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All Journal Smart Medical Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Martha Oktavia Dewi Savitri
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Health Professions Medicine & Pharmacology Public Health

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Combination of stem cell and repetitive transcranial magnetic stimulation in acute ischaemic stroke as a promising treatment: A case report Danuaji, Rivan; Hambarsari, Yetty; Hamidi, Baarid Luqman; Hutabarat, Ervina Arta Jayanti; Tedjo, Raden Andi Ario; Fairuzya, Azmi Farah; Savitri, Martha Oktavia Dewi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art15

Abstract

Stroke is a major contributor to long-term disability and its incidence continues to rise annually. This case report aimed to explore the promising benefits of combining stem cell therapy with repetitive transcranial magnetic stimulation (rTMS) in managing acute ischaemic stroke patients. A 62-year-old male presented with left-sided hemiparesis and hemineglect, as well as a cognitive disturbance in the attention domain. His medical history included uncontrolled hypertension over decades and diabetes mellitus for five years. A non-contrast head computed tomography (CT) scan revealed infarction in the right middle cerebral artery (MCA), with an initial National Institutes of Health Stroke Scale (NIHSS) of 13 upon admission to the Emergency Room. The infection and tumour markers were conducted to confirm no contraindication in this patient receiving stem cell therapy. Following the acute phase, the patient underwent a comprehensive treatment regimen involving both stem cell therapy and serial rTMS. Clinical assessments included NIHSS, Barthel Index, and Fugl-Meyer Assesement to evaluate neurological deficits. Additionally, the Montreal Cognitive Assessment-Indonesian version (MoCA-INA) assessment, electroencephalography examination and motor threshold were conducted. The results of this case report revealed noteworthy improvements in NIHSS, motoric strength, and cognitive function post-treatment. In this case report, improvement in clinical outcomes was obtained in the form of motor strength and higher cortical function. Stem cell therapy combined with rTMS has good potential in treating various neuroregenerative and rehabilitative aspects in ischaemic stroke patients.
Correlation Between Acute Phase Delta NIHSS and Quality of Life Score in Post Thrombotic Infarct Stroke Patient in Dr. Moewardi General Hospital via Tele-Stroke Specific Quality of Life-12 Questionnaire (SSQOL-12) Tedjo, Raden Andi Ario; Savitri, Martha Oktavia Dewi; Putra, Stefanus Erdana
Smart Medical Journal Vol 6, No 3 (2023): December
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v6i3.71300

Abstract

Introduction: Stroke is one of the most common diseases causing disability. Stroke severity assessed using National Institute Health Stroke Scale (NIHSS) was recognized affecting quality of life in stroke patients. This study evaluated the NIHSS delta as a predictor of quality of life in thrombotic stroke patientsMethods: This study was conducted from January to September 2022 with cross-sectional approach. At inpatient setting, NIHSS was assessed at admission, first 24 hours, and discharge. Patient’s quality of life was evaluated using the SSQOL-12 questionnaire via telephone. Bivariate linear regression analysis was used to assess this correlation.Results: Demographic data of 61 patients showed that 65.4% of patients were male, 54.1% of patients aged <60 years, and 67.2% had moderate stroke (NIHSS 6-15). The results of bivariate analysis using linear regression showed that both the 24 hour-delta NIHSS and the delta NIHSS-admission-discharge were positively related to SSQOL-12 score (p = 0.000).Conclusion: Delta NIHSS can be used as clinical improvement predictor with positive correlation to the quality of life in thrombotic stroke patients
Co-Authors Bhisma Murti Fairuzya, Azmi Farah Hambarsari, Yetty Hamidi, Baarid Luqman Hutabarat, Ervina Arta Jayanti Oemar Sri Hartanto Oemar Sri Hartanto Rivan Danuaji Stefanus Erdana Putra Tedjo, Raden Andi Ario