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All Journal Jurnal Kedokteran Diponegoro Sari Pediatri Paediatrica Indonesiana Berkala Ilmiah Kedokteran Duta Wacana Basic and Applied Nursing Research Journal
Tun Paksi Sareharto
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Journal : Paediatrica Indonesiana

 1 
Vitamin D3 and seizure frequency in children with epilepsy using polypharmacy Aprilyani, Setya Puspa Dewi; Putranti, Alifiani Hikmah; Sareharto, Tun Paksi; Rahmadi, Farid Agung; Pratiwi, Rina
Paediatrica Indonesiana Vol. 65 No. 2 (2025): March 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.2.2025.122-8

Abstract

Background Children with epilepsy usually need vitamin D administration, primarily due to the effects of antiepileptic drugs (AEDs). The use of AEDs, particularly polypharmacy, can reduce serum 25(OH)D levels. Vitamin D improves the function of neurotransmitters furthermore boosting the seizure threshold. There has been relatively little study investigating the effects of vitamin D3 treatment on seizure frequency. Objective To compare seizure frequency before and after administering vitamin D3 to the children with epilepsy who used polypharmacy.  Methods Sixteen children with epilepsy and polypharmacy, aged 2-18 years, from the Pediatric Neurology Clinic, Dr. Kariadi Hospital, Semarang, were studied using a quasi-experimental approach with one group pretest-posttest. The vitamin D3 was given orally for two months with different dosages according to age andsubjects’ pretest serum 25(OH)D levels. Children with vitamin D insufficiency or deficiency were giventherapy dosage, and the normal vitamin D status were given supplementation dosage.Seizure frequency, serum 25(OH)D levels, and vitamin D status were assessed before and after treatment. Results Seizure frequency was significantly lower after vitamin D treatment for the entire group compared to pre- administration (P=0.019). For subjects with hypo-vitamin D levels pre-treatment, median seizure frequency was significantly decreased following normalization of vitamin D levels at one month (P=0.016) and two months (P=0.018) of vitamin D treatment. Using mean data, seizure frequency also significantly decreased at one month and at two months post-treatment. Conclusion Vitamin D3 administration is associated with an increase in serum 25(OH)D levels, as well as a decrease in seizure frequency. Vitamin D3 administration can significantly reduce seizure frequency in epilepsy patients undergoing polypharmacy who are vitamin D deficient.
Analysis of stool SCFA levels in weaning infants, the timing of weaning, and dietary intake Leliana, Vidya; Sareharto, Tun Paksi; Pratiwi, Rina
Paediatrica Indonesiana Vol. 65 No. 4 (2025): July 2025
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi65.4.2025.279-85

Abstract

Background Short-chain fatty acids (SCFA) are metabolites of polysaccharides that cannot be digested by microbiota. Differences in SCFA profiles depend on infant diet and intestinal microbiota. The timing of weaning period from breast milk or formula to solid foods affects the transitional microbiome of the gut. Indonesian Pediatric Society recommend the weaning period at at 6 months old. Objective To analyze for differences in stool SCFA levels in weaning infants according to timing of weaning to introductory solid foods and dietary intake. Methods This cross-sectional study was conducted from February to August 2023 in Semarang Primary Health Care Unit. Subjects were infants aged 4-6 months, who underwent fecal SCFA laboratory analysis consisting of acetate, propionic, butyric, and valeric acids, and total SCFA levels, as well as carbohydrate, protein, lipid, and fiber intake assessment through a 3-day food recall processed with Nutrisurvey software of subjects who transitioned to solids before 6 months vs. at 6 months of age. We compared stool SCFA levels in the two groups using T-test analysis. Results Of 50 infants, 23 children (46%) started weaning from breast milk or formula to food at 6 months of age, and 27 children (54%) started weaning before 6 months of age. In this study, there were no significant differences in SCFA levels between those who started at 6 months and before 6 months (P>0.05). There was a weak positive correlation (r = +0.281) between protein intake and propionic acid level (P=0.0481) in all subjects. Conclusion There is no significant difference in SCFA level between starting the weaning period at 6 months and before. However, there is a positive correlation between protein intake and propionic acid, when the analysis was done on all subjects.
Co-Authors Adhie Nur Radityo Alifiani Hikmah Putranti Anam, Moh Syarofil Aprilyani, Setya Puspa Dewi Dania Emeralda Firdausy Donna Hermawati Farid Agung Rahmadi, Farid Agung Firdausy, Dania Emeralda Galang Skontantinova Hermawan Istiadi Melysa Br. Sitepu Nuh Gusta Ady Yolanda Nurfandini, Fiandra Fadiya Putri Sekar Wiyati Rina Pratiwi Santoso Jaeri Tuntas Dhanardhono Vidya Leliana