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All Journal Smart Medical Journal JKKI : Jurnal Kedokteran dan Kesehatan Indonesia
Fairuzya, Azmi Farah
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

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Combination of stem cell and repetitive transcranial magnetic stimulation in acute ischaemic stroke as a promising treatment: A case report Danuaji, Rivan; Hambarsari, Yetty; Hamidi, Baarid Luqman; Hutabarat, Ervina Arta Jayanti; Tedjo, Raden Andi Ario; Fairuzya, Azmi Farah; Savitri, Martha Oktavia Dewi
JKKI : Jurnal Kedokteran dan Kesehatan Indonesia JKKI, Vol 15, No 1, (2024)
Publisher : Faculty of Medicine, Universitas Islam Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20885/JKKI.Vol15.Iss1.art15

Abstract

Stroke is a major contributor to long-term disability and its incidence continues to rise annually. This case report aimed to explore the promising benefits of combining stem cell therapy with repetitive transcranial magnetic stimulation (rTMS) in managing acute ischaemic stroke patients. A 62-year-old male presented with left-sided hemiparesis and hemineglect, as well as a cognitive disturbance in the attention domain. His medical history included uncontrolled hypertension over decades and diabetes mellitus for five years. A non-contrast head computed tomography (CT) scan revealed infarction in the right middle cerebral artery (MCA), with an initial National Institutes of Health Stroke Scale (NIHSS) of 13 upon admission to the Emergency Room. The infection and tumour markers were conducted to confirm no contraindication in this patient receiving stem cell therapy. Following the acute phase, the patient underwent a comprehensive treatment regimen involving both stem cell therapy and serial rTMS. Clinical assessments included NIHSS, Barthel Index, and Fugl-Meyer Assesement to evaluate neurological deficits. Additionally, the Montreal Cognitive Assessment-Indonesian version (MoCA-INA) assessment, electroencephalography examination and motor threshold were conducted. The results of this case report revealed noteworthy improvements in NIHSS, motoric strength, and cognitive function post-treatment. In this case report, improvement in clinical outcomes was obtained in the form of motor strength and higher cortical function. Stem cell therapy combined with rTMS has good potential in treating various neuroregenerative and rehabilitative aspects in ischaemic stroke patients.
Comparison of Cognitive Function Examination Using Montreal Cognitive Assessment (MOCA-INA) with Telephone Moca (T-MOCA) Ristinawati, Ira; Fairuzya, Azmi Farah
Smart Medical Journal Vol 5, No 3 (2022): Smart Medical Journal
Publisher : Faculty of Medicine Universitas Sebelas Maret

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13057/smj.v5i3.66435

Abstract

Introduction: The prevalence of dementia tends to increase over time. MOCA assessment tool is a cognitive function screening test that has high sensitivity. Telephone-based MOCA assessment has potential of detection and monitoring dementia which can be widely applied.Methods: This is an observational study with cross-sectional approach in the Neurology Outpatient Department RSUD Dr. Moewardi. The aim of this study is to compare the effectiveness of MOCA-INA assessment tool with the T-MOCA.Results: There were 424 patients who underwent MOCA-INA examination during January-June 2022. After screening, 185 patients were able to complete the study. Subjects consisted of 67 males (36.2%) and 118 females (63.8%); aged 65-74 years (44.9%), 75-84 years (25.9%), and 85 years (29.2%). It was found that the conformity diagnosis of MOCA-INA to T-MOCA was 82.3% in the conversion test. There were significant differences between normal patients and MCI patients in age (p=0.000), education level (p=0.000), MOCA-INA score (p=0.000), and T-MOCA score (p=0.000). The relationship between MOCA-INA and T-MOCA has a strong positive correlation (p = 0.000; r = 0.789). Subsequent correlation test between MOCA-INA and T-MoCA showed a strong significant relationship in the direction of gender (p = 0.000; r = 0.438) and education level (p = 0.000; r = -0.323)Conclusion: Both MOCA-INA and T-MOCA could significantly determine the level of cognitive function with a strong correlation between the two assessments.
Co-Authors Hambarsari, Yetty Hamidi, Baarid Luqman Hutabarat, Ervina Arta Jayanti Ira Ristinawati Martha Oktavia Dewi Savitri Rivan Danuaji Tedjo, Raden Andi Ario