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All Journal Journal of General Procedural Dermatology and Venereology Indonesia Jurnal Kedokteran Meditek
Ratu Siti Khadijah Sarah
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Sifilis Menyerupai Lupus Eritematosus: The Great Imitator Budianti, Windy Keumala; Sarah, Ratu Siti Khadijah
Jurnal Kedokteran Meditek Vol 30 No 1 (2024): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v30i1.2883

Abstract

Manifestasi klinis yang terlihat pada sifilis sering menyerupai penyakit inflamasi kronis seperti lupus eritematosus. Sebuah studi menyatakan angka kejadian misdiagnosis sifilis dengan lupus eritematosus sebanyak 166 kasus sepanjang tahun 2006-2011. Seorang laki-laki 24 tahun datang dengan lesi oral, bercak merah pada kedua telapak tangan dan kaki disertai telogen efluvium, madarosis, artralgia, dan nyeri otot. Pasien telah didiagnosis Lupus Eritematosus Sistemik (LES) dengan keterlibatan mukokutan dan muskuloskeletal berdasarkan klinis dan serologis kemudian dirawat oleh sejawat Internis dengan obat imunosupresan selama 3 minggu tetapi keluhan bertambah parah. Pasien kemudian dirujuk ke dokter dermatologi dan venereologi untuk pengobatan bercak pada telapak tangan dan kaki. Hasil pemeriksaan mengarah pada sifilis sekunder dan didukung hasil serologi. Pasien mendapatkan injeksi benzathine penicillin 2,4 juta IU intramuskular dan klinis membaik dalam satu minggu. Tujuan laporan kasus ini untuk meningkatkan kewaspadaan terhadap diagnosis sifilis yang merupakan the great imitator yang memiliki tampilan klinis dan serologis menyerupai penyakit autoimun.
Herpes Zoster Reactivation Following COVID-19 mRNA Vaccination in an Elderly Patient: A Case Report Sarah, Ratu Siti Khadijah; Hapsari, Yari Castiliani; Yusharyahya, Shannaz Nadia; Miranda, Eliza; Edwar, Sarah Qanita
Journal of General - Procedural Dermatology and Venereology Indonesia Vol. 9, No. 1
Publisher : UI Scholars Hub

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Abstract

Background: Latent varicella-zoster virus (VZV) in nerve ganglia may reactivate into herpes zoster infection. The coronavirus disease (COVID-19) vaccine is suspected of triggering VZV reactivation, although the exact cause is unclear. This case report aims to raise awareness of the potential complications induced by the COVID-19 mRNA vaccine, particularly in elderly patients. Case Illustration: A 62-year-old woman complained of itchy and painful unilateral dermatomal herpetiform blisters six days after mRNA COVID-19 vaccination. The vesicle first appeared on the left breast, spreading to the back. The patient has a history of hypertension. After the administration of 800 mg of acyclovir five times a day for seven days, the vesicles dried up, and no new vesicles emerged. Discussion: The incidence of herpes zoster has been widely reported to occur within 5-7 days after the COVID-19 vaccination, mostly due to the mRNA vaccine. The dysregulated cell-mediated immune system may trigger VZV reactivation. The vaccines have been shown to induce a cellular response with increased CD8+ T-cells and T-helper type 1 CD4+ T cells. The VZV-specific CD8+ cells cannot control VZV after the massive shift of naïve CD8+ T-cells in the setting of COVID-19 vaccination. Hypertension is also allegedly the main comorbid factor for herpes zoster reactivation after COVID-19 vaccination. Conclusion: Increased awareness and early recognition of potential COVID-19 vaccine-related complications, especially in elderly individuals with comorbidities, are important for timely management and prevention of further issues.
Co-Authors Andri Iryawan Edwar, Sarah Qanita Eliza Miranda Hapsari, Yari Castiliani Mardiatmi Susilohati Mardiatmi Susilohati Shannaz Nadia Yusharyahya Windy Keumala Budianti