Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Dental Journal (Majalah Kedokteran Gigi)
Vikash Jakhmola
Uttaranchal Institute of Pharmaceutical Sciences, Uttaranchal University, Dehradun, India
Dentistry

Published : 1 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 1 Documents
Search

 1 
Molecular docking study of Zingiber officinale Roscoe compounds as a mumps virus nucleoprotein inhibitor Viol Dhea Kharisma; Santika Lusia Utami; Wahyu Choirur Rizky; Tim Godefridus Antonius Dings; Md Emdad Ullah; Vikash Jakhmola; Alexander Patera Nugraha
Dental Journal Vol. 56 No. 1 (2023): March 2023
Publisher : Faculty of Dental Medicine, Universitas Airlangga https://fkg.unair.ac.id/en

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/j.djmkg.v56.i1.p23-29

Abstract

Background: Mumps virus (MuV) can trigger severe infections, such as parotitis, epididymo-orchitis, and meningitis. The effectiveness of MuV vaccine administration has been proven, but current outbreaks warrant the development of antivirals against MuV. Zingiber officinale var. Roscoe or ginger is often used as an alternative remedy. Currently, there are no known in vitro or in vivo studies that investigate ginger as an MuV antiviral. Purpose: This study aims to evaluate the antiviral potency of the bioactive compounds in Zingiber officinale var. Roscoe against MuV. Methods: Antiviral activity screening was conducted by druglikeness analysis, antiviral probability, molecular docking, and molecular dynamic simulation. Results: As an antiviral, 6-shogaol from Zingiber officinale var. Roscoe has potency against MuV. It has a good binding affinity and can establish interactions with the binding domain of the target protein by forming hydrogen, Van der Waals, and alkyl bonds. Conclusion: The complex of 6-shogaol_NP was predicted to be volatile but stable for triggering inhibitory activity. However, these results must be proved by in vivo and in vitro approaches to strengthen the scientific evidence.
Co-Authors Alexander Patera Nugraha Alyaa Farrah Dibha Arif Nur Muhammad Ansori Arli Aditya Parikesit Maksim Rebezov Maria Kiseleva Md Emdad Ullah Muhammad Hermawan Widyananda Nadezhda Kenijz Rahadian Zainul Santika Lusia Utami Sri Wahyuningsih Svetlana Artyukhova Tim Godefridus Antonius Dings Viol Dhea Kharisma Viol Dhea Kharisma Wahyu Choirur Rizky Yulia Matrosova