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All Journal Jurnal Farmasi Indonesia Open Access Indonesian Journal of Medical Reviews Jurnal Akademika Baiturrahim Jambi
Rakhmi Hidayati
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Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Optimasi HPMC K15M, Karbopol 940, dan Propilen Glikol pada Formula Nanoemulgel Naringenin Metode D-Optimal Mixture Design Rakhmi Hidayati; Opstaria Saptarini; Ilham Kuncahyo
Jurnal Farmasi Indonesia Vol 19 No 2 (2022): Jurnal Farmasi Indonesia
Publisher : Fakultas Farmasi Universitas Setia Budi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31001/jfi.v19i2.1460

Abstract

Naringenin is a flavanone from citrus fruit which has antioxidant activity which has low bioavailability in water. The way to increase the bioavailability of naringenin is to create a SNEDDS delivery system. Nanoemulsion preparations are considered to be comfortless to use due to low viscosity, dispersibility and stability. To solve this problem, SNEDDS is combined into a gel base known as nanoemulgel. The nanoemulgel formed is optimized using D-Optimal Mixture Design method. The aim of this study are determining the combination of HPMC K15M, carbopol 940 and propylene glycol in the optimal nanoemulgel naringenin formula. Naringenin is made into SNEDDS formulation, determined by the hydrogel base formula design: HPMC K15M, carbopol 940, and propylene glycol and obtained 16 formulas. The formed naringenin SNEDDS is dispersed in hydrogel and optimization of viscosity, dispersion, adhesion, cumulative percent of naringenin using franz diffusion cells and stability test are carried out. The data is analyzed on the D-Optimal Mixture Design method using Software Design Expert Version 12. The optimum proportions on a hydrogel base are HPMC K15M of 2%, carbopol 940 of 0.50%, and propylene glycol of 2.50% can have an effect on the critical parameters of viscosity of 3996 cp, dispersion of 5.80 cm, adhesion of 63.39 seconds, and the cumulative percent of naringenin penetration test of 26,54%.
Determinan Pemilihan Penggunaan Metode Kontrasepsi Jangka Panjang (MKJP) di Puskesmas Sungai Jingah M. Bahrul Ilmi; Nurul Indah Qariati; Rakhmi Hidayati
Jurnal Akademika Baiturrahim Jambi Vol. 10 No. 1 (2021): Maret
Publisher : Universitas Baiturrahim

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36565/jab.v10i1.288

Abstract

One of the strategies of the program implementation Plan is listed in its own KB construction of medium-term national (RPJMN) in 2015-2019 is a declining rate of population growth (LPP), decreasing the total birth rate (TFR) per WUS, increasing the use of contraception, decreased needs air-KB which is not met, the declining birth rate in teenagers ages 15-19 years, and decreased unwanted pregnancy of WUS (15-49 years). The scope of use of MKJP (Long-term Contraceptive Methods) is still low and poorly chosen  by  Couples  of  fertile  Age  (PUS)  that  only  amounted  to  9,3%  compared  with  hormonal contraception that is amounted to 88,5%. The purpose of this research is to know the use of determinant Long-term Contraceptive Methods (MKJP) in the Puskesmas Sungai Jingah 2019. This research method using analytic survey with the use of cross sectional. The population is mothers who do visit KB acceptors from January to March 2019 totaled 237 acceptors. The sample in this research is the 70 respondents. Research instrument this is questionnaire with question form and interview. Data analysis with statistical tests test chi square. The desired confidence level is 90% (a = 0,1). Research results showed the use of electoral parity with MKJP (p = 0,488), and support her husband with the use of MKJP (p = 0,003), statistically parity has no relationship with the use of Long-term Contraceptive   Methods (MKJP). While the   husband support   the   selection   of   Long-term use   of Contraceptive Methods (MKJP). Advice for mom user KB is expected to play an active role in the efforts of the use of contraceptives, particularly long -term contraception
Potential for Incompatibility, Instability, and Prescription Drug Interactions in Pulveres Prescription Pediatric Patients at RSI (Islamic Hospital) Sultan Hadlirin, Jepara, Indonesia Setyoningsih, Heni; Gendis Purno Yudanti; Rakhmi Hidayati; Sri Fitriyaningsih
Open Access Indonesian Journal of Medical Reviews Vol. 3 No. 6 (2023): Open Access Indonesian Journal of Medical Reviews
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/oaijmr.v3i6.407

Abstract

In Indonesia, there are still many doctors who prescribe compounded medicines for pediatrics, including pulveres. Compounding is an alternative for pediatrics who cannot swallow tablets, but compounding medicines is a concern because it can cause incompatibility and instability during storage and cause side effects. drug interactions. This study aimed to determine the potential for incompatibility, instability, and drug interactions on pediatric patient prescription sheets. This research is descriptive observational, and data collection is carried outretrospective, data taken from prescription sheets for pediatric patients at RSI Sultan Hadlirin Jepara. The total sample in this study was 247 prescriptions that met the inclusion criteria. The results of the study showed that the age classification of patients 0-5 years who received pulveres prescriptions was 175 (71.8%), while for those aged 6-11 years, it was 72 (29.1%). %). Based on the number of medications, 197 (80.1%) patients received 4-6 medications, while 50 (20.3%) pediatric patients received 2-3 medications. There is no potential for 0% incompatibility. There is the potential for instability in the pediatric prescription sheets. As many as 62 (25.1%) of the active drug substance preparations that experience instability include CTM, paracetamol, and vitamin B complex. There were 126 (51.0%) potential drug interactions based on the pharmacodynamic mechanism of action and 126 (51.0%) based on moderate severity in the salbutamol tablet preparation with pseudoephedrine. It can be concluded that on the prescription sheet, there is no potential for 0% incompatibility, there is a potential for instability of 62 (25.1%), and there is moderate interaction, and pharmacodynamic mechanisms were 126 (51.0%).
Co-Authors Gendis Purno Yudanti Ilham Kuncahyo, Ilham M. Bahrul Ilmi Nurul Indah Qariati Opstaria saptarini Setyoningsih, Heni Sri Fitriyaningsih