospace Engineering Humanities Automotive Engineering Decision Sciences, Operations Research & Management Economics, Econometrics & Finance Education Electrical & Electronics Engineering Industrial & Manufacturing Engineering Mathematics Medicine & Pharmacology Social Sciences

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PerbedaanPengaruh Nefroprotektor Ekstrak Kunyit, Ekstrak Temulawak, dan Kombinasinya Terhadap Kerusakan Histologis Sel Ginjal Mencit yang Diinduksi Parasetamol Sanubari, Aulia Agung; Muthmainah, .; Isdaryanto, .
Nexus Kedokteran Translasional Vol 2, No 1 (2013): Nexus Kedokteran Translasional
Publisher : Fakultas Kedokteran Universitas Sebelas Maret Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (14.207 KB)

Abstract

Background: Turmeric and xanthorrhiza have been known to contain curcumin, and specially xanthorrhiza also contain xanthorrhizol that may exhibit significant protection of kidney cells from free radicals. This study has carried out to evaluate difference nefroprotector effect between turmeric, xanthorrhiza, and combination turmeric and xanthorrhiza on histological damage of kidney cells that induced paracetamol in mice. Methods: Present study was experimental laboratory research with post test only controlled group design.Samples were 30 male Swiss webster mice (2-3 months old) weighing+20 g, and they were divided equally into 5 groups, 6 mice each group. Sampling technique in this research was incidental sampling.KK (-) and KK (+) were given aquadest for 14 days. KP1 was given turmeric extract with the dose of 2,8 mg/20 g body weight of mice, KP2 was given xanthorrhiza extract with the dose of 14 mg/20 g body weight of mice, and KP3 was given combination of turmeric extract with dose 2,8 mg/20 g body weight of mice and xanthorrhiza extract with dose 14 mg/20 g body weight of mice for 14 days.Paracetamol was given to groups ofKK (+), KP1, KP2, and KP3on the 12th, 13th, and 14th day. On day-15th, micewere sacrificedandkidneys weretakento makepreparationsby paraffinblockmethodandHEstaining. Kidney histological features were assessed based on quantifying ofpyknosis, karyorrhexis, and karyolysis. Data were analyzed with the Kruskall-Wallis test (α=0.05) and continued with Mann-Whitney test (α=0.05). Results: Mean KK(-) : 10,33±1,40, KK(+) : 25,88±3,19, KP1 : 15±2,37, KP2 : 11,58±2,33, and KP3 : 13±1,92. Result of statistically data analysis showed that there was a significant difference of kidney damage score between all pairs of groups, except KK(-) - KP2 was not significant. Conclusion: There was a difference nefroprotector effect between turmeric, xanthorrhiza, and combination of them on histological damage of kidney cells that induced paracetamol, and xanthorrhiza extract at dose 14 mg/20 g body weight of mice had a better effect than turmeric extract or combination of them. Keywords: turmeric extract, xanthorrhiza extract, nefroprotector, kidney cells damage.
Hybrid Procedural Management of Multiple Pulmonary Arteriovenous Malformations In A Patient With Hereditary Hemorrhagic Telangiectasia: A Case Report Sanubari, Aulia Agung; Budiono, Enrico A.; Prasetyo, Arif
Jurnal Locus Penelitian dan Pengabdian Vol. 3 No. 10 (2024): Jurnal Locus Penelitian dan Pengabdian
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/locus.v3i10.3216

Abstract

Hereditary Hemorrhagic Telangiectasia (HHT) is an autosomal dominant disorder characterized by vascular malformations, including Pulmonary Arteriovenous Malformations (PAVMs), which can lead to serious complications such as dyspnea and hemorrhage. This report features a 37-year-old woman with HHT and multiple PAVMs. The diagnosis was established through physical examination, laboratory tests, and thoracic multislice computed tomography (MSCT). A hybrid management approach was applied, including embolization and thoracotomy. The patient underwent successful embolization of the inferior segment, followed by thoracotomy to overcome procedural difficulties. After the intervention, the patient's symptoms improved significantly, with no recurrence. Management of complex PAVMs may require a combination of methods, including embolization and surgery. The importance of early detection and adaptive management in HHT patients is expressed, given the high risk of complications. Embolization is the primary treatment for PAVMs, but in complex cases, surgical intervention is required. This study emphasizes the importance of a hybrid management approach and early detection in preventing serious complications in HHT patients, as well as the need for the development of better clinical guidelines for the management of PAVMs.
Acute Traumatic Epidural Hematoma in Geriatri, case report Sanubari, Aulia Agung; Nirbhita, Dety; R, Geizar Arsika
COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat Vol. 4 No. 7 (2024): COMSERVA : Jurnal Penelitian dan Pengabdian Masyarakat
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/comserva.v4i7.2594

Abstract

Acute epidural haematomas (AEDH) are rare cases in geriatric age group as the dura adheres firmly to the inner table of the cranial bone. Trauma Brain Injuries are attributed to several mechanisms of injury, including falls, motor vehicle or other types of road injuries, sports-related injuries, and interpersonal physical violence or violence by other means (e.g., blast injury). Presentation may range widely from normal mental status to severe intracerebral injury in the elderly although acute deterioration may occur in previously conscious patients. There are only a few studies in the literature concerning acute epidural haematomas in geriatric age group. In our case, a 66-year-old male patient with cranial Computerized Tomography (CT) showed AEDH at the right parietotemporooccipital region.
Co-Authors . Isdaryanto . Muthmainah Arif Prasetyo, Arif Budiono, Enrico A. Nirbhita, Dety R, Geizar Arsika